3.4.14.2: dipeptidyl-peptidase II

This is an abbreviated version!
For detailed information about dipeptidyl-peptidase II, go to the full flat file.

Word Map on EC 3.4.14.2

3.4.14.2

glucagon-like

glp-1

mellitus

dpp-iv

incretins

peptidase-4

peptide-1

lysosomal

dipeptides

antidiabetic

glycemic

cathepsins

prolyl

insulinotropic

linagliptin

vildagliptin

metformin

glucose-dependent

glucagon

postprandial

iv-deficient

hypoglycemia

glucose-lowering

exopeptidase

gip

sulfonylurea

aminopeptidases

iv-like

antihyperglycemic

repopulation

3.4.14.5

proline-specific

oligopeptidase

saxagliptin

gelatinase

incretin-based

alogliptin

thiazolidinediones

liraglutide

excursion

gliptins

sodium-glucose

retrorsine

exenatide

post-proline

diprotin

tripeptidyl

crevicular

analysis

medicine

Reaction

release of an N-terminal dipeptide, Xaa-Yaa-/-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides =

Synonyms

brain dipeptidyl aminopeptidase A, carboxytripeptidase, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, dipeptidyl peptidase, dipeptidyl peptidase 2, dipeptidyl peptidase II, dipeptidyl-aminopeptidase II, dipeptidylpeptidase II, DP II, DPP, DPP II, DPP-II, DPP2, DPP7, DPPII, DPPV, fibroblast activation protein alpha, GPA, More, peptidase, dipeptidyl, II, QPP, quiescent cell proline dipeptidase, seprase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.2 dipeptidyl-peptidase II

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	Activating Compound
24	AA Sequence
2	Application
1	CAS Registry Number
2	Cloned(Commentary)
1504	Disease/ Diagnostics
3	General Stability
98	IC50 Value
251	Inhibitors
48	Ki Value [mM]
54	KM Value [mM]
19	Localization
38	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
51	Organism
10	PDB ID
38	pH Optimum
10	pH Range
6	pH Stability
5	pI Value
9	Posttranslational Modification
15	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
145	Source Tissue
11	Specific Activity [micromol/min/mg]
5	Storage Stability
166	Substrates and Products (Substrate)
20	Subunits
92	Synonyms
6	Temperature Optimum [°C]
8	Temperature Stability [°C]
32	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

IC50 Value on EC 3.4.14.2 - dipeptidyl-peptidase II

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to IC50 Value Search

0.0361

(1R,S)-(2E)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile

Homo sapiens

IC50: 0.0361 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0404

(1R,S)-(2E)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile

Homo sapiens

IC50: 0.0404 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0329

(1R,S)-(2Z)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile

Homo sapiens

IC50: 0.0329 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0873

(1R,S)-(2Z)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile

Homo sapiens

IC50: 0.0873 mM, low inhibitory potential against EC 3.4.14.5

669775

0.00013

(3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine

Homo sapiens

679412

0.00000088

(3S)-4-[(3aR,6aR)-hexahydrocyclopenta[b]pyrrol-1(2H)-yl]-4-oxobutane-1,3-diamine

Homo sapiens

678684

0.0000023 - 2.3

(3S)-N1-(4-chlorobenzyl)-4-(2-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine

2 entries

0.62

(3S)-N1-(4-chlorobenzyl)-4-(3-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine

Homo sapiens

IC50: 0.62 nM

669768

0.00000113

(3S)-N1-(4-chlorobenzyl)-4-(3-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine

Homo sapiens

IC50: 1.13 nM

669768

0.00000039

(3S)-N1-(4-chlorobenzyl)-4-(4-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine

Homo sapiens

IC50: 0.39 nM

669768

0.00000055

(3S)-N1-(4-chlorobenzyl)-4-(4-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine

