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3.4.11.7: glutamyl aminopeptidase

This is an abbreviated version!
For detailed information about glutamyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.7

Reaction

release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide =

Synonyms

acid aminopeptidase, acidic alpha-aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A ectopeptidase, aminopeptidase, aspartate, aminopeptidase-A, angiotensinase, angiotensinase A, antigen BP-1/6C3 of mouse B lymphocytes, AP A, APA, Asp-AP, aspartate aminopeptidase, aspartyl aminopeptidase, aspartyl-aminopeptidase, BP-1, BP-1/6C3 antigen, BP1/6C3, Ca2+-activated glutamate aminopeptidase, Differentiation antigen gp160, EAP, ENPEP, GAP, GluAP, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, glutamyl aminopeptidase (Lactococcus), glutamyl peptidase, glutamyl-aminopeptidase, glutamyl-AP, hAPA, L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, L-aspartate aminopeptidase, LAP-A, Lb-PepA, Lc-PepA, leucine aminopeptidase A, M18 aspartyl aminopeptidase, mAPA, membrane aminopeptidase II, membrane-bound aspartyl-AP, MHJ_0125, More, N-terminal acidic amino acid-specific aminopeptidase, PepA, tricorn interacting factor F3, tricorn protease-interacting factor F3, type II Zn2+ membrane-bound aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.7 glutamyl aminopeptidase

Specific Activity

Specific Activity on EC 3.4.11.7 - glutamyl aminopeptidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000003
-
substrate Glu-4-methyl-coumaryl-7-amide
0.000004
0.0000071
0.0000138
-
substrate Glu-4-methyl-coumaryl-7-amide
0.000014
0.000028
-
plasma enzyme, 37°C
0.000045
-
membrane-bound glutamyl aminopeptidase activity in the atrium of hypothyroid adult male rats
0.000046
-
plasma enzyme, 37°C
0.00005
-
membrane-bound glutamyl aminopeptidase activity in the atrium of euthyroid adult male rats
0.00006
-
plasma enzyme, 20°C
0.000065
-
membrane-bound glutamyl aminopeptidase activity in the atrium of hyperthyroid adult male rats
0.000069
-
plasma enzyme, 20°C
0.00007
-
plasma enzyme, 37°C
0.000686
-
DOCA-salt rat, 30 mg/kg RB150, 3.5 h after po
0.00071
-
DOCA-salt rat, 50 mg/kg RB150, 3.5 h after po
0.000726
-
DOCA-salt rat, 15 mg/kg RB150, 3.5 h after po
0.000728
-
normotensive WKY rat, 15 mg/kg RB150, 3.5 h after po
0.000752
-
normotensive WKY rat, 3.5 h after administration of saline po
0.00077
-
normotensive Sham rat, 3.5 h after administration of saline po
0.001083
-
DOCA-salt rat, 7.5 mg/kg RB150, 3.5 h after po
0.001525
-
DOCA-salt rat, 3.5 h after administration of saline po
0.001557
-
DOCA-salt rat, 15 mg/kg RB150, 24 h after po
0.09
-
aminopeptidase A activity, tegmentum/colliculi, aminopeptidase A-deficient mice
0.25
mutant enzyme T348Y, in the absence of Ca2+
0.4
-
aminopeptidase A activity, striatum, wild-type mice
0.45
-
aminopeptidase A activity, cortex, wild-type mice
0.6
substrate: L-Arg-7-amido-4-methylcoumarin, pH 8.0, 60°C
0.629
-
-
0.7
substrate: L-Tyr-7-amido-4-methylcoumarin, pH 8.0, 60°C
0.85
recombinant reactivated CuCu-PepA, pH 7.0, 55°C, substrate L-aspartate-beta-naphthylamide
1
substrate: L-Val-7-amido-4-methylcoumarin, pH 8.0, 60°C
1.1
substrate: Gly-7-amido-4-methylcoumarin, pH 8.0, 60°C
1.3
recombinant reactivated NiNi-PepA, pH 6.0, 60°C, substrate L-aspartate-beta-naphthylamide
1.4
-
aminopeptidase A activity, tegmentum/colliculi, wild-type mice
1.6
mutant enzyme T348D, in the presence of 4 mM Ca2+
1.98
wild type enzyme, in the absence of Ca2+
11
-
aminopeptidase A activity depending on alcohol, lung, wild-type mice, without access to a 10% ethanol solution
12
-
ATA I
132
-
substrate Asp-4-nitroanilide, pH 7.2, 37°C
14.67
wild type enzyme, in the presence of 4 mM Ca2+
15
substrate: L-Ala-7-amido-4-methylcoumarin, pH 8.0, 60°C
19.76
-
-
2.42
purified recombinant untagged enzyme, pH 6.0, 60°C, substrate L-Asp-4-nitroanilide
21
-
aminopeptidase A activity depending on alcohol, kidney, wild-type mice, without access to a 10% ethanol solution
22.8
-
-
26
-
aminopeptidase A activity depending on alcohol, kidney, wild-type mice, with access to a 10% ethanol solution
27.2
recombinant reactivated ZnZn-PepA, pH 6.0, 60°C, substrate L-aspartate-beta-naphthylamide
3
substrate: L-Pro-7-amido-4-methylcoumarin, pH 8.0, 60°C
3.05
mutant enzyme T348S, in the absence of Ca2+
31.54
mutant enzyme T348S, in the presence of 4 mM Ca2+
319
-
substrate Glu-4-nitroanilide, pH 7.2, 37°C
34.7
substrate: L-Leu-7-amido-4-methylcoumarin, pH 8.0, 60°C
36.1
-
-
40
-
ATA II
53.3
recombinant reactivated CoCo-PepA, pH 6.0, 65°C, substrate L-aspartate-beta-naphthylamide
54.9
-
-
607
Glu-7-amido-4-methylcoumarin
66.3
-
substrate Glu-Glu, pH 7.2, 37°C
662.5
Asp-7-amido-4-methylcoumarin
7
-
aminopeptidase A activity depending on alcohol, lung, wild-type mice, with access to a 10% ethanol solution
7.4
mutant enzyme T348Y, in the presence of 4 mM Ca2+
72.4
substrate: L-Glu-7-amido-4-methylcoumarin, pH 8.0, 60°C
78.6
recombinant reactivated MnMn-PepA, pH 6.0, 60°C, substrate L-aspartate-beta-naphthylamide
9.88
-
1 mM Glu-p-nitranilide in 0.05 M Tris/HCl, pH 7.5
additional information