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3.4.13.9: Xaa-Pro dipeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidase, go to the full flat file.

Word Map on EC 3.4.13.9

Reaction

hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyamine analogues. No action on Pro-Pro =

Synonyms

clan MG aminopeptidase P-like metallopeptidase, dipeptidase, proline, DPP8, EC 3.4.3.7, gamma-peptidase, imidodipeptidase, LGAS_0712, M24B peptidase, More, MP50, OPAA, OPAA-2, organophosphate acid anhydrolase, organophosphate anhydrolase/prolidase, organophosphorus acid anhydrolase, PepD, PepE, PepI, PepQ, peptidase D, peptidase-Q, PepX, Pf-peptidase, Pfprol, PH0974, PH1149, Ph1prol, Phprol, PLD, post-proline-cleaving aminopeptidase, prolidase, prolidase homolog 1, prolidase homolog 2, prolidase I, prolidase II, Proline dipeptidase, proline iminopeptidase, proline-specific amino dipeptidase, prolyl dipeptidase, PRS, QPP, quiescent cell proline dipeptidase, serum prolidase, X-Pro dipeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro dipeptidase, XPD, XPD43, XPP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.9 Xaa-Pro dipeptidase

Molecular Weight

Molecular Weight on EC 3.4.13.9 - Xaa-Pro dipeptidase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
105000
-
2 * 105000, recombinant His-tagged enzyme, SDS-PAGE
108000 - 116000
115000
-
gel filtration
120000
-
gel filtration
120000 - 130000
-
gel filtration
123000
-
recombinant enzyme from Escherichia coli
132000
-
gradient gel electrophoresis
165000
-
gel filtration, prolidase II
173000
-
gel filtration
185000
-
gel filtration, prolidase II from normal human and mother of patient with prolidase deficiencyr
210000
-
analytical ultracentrifugation
39400
-
2 * 39400, structure-function relationship, overview. The enzyme shows a pita-bread fold that encompasses a highly conserved metal center and substrate-binding pocket that is located in the enzymes C-terminal domain
40000
40164
2 * 40000, recombinant enzyme, SDS-PAGE, 2 * 40164, mass spectrometry
41000
-
gel filtration
42000
42800
calculated from cDNA
43000
-
gel filtration
440000
-
gel filtration
50000
-
2 * 50000, SDS-PAGE
51000
-
2 * 51000, SDS-PAGE
53000
-
x * 58000, processed glycoslyated enzyme, SDS-PAGE, x * 53000, unprocessed enzyme, SDS-PAGE
54305
56000
57000
-
2 * 54305, sequence calculation, 2 * 55000-58000, native enzyme from different tissues, 2 * 56000, recombinant enzyme from Saccharomyces cerevisiae, 2 * 73000, recombinant enzyme from Pichia pastoris, 2 * 58000, recombinant enzyme from CHO cells, 2 * 57000, recombinant enzyme from Escherichia coli
58000
64000
-
1 * 64000 + 1 * 68000, SDS-PAGE
68000
-
1 * 64000 + 1 * 68000, SDS-PAGE
68000 - 70000
-
gel filtration
70000
73000
80000
about, recombinant enzyme, gel filtration
95000
-
2 * 95000, SDS-PAGE, prolidase II from normal human and patients mother
additional information
-
hydrodynamic properties of wild-type and mutant DPP8s