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3.4.11.6: aminopeptidase B

This is an abbreviated version!
For detailed information about aminopeptidase B, go to the full flat file.

Word Map on EC 3.4.11.6

Reaction

release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys =

Synonyms

AAP, ACE2, Aminopeptidase, aminopeptidase B, aminopeptidase, arginine, aminopeptidase-B, Ap-B, APB, Arg-AP, Arg/Lys aminopeptidase, ArgAP, arginine aminopeptidase, arginine-aminopeptidase, arginyl aminopeptidase, arginyl peptidase, arylamidase, arylamidase II, BSAP, chloride-dependent-basic aminopeptidase, Cl--activated arginine aminopeptidase, Cl--activated arinine aminopeptidase, Co(II)-Ap-B, ColAP, cold-active aminopeptidase, Cu(II)-Ap-B, cytosol aminopeptidase, cytosol aminopeptidase IV, DAP BII, dipeptidyl aminopeptidase BII, double-zinc aminopeptidase, EC 3.4.13.6, KAP, L-arginine aminopeptidase, L-RAP, LAPase, leukocyte-derived arginine aminopeptidase, LRAP, lysine-specific aminopeptidase, minopeptidase, More, protease IV, pumAPE, RAP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.6 aminopeptidase B

Activating Compound

Activating Compound on EC 3.4.11.6 - aminopeptidase B

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
acetate
-
activation
bacitracin
-
activation
cysteine
-
slight activation
diphosphate
-
activation in presence of low Cl- concentrations
dithiothreitol
E64
-
slight activation at 0.01-0.05 mM
L-Cys
5 mM, activation to 148% of control
NaCl
the enzyme requires a physiological concentration of NaCl (150 mM) for optimal activity
NaF
-
0.4 M activates the activity by 20%
phosphate
-
activation
sulfhydryl compounds
-
activation, enzyme I
TGF-beta1
-
activates aminopeptidase activity
-
additional information
-