Homo sapiens

IC50: 0.55 nM

669768

0.00000048 - 0.0000011

(3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine

2 entries

0.0000547

1-((2S)-2-amino-4-((4-chlorobenzyl)amino)butanoyl)piperidin-3-ol

Homo sapiens

IC50: 54.7 nM

669768

0.000113

1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidin-4-ol

Homo sapiens

IC50: 113 nM

669768

0.0000065

1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidine-2-carbonitrile

Homo sapiens

IC50: 6.5 nM

669768

0.0255

1-([(4-fluorobenzyl)amino]acetyl)-2-pyrrolidinecarbonitrile

Homo sapiens

IC50: 0.0255 mM

669775

0.00104

1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine

Homo sapiens

IC50: 0.00104 mM, low inhibitory potential against EC 3.4.14.5

669775

0.00104

1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine

Homo sapiens

679412

0.0013

1-benzyl-N-(2-cyclopentylidene-2-fluoroethyl)-4-piperidinamine

Homo sapiens

IC50: 0.0013 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0031

1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine

Homo sapiens

679412

0.0031

1-benzyl-N-[2-oxo-2-(1-piperidinyl)ethyl]-4-piperidinamine

Homo sapiens

IC50: 0.0031 mM, low inhibitory potential against EC 3.4.14.5

669775

0.1335

1-[(1-adamantylamino)acetyl]-2-pyrrolidinecarbonitrile

Homo sapiens

IC50: 0.1335 mM

669775

0.000004

1-[(2S)-2-amino-4-(benzylamino)butanoyl]piperidine-2-carbonitrile

Homo sapiens

IC50: 4.0 nM

669768

0.0000547

1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-3-ol

Homo sapiens

IC50: 54.7 nM

669768

0.000113

1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-4-ol

Homo sapiens

IC50: 113 nM

669768

0.0000065

1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidine-2-carbonitrile

Homo sapiens

IC50: 6.5 nM

669768

0.0000027

3-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)aminomethyl)-benzonitrile

Homo sapiens

IC50: 2.7 nM

669768

0.000085

4-oxo-4-(1-piperidinyl)-N1 -(4-piperidinyl)-1,3-(S)-butanedi-amine

Homo sapiens

IC50: 85 nM

669768

0.0000008

4-oxo-4-(1-piperidinyl)-N1-(2-thienylmethyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.8 nM

669768

0.00000075

4-oxo-4-(1-piperidinyl)-N1-(4-pyridinylmethyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.75 nM

669768

0.017

4-oxo-4-(1-piperidinyl)-N3-(4-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.017 mM

669768

0.0000009

4-oxo-N1-(2-phenylethyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.9 nM

669768

0.00000191

4-oxo-N1-(3-phenylpropyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.91 nM

