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3.4.11.7: glutamyl aminopeptidase

This is an abbreviated version!
For detailed information about glutamyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.7

Reaction

release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide =

Synonyms

acid aminopeptidase, acidic alpha-aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A ectopeptidase, aminopeptidase, aspartate, aminopeptidase-A, angiotensinase, angiotensinase A, antigen BP-1/6C3 of mouse B lymphocytes, AP A, APA, Asp-AP, aspartate aminopeptidase, aspartyl aminopeptidase, aspartyl-aminopeptidase, BP-1, BP-1/6C3 antigen, BP1/6C3, Ca2+-activated glutamate aminopeptidase, Differentiation antigen gp160, EAP, ENPEP, GAP, GluAP, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, glutamyl aminopeptidase (Lactococcus), glutamyl peptidase, glutamyl-aminopeptidase, glutamyl-AP, hAPA, L-alpha-aspartyl(L-alpha-glutamyl)-peptide hydrolase, L-aspartate aminopeptidase, LAP-A, Lb-PepA, Lc-PepA, leucine aminopeptidase A, M18 aspartyl aminopeptidase, mAPA, membrane aminopeptidase II, membrane-bound aspartyl-AP, MHJ_0125, More, N-terminal acidic amino acid-specific aminopeptidase, PepA, tricorn interacting factor F3, tricorn protease-interacting factor F3, type II Zn2+ membrane-bound aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.7 glutamyl aminopeptidase

KI Value

KI Value on EC 3.4.11.7 - glutamyl aminopeptidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0044
(1-aminopropane-1,3-diyl)bis(phosphonic acid)
-
0.00034
(3R)-3-amino-3-phosphonopropanoic acid
-
0.000314 - 0.01
(4R)-4-amino-5-sulfanylpentanoic acid
0.000268 - 0.002
(S)-3-amino-4-mercapto-butyl sulfonic acid
0.00025
(S)-3-amino-4-mercaptobutyl sulfonic acid
-
-
0.000118 - 0.0139
2,6-diaminohexane-1-thiol
2
3-amino-3-[hydroxy(phenyl)phosphoryl]propanoic acid
-
0.0427
3-[(1-amino-2-carboxyethyl)(hydroxy)phosphoryl]-2-methylpropanoic acid
-
0.1831
3-[[amino(carboxy)methyl](hydroxy)phosphoryl]-2-methylpropanoic acid
-
0.000074 - 0.0065
4-amino-4-phosphonobutyric acid
0.105
5-amino-5-phosphonopentanoic acid
-
0.0000009
Ala-PSI[PO2-CH2]-Leu-Ala
pH 7.4, 25°C
0.0000059 - 0.0001927
amastatin
0.0271
amino(phosphono)acetic acid
-
0.395
amino[hydroxy(methyl)phosphoryl]acetic acid
-
0.00026 - 0.001297
angiotensin IV
0.0141 - 0.0289
captopril
0.0019 - 0.016
D-glutamate phosphonic acid
0.00025
EC33
-
-
0.000194
Glu-PSI[PO2-CH2]-Leu
pH 7.4, 25°C
0.0000008
Glu-PSI[PO2-CH2]-Leu-Ala
pH 7.4, 25°C
0.00003
Glu-PSI[PO2-CH2]-Leu-Arg
pH 7.4, 25°C
0.0000057
Glu-PSI[PO2-CH2]-Leu-Asp
pH 7.4, 25°C
0.000037
Glu-PSI[PO2-CH2]-Leu-Leu
pH 7.4, 25°C
0.000038 - 0.056
glutamate phosphonic acid
0.00038 - 0.00206
glutamate thiol
0.00012 - 0.01
glutamate-thiol
0.000462 - 0.00202
glutamine-thiol
0.000045 - 0.021
L-glutamate phosphonic acid
0.0001 - 0.00394
lysine thiol
0.00046 - 0.0199
lysine-thiol
0.00019 - 0.0084
methionine thiol
0.000475 - 0.00918
methionine-thiol
0.00007
N-(2-aminoethyl)-4-methyl-5-sulfanyl-pentanamide
wild type enzyme, in 50 mM Tris/HCl buffer (pH 7.4), 4 mM Ca2+, at 37°C
0.00025
[(S)-3-amino-4-mercaptobutyl sulfonic acid]
-
-
0.000292
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-D-Ile-Asp-OH
pH 7.3, 37°C
0.0000833
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-3-sulfoalanine-OH
pH 7.3, 37°C
0.000053 - 0.00047
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-Asp-OH
0.000283
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-D-Asp-OH
pH 7.3, 37°C
0.0042
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-NH2
pH 7.3, 37°C
0.0012
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-OH
pH 7.3, 37°C
0.000027
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Tyr-Asp-OH
pH 7.3, 37°C
0.0000733
[[(2R,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Tyr-homosulfoalanine-OH
pH 7.3, 37°C
0.000267
[[(2R,3R)-3-amino-5-carboxylate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.00091
[[(2R,3R)-3-amino-5-phosphonate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.00005
[[(2R,3S)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.000016
[[(2R,3S)-3-amino-5-carboxylate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.000051
[[(2RS,3RS)-3-amino2-sulfhydryl-5-sulfamoyl]pentane]-Ile-Asp-OH
pH 7.3, 37°C
0.00008
[[(2RS,3RS)-3-amino2-sulfhydryl-5-sulfamoyl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.00015
[[(2RS,3RS)-3-amino2-sulfhydryl-5-sulfamoyl]pentanoyl]-Tyr-Asp-OH
pH 7.3, 37°C
0.0000147
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-D-Ile-Asp-OH
pH 7.3, 37°C
0.0000036
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-3-sulfoalanine-OH
pH 7.3, 37°C
0.0000032 - 0.000015
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-Asp-OH
0.00000536
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-D-Asp-OH
pH 7.3, 37°C
0.000145
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-NH2
pH 7.3, 37°C
0.00004
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-OH
pH 7.3, 37°C
0.0000043
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Tyr-Asp-OH
pH 7.3, 37°C
0.0000093
[[(2S,3R)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Tyr-homosulfoalanine-OH
pH 7.3, 37°C
0.00000356
[[(2S,3R)-3-amino-5-carboxylate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.000012
[[(2S,3R)-3-amino-5-phosphonate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.00002
[[(2S,3S)-3-amino-2-sulfhydryl-5-sulfonate]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
0.000013
[[(2S,3S)-3-amino-5-carboxylate-2-sulfhydryl]pentanoyl]-Ile-Asp-OH
pH 7.3, 37°C
additional information
additional information
-
inhibition constant of 3-amino-4-thio-butyl sulfonic acid for aminopeptidase A: 0.29 microM/L
-