Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.13.9: Xaa-Pro dipeptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidase, go to the full flat file.

Word Map on EC 3.4.13.9

Reaction

hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyamine analogues. No action on Pro-Pro =

Synonyms

clan MG aminopeptidase P-like metallopeptidase, dipeptidase, proline, DPP8, EC 3.4.3.7, gamma-peptidase, imidodipeptidase, LGAS_0712, M24B peptidase, More, MP50, OPAA, OPAA-2, organophosphate acid anhydrolase, organophosphate anhydrolase/prolidase, organophosphorus acid anhydrolase, PepD, PepE, PepI, PepQ, peptidase D, peptidase-Q, PepX, Pf-peptidase, Pfprol, PH0974, PH1149, Ph1prol, Phprol, PLD, post-proline-cleaving aminopeptidase, prolidase, prolidase homolog 1, prolidase homolog 2, prolidase I, prolidase II, Proline dipeptidase, proline iminopeptidase, proline-specific amino dipeptidase, prolyl dipeptidase, PRS, QPP, quiescent cell proline dipeptidase, serum prolidase, X-Pro dipeptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro dipeptidase, XPD, XPD43, XPP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.9 Xaa-Pro dipeptidase

Inhibitors

Inhibitors on EC 3.4.13.9 - Xaa-Pro dipeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S,3R)-3-amino-2-hydroxy-5-methyl-hexanoyl-proline
-
(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl-proline
-
1,10-phenanthroline
1,2-Cylcopentanedicarboxylic acid
-
-
2-mercaptoethanol
acetic acid
-
inhibits the enzyme in colonic tissue, but not in plasma
betulinic acid
-
i.e. 3beta-hdroxy-lup-20(29)-en-28-oic acid, inhibits the enzyme and is involved in anti-angiogenesis due to further inhibition of expression and decrease in expressions of alpha1 and alpha2 integrins, hypoxia-inducible factor 1, HIF-1, and vascular endothelial cell growth factor, detailed overview
captopril
-
inhibits isozyme PD I dose-dependently, but shows no inhibition of isozyme PD II at 0.1 mM
carmustine
-
-
Colchicine
-
colchicine has a slight inhibiting effect on prolidase activity for L-Val-L-Pro, the activity reaches its highest inhibition percentage of 59% at 2.0 mM
Cupferron
-
N-Hydroxy-N-nitrosobenzeneamine ammonium salt
D,L-4-Amino-4-phosphonobutyrate
-
-
D,L-homocysteine
-
inhibits the activity at 50 mM
D,L-homocysteine-thiolactone
-
inhibits the activities of isozymes prolidase I and II in a concentration-dependent manner
daunorubicin
-
a cytotoxic anthracycline, inhibits the enzyme and collagen biosynthesis, inhibition mechanism might act via chelating of essential Mn2+ ions, more effective than doxorubicin, also inhibits DNA synthesis
diisopropylfluorophosphate
-
87% inhibition at 1 mM
Diprotin A
-
-
dithiothreitol
DL-Ethionine
-
activates at concentrations of 1-50 mM, overview
DL-homocysteine
-
slightly activates at concentrations of 1-20 mM, inhibitory at over 30 mM, overview
DL-homocysteine thiolactone
-
activates at concentrations of 1-30 mM, inhibitory at over 50 mM, overview
DL-methionine
-
activates at concentrations of 1-30 mM, inhibitory at over 50 mM, overview
doxorubicin
-
a cytotoxic anthracycline, inhibits the enzyme and collagen biosynthesis, inhibition mechanism might act via chelating of essential Mn2+ ions, less effective than daunorubicin, also inhibits DNA synthesis
doxycyclin
-
induces down-regulation of the enzyme as a post-translational event
echistatin
-
treatment of cells results in inhibition of collagen production and enzyme activity and expression
-
Gly-PSI[CO-CH]-Pro
-
-
His-Pro
substrate inhibition
iodoacetamide
-
-
iodoacetate
L-isoleucine
-
inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
L-Leu-L-Pro
-
-
L-leucine
-
inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
L-proline
-
competitive
L-valine
-
inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
L-valinyl-D-boroproline
-
-
Leu-Pro
substrate inhibition
Lys-Pro
substrate inhibition
melanin
-
30% inhibition at 0.1 mg/ml, reverses inhibition of prolidase by netilmicin
N,N'-diisopropyldiamidofluorophosphate
-
i.e. DDFP or mipafox
N-acetylproline
-
-
N-Benzyloxycarbonyl-L-proline
N-ethylmaleimide
-
-
N-[N'-(2-bromoethyl)-N'-nitrosocarbamoyl]-L-proline
-
-
netilmicin
-
80% inhibition at 0.01 mM, reversible by melanin
NiCl2
p-chloromercuribenzoate
p-hydroxymercuribenzoate
paracetamol
-
mechanism of PLD inhibition by paracetamol is noncompetitive inhibition
Phenacetin
-
-
phenylacetyl-thioproline
-
-
Phenylmethylsulfonylfluoride
-
88.5% inhibition at 1 mM
phosphoenolpyruvate
-
-
Phosphonates
-
-
Phosphonocarboxylates
-
-
-
Pro-Pro
substrate inhibition
sodium salicylate
-
-
trans-1,2-cyclopentanedicarboxylate
-
-
Tyr-Pro
substrate inhibition
Z-Pro
-
roughly 80% inhibition at 2.53 mM
additional information
-