3.4.11.9: Xaa-Pro aminopeptidase
This is an abbreviated version!
For detailed information about Xaa-Pro aminopeptidase, go to the full flat file.
Reaction
release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
=
Synonyms
aminoacylproline aminopeptidase, aminopeptidase P, aminopeptidase P-like enzyme, aminopeptidase P1, aminopeptidase, aminoacylproline, AMPP, AP-P, APaseP, APP, APP1, APPro, DAP-P, dapUm, Dr-smAPP, Ec-smAPP, ecAPP, hAPP1, hcAMPP, Icp55, LeAPP1, LeAPP2, M24B peptidase, mAmP, Membrane-bound AmP, Membrane-bound APP, membrane-bound proline-specific APaseP, More, Mt-smAPP, Pa-PepP, PEPP, PepQ, peptidase PepQ, PepX aminopeptidase, PfAPP, proline aminopeptidase, sll0136, small aminopeptidase-P, TgAPP, TvMP50, X-Pro aminopeptidase, X-prolyl aminopeptidase, X-prolyl aminopeptidase 2, X-prolyl aminopeptidase 3, X-prolyl peptidase, X-prolyl-dipeptidyl aminopeptidase, Xaa-Pro aminopeptidase, Xaa-Pro aminopeptidase-1, Xaa-Pro aminopeptidase-2, Xaa-Pro dipeptidase, XPD, XpmA, XPNEP2, XPNPEP-1, XPNPEP-2, XPNPEP1, XPNPEP2, XPNPEP3, YpdF
ECTree
KCat KM Value
KCat KM Value on EC 3.4.11.9 - Xaa-Pro aminopeptidase
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1.94
Tyr-Ala-Ala
pH 7.5, 40°C
7.78
Tyr-Pro-Ala
pH 7.5, 40°C
4.8
Arg-Pro-Ala
pH 8.0, 55°C, recombinant mutant D53A
18
Arg-Pro-Ala
pH 8.0, 55°C, recombinant mutant Y56A
29
Arg-Pro-Ala
pH 8.0, 55°C, recombinant mutant R55A
114
Arg-Pro-Ala
pH 8.0, 55°C, recombinant wild-type
2.57
bradykinin
pH 7.5, 37°C, recombinant mutant R535A
6.12
bradykinin
pH 7.5, 37°C, recombinant mutant R535A, with 0.1 mM guanidine hydrochloride
9
bradykinin
pH 7.5, 37°C, recombinant mutant Y527F
22.22
bradykinin
pH 7.5, 37°C, recombinant mutant R535A, with 1.0 mM guanidine hydrochloride
50.92
bradykinin
pH 7.5, 37°C, recombinant mutant R535A, with 10 mM guanidine hydrochloride
64.71
bradykinin
pH 7.5, 37°C, recombinant wild-type enzyme
6.5
Met-Ala-Ala
pH 8.0, 55°C, recombinant wild-type
11
Met-Ala-Ala
pH 8.0, 55°C, recombinant wild-type
70
Met-Ala-Ala
pH 8.0, 55°C, recombinant wild-type
2.85
Met-Pro
pH 8.0, 55°C, recombinant wild-type
4.17
Met-Pro
pH 8.0, 55°C, recombinant wild-type
8.15
Met-Pro
pH 8.0, 55°C, recombinant wild-type
8.8
Met-Pro-Ala
pH 8.0, 55°C, recombinant mutant D53A
9.3
Met-Pro-Ala
pH 8.0, 55°C, recombinant wild-type
12.8
Met-Pro-Ala
pH 7.5, 40°C
14
Met-Pro-Ala
pH 8.0, 55°C, recombinant wild-type
24
Met-Pro-Ala
pH 8.0, 55°C, recombinant mutant R55A
36
Met-Pro-Ala
pH 8.0, 55°C, recombinant mutant Y56A
127
Met-Pro-Ala
pH 8.0, 55°C, recombinant wild-type