3.4.11.6: aminopeptidase B

This is an abbreviated version!
For detailed information about aminopeptidase B, go to the full flat file.

Word Map on EC 3.4.11.6

Reaction

release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys =

Synonyms

More, Aminopeptidase, aminopeptidase, arginine, L-arginine aminopeptidase, arginyl aminopeptidase, arylamidase II, arginine aminopeptidase, Cl--activated arginine aminopeptidase, cytosol aminopeptidase, KAP, AAP, RAP, L-RAP, leukocyte-derived arginine aminopeptidase, protease IV, ACE2, double-zinc aminopeptidase, BSAP, LAPase, ColAP, cold-active aminopeptidase, Ap-B, pumAPE, arginine-aminopeptidase, Arg-AP, chloride-dependent-basic aminopeptidase, APB, arylamidase, cytosol aminopeptidase IV, Cl--activated arinine aminopeptidase, arginyl peptidase, ArgAP, LRAP, aminopeptidase-B, Co(II)-Ap-B, Cu(II)-Ap-B, Arg/Lys aminopeptidase, lysine-specific aminopeptidase, aminopeptidase B, dipeptidyl aminopeptidase BII, DAP BII, minopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.6 aminopeptidase B

General Information

General Information on EC 3.4.11.6 - aminopeptidase B

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
LTB4 levels are persistently elevated in bronchoalveolar lavage fluid (BALF) of lipopolysaccharide (LPS)-induced ALI, and the leukotriene levels in pulmonary edema fluid are significantly higher in ALI patients compared to control patients with hydrostatic pulmonary edema. In addition, LTB4 level is increased in lung homogenates, and BALF of patients with IPF and the level of LTB4 correlate with the extent of fibrosis in histological sections
additional information
LTA4H folds into three domains and creates a deep cleft harboring the catalytic Zn2+ site, forming the active site with an L-shaped hydrophobic pocket deep into the protein