3.4.14.2: dipeptidyl-peptidase II

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.14.2

3.4.14.2

glucagon-like

glp-1

mellitus

dpp-iv

incretins

peptidase-4

peptide-1

lysosomal

dipeptides

antidiabetic

glycemic

cathepsins

prolyl

insulinotropic

linagliptin

vildagliptin

metformin

glucose-dependent

glucagon

postprandial

iv-deficient

hypoglycemia

glucose-lowering

exopeptidase

gip

sulfonylurea

aminopeptidases

iv-like

antihyperglycemic

repopulation

3.4.14.5

proline-specific

oligopeptidase

saxagliptin

gelatinase

incretin-based

alogliptin

thiazolidinediones

liraglutide

excursion

gliptins

sodium-glucose

retrorsine

exenatide

post-proline

diprotin

tripeptidyl

crevicular

analysis

medicine

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides =

Synonyms

brain dipeptidyl aminopeptidase A, carboxytripeptidase, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, dipeptidyl peptidase, dipeptidyl peptidase 2, dipeptidyl peptidase II, dipeptidyl-aminopeptidase II, dipeptidylpeptidase II, DP II, DPP, DPP II, DPP-II, DPP2, DPP7, DPPII, DPPV, fibroblast activation protein alpha, GPA, More, peptidase, dipeptidyl, II, QPP, quiescent cell proline dipeptidase, seprase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.2 dipeptidyl-peptidase II

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Results	in table
1	Activating Compound
24	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
1504	Disease/ Diagnostics
3	General Stability
98	IC50 Value
251	Inhibitors
48	Ki Value [mM]
54	KM Value [mM]
19	Localization
38	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
51	Organism
10	PDB ID
38	pH Optimum
10	pH Range
6	pH Stability
5	pI Value
9	Posttranslational Modification
15	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
145	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
166	Substrates and Products (Substrate)
20	Subunits
92	Synonyms
6	Temperature Optimum [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]

Reaction Type

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Reaction Type on EC 3.4.14.2 - dipeptidyl-peptidase II

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hydrolysis of peptide bond

exopeptidase, N-terminus dipeptide