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3.4.11.6: aminopeptidase B

This is an abbreviated version!
For detailed information about aminopeptidase B, go to the full flat file.

Word Map on EC 3.4.11.6

Reaction

release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys =

Synonyms

AAP, ACE2, Aminopeptidase, aminopeptidase B, aminopeptidase, arginine, aminopeptidase-B, Ap-B, APB, Arg-AP, Arg/Lys aminopeptidase, ArgAP, arginine aminopeptidase, arginine-aminopeptidase, arginyl aminopeptidase, arginyl peptidase, arylamidase, arylamidase II, BSAP, chloride-dependent-basic aminopeptidase, Cl--activated arginine aminopeptidase, Cl--activated arinine aminopeptidase, Co(II)-Ap-B, ColAP, cold-active aminopeptidase, Cu(II)-Ap-B, cytosol aminopeptidase, cytosol aminopeptidase IV, DAP BII, dipeptidyl aminopeptidase BII, double-zinc aminopeptidase, EC 3.4.13.6, KAP, L-arginine aminopeptidase, L-RAP, LAPase, leukocyte-derived arginine aminopeptidase, LRAP, lysine-specific aminopeptidase, minopeptidase, More, protease IV, pumAPE, RAP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.6 aminopeptidase B

Turnover Number

Turnover Number on EC 3.4.11.6 - aminopeptidase B

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.06 - 9.27
Arg 4-methylcoumarin 7-amide
2.3
Arg-4-methylcoumaryl-7-amide
pH 7.5, 37°C
53.1 - 69.5
Arg-beta-naphthylamide
1.07 - 3.63
Arg-Met-enkephalin
10700
Cys-Gly
-
pH 7.5, 37°C
1.99 - 2.35
kallidin
0.37
L-Ala-4-nitroanilide
pH 8.0, 30°C
0.043 - 0.36
L-Ala-Ala-Pro-Leu-4-nitroanilide
0.49 - 69.47
L-Arg-2-naphthylamide
34
L-Arg-4-nitroanilide
pH 8.0, 30°C
2.95 - 43
L-Arg-7-amido-4-methylcoumarin
55
L-Leu-4-nitroanilide
pH 8.0, 30°C
0.037 - 79.3
L-Lys-2-naphthylamide
10
L-Lys-4-nitroanilide
pH 8.0, 30°C
1.56 - 12.9
L-Lys-7-amido-4-methylcoumarin
1 - 2.1
L-Tyr-2-naphthylamide
0.43
L-Val-4-nitroanilide
pH 8.0, 30°C
307
Leu-4-nitroanilide
-
pH 7.5, 37°C
6630
Leu-Gly
-
pH 7.5, 37°C
1.95 - 14.9
Lys 4-methylcoumarin 7-amide
0.47 - 0.48
Met-enkephalin