3.4.11.9: Xaa-Pro aminopeptidase
This is an abbreviated version!
For detailed information about Xaa-Pro aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.9
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3.4.11.9
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aminopeptidases
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apstatin
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xpnpep2
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lactococci
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medicine
- 3.4.11.9
- aminopeptidases
- apstatin
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xpnpep2
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lactococci
- medicine
Reaction
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide =
Synonyms
aminoacylproline aminopeptidase, aminopeptidase P, aminopeptidase P-like enzyme, aminopeptidase P1, aminopeptidase, aminoacylproline, AMPP, AP-P, APaseP, APP, APP1, APPro, DAP-P, dapUm, Dr-smAPP, Ec-smAPP, ecAPP, hAPP1, hcAMPP, Icp55, LeAPP1, LeAPP2, M24B peptidase, mAmP, Membrane-bound AmP, Membrane-bound APP, membrane-bound proline-specific APaseP, More, Mt-smAPP, Pa-PepP, PEPP, PepQ, peptidase PepQ, PepX aminopeptidase, PfAPP, proline aminopeptidase, sll0136, small aminopeptidase-P, TgAPP, TvMP50, X-Pro aminopeptidase, X-prolyl aminopeptidase, X-prolyl aminopeptidase 2, X-prolyl aminopeptidase 3, X-prolyl peptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro aminopeptidase, Xaa-Pro aminopeptidase-1, Xaa-Pro aminopeptidase-2, Xaa-Pro dipeptidase, XPD, XpmA, XPNEP2, XPNPEP-1, XPNPEP-2, XPNPEP1, XPNPEP2, XPNPEP3, YpdF
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3.4.11.9 Xaa-Pro aminopeptidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.11.9 - Xaa-Pro aminopeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
bradykinin + H2O
?
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potential natural substrate, efficiently hydrolyzed by PfAPP
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-
?
FPHFD + H2O
?
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globin pentapeptide sequence, potential natural substrate, efficiently hydrolyzed by PfAPP
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?
N6-(2-aminobenzoyl)-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
N6-(2-aminobenzoyl)-L-Lys + Pro-Pro-4-nitroanilide
YPWTQ + H2O
?
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globin pentapeptide sequence, potential natural substrate, efficiently hydrolyzed by PfAPP
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-
?
bradykinin + H2O
Arg + des-Arg-bradykinin
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enzyme activity in plasma of humans with previous angio-oedema, a rare but potentially life-threatening side-effect of angiotensin-converting enzyme inhibitor treatment, is low compared to humans without this sensitivity and might be a predisposing factor for development of angio-oedema
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?
bradykinin + H2O
Arg + des-Arg-bradykinin
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the enzyme contributes to the degradation of bradykinin in human skin, especially in case of angiotensin-converting enzyme inhibition
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?
N6-(2-aminobenzoyl)-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
N6-(2-aminobenzoyl)-L-Lys + Pro-Pro-4-nitroanilide
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APP cleaves the Lys-Pro peptide bond separating the fluorogenic aminobenzoyl residue and the internal quenching residue 4-nitroanilide
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-
?
N6-(2-aminobenzoyl)-L-Lys-L-Pro-L-Pro-4-nitroanilide + H2O
N6-(2-aminobenzoyl)-L-Lys + Pro-Pro-4-nitroanilide
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APP cleaves the Lys-Pro peptide bond separating the fluorogenic aminobenzoyl residue and the internal quenching residue 4-nitroanilide
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?
additional information
?
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enzyme may be important for the modulation of the biological activity of neuropeptides
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?
additional information
?
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the enzyme is involved in the pulmonary inactivation of circulating bradykinin
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?
additional information
?
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the enzyme may have an important role in the pulmonary degradation of the potent vasoactive peptide, bradykinin
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?
additional information
?
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aminopeptidase P appears to be an important enzyme for debittering of casein-derived peptides
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-
?
additional information
?
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specific role in the catabolism of proline-containing peptides in both the vacuole and the cytosol, enzyme is required for efficient parasite proliferation
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?
additional information
?
-
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the enzyme accounts for virtually all of the pulmonary inactivation of bradykinin injected in vitro
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?
additional information
?
-
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the enzyme probably plays an important role in conjunction with other intestinal prolyl peptidases in the digestion of proline containing peptides and proteins
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?
additional information
?
-
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the enzyme plays an important role in hydrolysis of Xaa-Pro-Yaa peptides
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?
additional information
?
-
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the enzyme participates in the myocardial kinin metabolism to the same extent as angiotensin-converting enzyme, APP inhibition leads to a reduction in myocardial infarct size by the bradykinin-dependent pathway, synergistic with inhibition of angiotensin-converting enzyme, overview
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?
additional information
?
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the enzyme is involved in degradation of peptide intermediates
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?
additional information
?
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X-prolyl aminopeptidase (APP) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of N-terminal amino acid present adjacent to a penultimate proline residue
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?
additional information
?
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X-prolyl aminopeptidase (APP) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of N-terminal amino acid present adjacent to a penultimate proline residue
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?