669768

0.0015

4-oxo-N1-phenyl-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.0015 mM

669768

0.0046

6-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)amino)nicotinonitrile

Homo sapiens

IC50: 0.0046 mM

669768

0.0128

benzyl 4-[(2-cyclohexylidene-2-fluoroethyl)amino]-1-piperidinecarboxylate

Homo sapiens

IC50: 0.0128 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0129

N-(1,3-benzodioxol-5-ylmethyl)-2-cyclohexylidene-2-fluoroethanamine

Homo sapiens

IC50: 0.0129 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0075

N-(1,3-benzodioxol-5-ylmethyl)-2-cyclopentylideneethanamine

Homo sapiens

IC50: 0.0075 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5

669775

0.0913

N-(2-cyclohexylidene-2-fluoroethyl)-1-adamantanamine

Homo sapiens

IC50: 0.0913 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0042

N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine

Homo sapiens

IC50: 0.0042 mM, low inhibitory potential against EC 3.4.14.5

669775

0.011

N-(2-cyclohexylidene-2-fluoroethyl)-N-(2-phenylethyl)-amine

Homo sapiens

IC50: 0.011 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0219

N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-fluorobenzyl)-amine

Homo sapiens

IC50: 0.0219 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0134

N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-methoxybenzyl)amine

Homo sapiens

IC50: 0.0134 mM, low inhibitory potential against EC 3.4.14.5

669775

0.1

N-(2-cyclohexylidene-2-fluoroethyl)aniline

Homo sapiens

IC50: 0.1 mM, low inhibitory potential against EC 3.4.14.5

669775

0.5

N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine

Homo sapiens

IC50: 0.5 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0272

N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-phenylethyl)amine

Homo sapiens

IC50: 0.0272 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0096 - 0.0157

N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine

2 entries

0.0108

N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-fluorobenzyl)amine

Homo sapiens

IC50: 0.0108 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0155

N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-methoxy-benzyl)amine

Homo sapiens

IC50: 0.0155 mM, low inhibitory potential against EC 3.4.14.5

669775

0.09

N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine

Homo sapiens

IC50: 0.09 mM, low inhibitory potential against EC 3.4.14.5

669775

0.062

N-(2-cyclopentylideneethyl)cyclohexanamine

2 entries

0.034

N-benzyl-2-cyclohexylidene-2-fluoroethanamine

Homo sapiens

IC50: 0.034 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0378

N-benzyl-2-cyclopentylidene-2-fluoroethanamine

Homo sapiens

IC50: 0.0378 mM, low inhibitory potential against EC 3.4.14.5

669775

0.026

N-benzyl-2-cyclopentylideneethanamine

2 entries

0.397

N-benzyl-2-oxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.397 mM, low inhibitory potential against EC 3.4.14.5

669775

0.5

N-benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine

Homo sapiens

IC50: 0.5 mM

669775

0.0484

N-benzyl-2-thioxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.0484 mM, low inhibitory potential against EC 3.4.14.5

669775

0.177

N-cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.177 mM, low inhibitory potential against EC 3.4.14.5

669775

0.276

N-cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine

Homo sapiens

IC50: 0.276 mM

669775

0.069

N-cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.069 mM, low inhibitory potential against EC 3.4.14.5

669775

0.092

N-cyclohexyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine

Homo sapiens

IC50: 0.092 mM, low inhibitory potential against EC 3.4.14.5

669775

0.052

N-piperonyl-2-oxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.052 mM, low inhibitory potential against EC 3.4.14.5

669775

0.063

N-piperonyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine

Homo sapiens

IC50: 0.063 mM, low inhibitory potential against EC 3.4.14.5

669775

0.042

N-piperonyl-2-thioxo-2-(1-piperidinyl)ethaneamine

Homo sapiens

IC50: 0.042 mM, low inhibitory potential against EC 3.4.14.5

669775

0.067

N-piperonyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine

Homo sapiens

IC50: 0.067 mM, low inhibitory potential against EC 3.4.14.5

669775

0.0015

N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]acetamide

Homo sapiens

IC50: 0.0015 mM

669768

0.0018

N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]guanidine bis-(trifluoroacetate)

Homo sapiens

IC50: 0.0018 mM

669768

0.0074

N-[3-amino-1-(S)-(1-piperidinylcarbonyl)propyl]guanidine bis-(trifluoroacetate)

Homo sapiens

IC50: 0.0074 mM

669768

0.0074

N-[3-amino-4-oxo-4-(1-piperidinyl)butyl]benzamide

Homo sapiens

IC50: 0.0074 mM

669768

0.0537

N1 -(2-cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine

Homo sapiens

IC50: 0.0537 mM, low inhibitory potential against EC 3.4.14.5

669775

0.00000066

N1 -(4-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.66 nM

669768

0.0000042

N1,N1-di(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 4.2 nM

669768

0.0000006

N1,N1-dibenzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.6 nM

669768

0.00000131

N1-(1-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.31 nM

669768

0.0000027

N1-(2,4-dimethoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 2.7 nM

669768

0.00000023

N1-(2-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.23 nM

669768

0.0546

N1-(2-cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine

Homo sapiens

IC50: 0.0546 mM, low inhibitory potential against EC 3.4.14.5

669775

0.00000185

N1-(2-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.85 nM

669768

0.0000011

N1-(2-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.1 nM

669768

0.00000134

N1-(3-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.34 nM

669768

0.00000177

N1-(3-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.77 nM

669768

0.0235

N1-(3-nitro-2-pyridinyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.0235 mM

669768

0.00000048

N1-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.48 nM

669768

0.00000022

N1-(4-chlorobenzyl)-N1-methyl-4-oxo-4-(1-piperidinyl)-1,3-butanediamine

Homo sapiens

IC50: 0.22 nm

669768

0.0000011

N1-(cyclohexylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 1.1 nM

669768

0.00000203

N1-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 2.03 nM

669768

0.0000186

N1-cyclohexyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 18.6 nM

669768

0.00000039

N1-[2-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.39 nM

669768

0.00000041

N1-[4-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine

Homo sapiens

IC50: 0.41 nM

669768

0.0038

N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide

Homo sapiens

679412

0.0125

N3-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine dihydrobromide

Homo sapiens

IC50: 0.0125 mM

669768

0.00000048

[(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid

Homo sapiens

678684, 679412