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(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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deregulates the collagen metabolism and strongly induces inhibition of collagen synthesis, but activates the enzyme accompanied by increase in the expression of b1 integrin receptor and some b1 integrin-dependent signalling proteins, e.g. Sos, MAPK ERK1and ERK2, and transcription factor NF-kB, the specific MEK/ERK inhibitor UO126 inhibits campthotecin-induced up-regulation of prolidase activity
8-Br-cGMP
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strong and rapid stimulation of enzyme activity by phosphorylation
alpha-ketoglutarate
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30% activation at 0.01 mM
apigenin-7-O-glucuronide
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stimulates the enzyme and collagen biosynthesis in osteogenesis imperfecta type I cells, overview
Colchicine
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colchicine enhances PLD activity for Gly-L-Pro and L-Leu-L-Pro, the highest enhancement of PLD on Gly-L-Pro is 141% at 0.01 mM
D,L-ethionine
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enhances the activity of isozyme prolidase I, D,L-ethionine strongly enhances the activity of isozyme prolidase II compared with L-ethionine
D-alanine
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activation of isoforms prolidase I and prolidase II
D-ethionine
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enhances the activity of isozymes prolidase I and II
D-isoleucine
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activation of isoforms prolidase I and prolidase II
D-leucine
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activation of isoforms prolidase I and prolidase II
D-serine
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activation of isoforms prolidase I and prolidase II
D-valine
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activation of isoforms prolidase I and prolidase II
diethyldithiocarbamate
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activation
L-alanine
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activation of isoforms prolidase I and prolidase II
L-ethionine
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enhances the activity of isozyme prolidase I
L-isoleucine
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inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
L-leucine
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inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
L-serine
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activation of isoforms prolidase I and prolidase II
L-valine
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inhibitory to enzyme isoform prolidase I, activating isoform prolidase II
MnCl2
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stimulation of activity against substrates L-Pro-Gly, L-Pro-L-Glu, L-Pro-L-Leu, L-Pro-L-Ser, and L-Pro-L-Phe, inhibitory to hydrolysis of substrates L-Pro-L-Ala, L-Pro-L-Val, L-Pro-L-Met, and L-Pro-L-Asp
N-[N'-(2-bromoethyl)-N'-nitrosocarbamoyl]-L-proline
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significantly increases MCF-7 cells prolidase activity, when used at 0.05-0.25 mM concentrations
N-[N'-(2-chloroethyl)-N'-nitrosocarbamoyl]-L-proline
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significantly increases MCF-7 cells prolidase activity, when used at 0.05-0.25 mM concentrations
N-[N'-(3-chloropropyl)-N'-nitrosocarbamoyl]-L-proline
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significantly increases MCF-7 cells prolidase activity, when used at 0.05-0.25 mM concentrations
N-[N'-(4-bromophenyl)-N'-nitrosocarbamoyl]-L-proline
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significantly increases MCF-7 cells prolidase activity, when used at 0.05-0.25 mM concentrations
pectolinarin
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stimulates the enzyme and collagen biosynthesis in osteogenesis imperfecta type I cells, overview
thrombin
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treatment of cells results in enhancement of collagen production and enzyme activity and expression, accompanied by raise in expression of focal adhesion kinase pp125 and mitogen-activated protein kinases
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D,L-homocysteine
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enhances the activity of isozyme prolidase I at low concentration
D,L-homocysteine
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weakly enhances the activity of isozyme prolidase II
D,L-methionine
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slightly enhances the activity of isozyme prolidase I at low concentration
D,L-methionine
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the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by D,L-methionine
D-methionine
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the activity of isozyme prolidase I against Gly-L-Pro is strongly enhanced by D-methionine
D-methionine
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the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by D-methionine
EDTA
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slight activation at 1.0 mM
glycine
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activation of activity against substrates L-Pro-L-Ala, L-Pro-L-Val, L-Pro-L-Met, and L-Pro-L-Asp
glycine
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activation of isoforms prolidase I and prolidase II
L-methionine
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slightly enhances the activity of isozyme prolidase I at low concentration
L-methionine
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the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by L-methionine
NO
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NO stimulate both prolidase activity and collagen biosynthesis in fibroblasts, increase in the enzyme activity is due to increase in the enzyme phosphorylation on serine/threonine residue
NO
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NO-donors such as SIN I and DETA/NO increase enzyme activity in time- and dose-dependent manner. Enzyme activity also increases upon transfection of cells with iNOS. Increased enzymic activity is accompanied by increase in serine/threonine phosphorylation of enzyme
additional information
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phosphorylation at four S109, S134, S198, S236, one T86, and two Y117, Y124 putative sites for phosphorylation, mediated respectively by Mapk pathway and NO/cGMP signaling, upregulate prolidase activity
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additional information
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prolidase activity is dependent on the interaction of collagen with the beta1-integrin receptor subunit
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additional information
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N-acetyl-L-methionine has no effect on activity of isozymes prolidase I and prolidase II
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additional information
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increased enzyme activity in patients with casculogenic erectile dysfunction, highest enzyme activity in patients with arterial insufficiency
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additional information
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no significant effect by 2-mercaptoethanol at 1 mM
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