3.4.11.6: aminopeptidase B

This is an abbreviated version!
For detailed information about aminopeptidase B, go to the full flat file.

Word Map on EC 3.4.11.6

Reaction

release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys =

Synonyms

More, Aminopeptidase, aminopeptidase, arginine, L-arginine aminopeptidase, arginyl aminopeptidase, arylamidase II, arginine aminopeptidase, Cl--activated arginine aminopeptidase, cytosol aminopeptidase, KAP, AAP, RAP, L-RAP, leukocyte-derived arginine aminopeptidase, protease IV, ACE2, double-zinc aminopeptidase, BSAP, LAPase, ColAP, cold-active aminopeptidase, Ap-B, pumAPE, arginine-aminopeptidase, Arg-AP, chloride-dependent-basic aminopeptidase, APB, arylamidase, cytosol aminopeptidase IV, Cl--activated arinine aminopeptidase, arginyl peptidase, ArgAP, LRAP, aminopeptidase-B, Co(II)-Ap-B, Cu(II)-Ap-B, Arg/Lys aminopeptidase, lysine-specific aminopeptidase, aminopeptidase B, dipeptidyl aminopeptidase BII, DAP BII, minopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.6 aminopeptidase B

Subunits

Subunits on EC 3.4.11.6 - aminopeptidase B

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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 58000, SDS-PAGE
monomer
oligomer
-
x * 86000, SDS-PAGE
polymer
-
? * 83000, SDS-PAGE
tetramer
-
4 * 25500, SDS-PAGE after treatment with mercaptoethanol
trimer
-
3 * 60000, SDS-PAGE
additional information
LTA4H folds into three domains and creates a deep cleft harboring the catalytic Zn2+ site, forming the active site with an L-shaped hydrophobic pocket deep into the protein