3.4.13.12: Met-Xaa dipeptidase

This is an abbreviated version!
For detailed information about Met-Xaa dipeptidase, go to the full flat file.

Reaction

Hydrolysis of Met-/-Xaa dipeptides. =

Synonyms

dipeptidase M, methionyl dipeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.13 Dipeptidases

                3.4.13.12 Met-Xaa dipeptidase

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Results	in table
1	CAS Registry Number
2	General Stability
8	Inhibitors
9	KM Value [mM]
6	Metals/Ions
5	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
3	Organism
1	Pathway
3	pH Optimum
2	pH Range
2	Purification (Commentary)
1	Reaction
1	Reaction Type
3	Reference
2	Specific Activity [micromol/min/mg]
1	Storage Stability
36	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.4.13.12 - Met-Xaa dipeptidase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Ala-Ala + H2O

Ala + Ala

Neurospora crassa

-

-

36096

-

36096

ir

Ala-Leu + H2O

Ala + Leu

Neurospora crassa

-

-

36096

-

36096

ir

Ala-Met + H2O

Ala + Met

2 entries

ethionyl-Ala + H2O

ethionine + Ala

Neurospora crassa

-

-

36096

-

36096

ir

Gly-Gly + H2O

Gly + Gly

Escherichia coli

-

-

81205

-

81205

ir

Leu-Ala + H2O

Leu + Ala

2 entries

Met-Ala + H2O

Met + Ala

3 entries

Met-amino acid + H2O

?

2 entries

Met-Glu + H2O

Met + Glu

Escherichia coli

-

cleaved at about 10% of the maximal rate

665080

-

-

?

Met-Gly + H2O

Met + Gly

2 entries

Met-Ile + H2O

Met + Ile

3 entries

Met-Leu + H2O

Met + Leu

3 entries

Met-Met + H2O

Met + Met

Neurospora crassa

-

-

36096

-

36096

ir

Met-Ser + H2O

Met + Ser

3 entries

Met-Thr + H2O

Met + Thr

3 entries

Met-Val + H2O

Met + Val

2 entries

norleucyl-Ala + H2O

norleucine + Ala

Neurospora crassa

-

-

36096

-

36096

ir

Ser-Ala + H2O

Ser + Ala

2 entries

Thr-Ala + H2O

Thr + Ala

2 entries

Ala-Met + H2O

Ala + Met

Escherichia coli

-

-

81205

-

81205

ir

Ala-Met + H2O

Ala + Met

Neurospora crassa

-

-

36096

-

36096

ir

Leu-Ala + H2O

Leu + Ala

Escherichia coli

-

-

81205

-

81205

ir

Leu-Ala + H2O

Leu + Ala

Neurospora crassa

-

-

36096

-

36096

ir

Met-Ala + H2O

Met + Ala

Escherichia coli

-

-

81205

-

81205

ir

Met-Ala + H2O

Met + Ala

Escherichia coli

-

cleaved most rapidly

665080

-

-

?

Met-Ala + H2O

Met + Ala

Neurospora crassa

-

best substrate

36096

-

36096

ir

Met-amino acid + H2O

?

Escherichia coli

-

-

81205

-

-

?

Met-amino acid + H2O

?

Neurospora crassa

-

-

36096

-

-

?

Met-Gly + H2O

Met + Gly

Escherichia coli

-

-

81205

-

81205

ir

Met-Gly + H2O

Met + Gly

Escherichia coli

-

cleaved at about 60% of the maximal rate

665080

-

-

?

Met-Ile + H2O

Met + Ile

Escherichia coli

-

-

81205

-

81205

ir

Met-Ile + H2O

Met + Ile

Escherichia coli

-

cleaved at about 10% of the maximal rate

665080

-

-

?

Met-Ile + H2O

Met + Ile

Neurospora crassa

-

-

36096

-

36096

ir

Met-Leu + H2O

Met + Leu

Escherichia coli

-

-

81205

-

81205

ir

Met-Leu + H2O

Met + Leu

Escherichia coli

-

cleaved at about 60% of the maximal rate

665080

-

-

?

Met-Leu + H2O

Met + Leu

Neurospora crassa

-

-

36096

-

36096

ir

Met-Ser + H2O

Met + Ser

Escherichia coli

-

-

81205

-

81205

ir

Met-Ser + H2O

Met + Ser

Escherichia coli

-

cleaved most rapidly

665080

-

-

?

Met-Ser + H2O

Met + Ser

Neurospora crassa

-

-

36096

-

36096

ir

Met-Thr + H2O

Met + Thr

Escherichia coli

-

-

81205

-

81205

ir

Met-Thr + H2O

Met + Thr

Escherichia coli

-

cleaved at about 60% of the maximal rate

665080

-

-

?

Met-Thr + H2O

Met + Thr

Neurospora crassa

-

-

36096

-

36096

ir

Met-Val + H2O

Met + Val

Escherichia coli

-

-

81205

-

-

?

Met-Val + H2O

Met + Val

Escherichia coli

-

cleaved at about 10% of the maximal rate

665080

-

-

?

Ser-Ala + H2O

Ser + Ala

Escherichia coli

-

-

81205

-

81205

ir

Ser-Ala + H2O

Ser + Ala

Neurospora crassa

-

-

36096

-

36096

ir

Thr-Ala + H2O

Thr + Ala

Escherichia coli

-

-

81205

-

81205

ir

Thr-Ala + H2O

Thr + Ala

Neurospora crassa

-

-

36096

-

36096

ir