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3.4.11.3: cystinyl aminopeptidase

This is an abbreviated version!
For detailed information about cystinyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.3

Reaction

Release of an N-terminal amino acid, Cys-/-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however =

Synonyms

alpha-Aminoacyl-peptide hydrolase, aminopeptidase, cystyl, AT4 receptor, CAP, CAP-I, CAP-II, CysAP, cysteine aminopeptidase, cystine aminopeptidase, Cystinyl aminopeptidase, cystinylaminopeptidase, cystyl aminopeptidase, cystyl-aminopeptidase, GP160, insulin regulated aminopeptidase, insulin-regulated aminopeptidase, insulin-regulated aminopeptidase IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, IRAP/P-LAP, L-cystine aminopeptidase, LCAP, LeuAP, leucine aminopeptidase/oxytocinase, leucyl-aminopeptidase, leucyl-cystinyl aminopeptidase, LNPEP, M1 aminopeptidase, OTase, oxytocin peptidase, oxytocinase, oxytocinase/insulin-regulated aminopeptidase, oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase LNPEP, P-LAP, P-LAP/IRAP, P-LAP/OTase, placental leucil aminopeptidase, Placental leucine aminopeptidase, placental leucine aminopeptidase/oxytocinase, placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase, vasopressinase, vasopresssinase, Vesicle protein of 165 kDa, Vp165, yscXVI

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.3 cystinyl aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.3 - cystinyl aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-L-Asp1-Val5-angiotensin II + H2O
beta-Asp1-Val5-angiotensin II
show the reaction diagram
-
transformation to beta form
-
ir
angiotensin III + H2O
?
show the reaction diagram
Arg-4-methylcoumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
arginine vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
Cys-4-nitroanilide + H2O
Cys + 4-nitroaniline
show the reaction diagram
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-alanine-p-nitroanilide + H2O
L-alanine + p-nitroaniline
show the reaction diagram
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Arg-vasopressin + H2O
L-Arg + vasopressin
show the reaction diagram
-
-
-
-
?
L-arginine-7-amido-4-methylcoumarin + H2O
L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-benzyl-L-Cys-2-naphthylamide + H2O
L-benzyl-L-Cys + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-benzyl-L-cysteine-p-nitroanilide + H2O
L-benzyl-L-cysteine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Cys-beta-naphthylamide + H2O
L-Cys + beta-naphthylamine
show the reaction diagram
L-cystine di-beta-naphthylamide + H2O
?
show the reaction diagram
L-cystine-di-beta-naphthylamide + 2 H2O
L-cystine + 2 beta-naphthylamine
show the reaction diagram
L-cystine-di-p-nitroanilide + H2O
L-cystine + p-nitroaniline
show the reaction diagram
L-Leu-2-naphthylamide + H2O
2-naphthylamine + L-Leu
show the reaction diagram
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
show the reaction diagram
L-Leu-enkephalin + H2O
L-Leu + enkephalin
show the reaction diagram
-
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-leucine-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-leucine-p-nitroanilide + H2O
L-leucine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-lysine-p-nitroanilide + H2O
L-lysine + p-nitroaniline
show the reaction diagram
L-methionine-p-nitroanilide + H2O
L-methionine + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Trp-2-naphthylamide + H2O
L-Trp + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Leu-4-methylcoumaryl-7-amide + H2O
Leu + 7-amino-4-methylcoumarin
show the reaction diagram
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
show the reaction diagram
-
-
-
?
leucyl-beta-naphthylamide + H2O
leucine + beta-naphthylamine
show the reaction diagram
-
-
-
?
LGGGGGL + H2O
L-Leu + GGGGGL
show the reaction diagram
hydrolysis of poly-glycine peptides, overview
-
-
?
Lys-4-methylcoumaryl-7-amide + H2O
Lys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
lysine-vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
Met-4-methylcoumaryl-7-amide + H2O
Met + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
oxytocin + H2O
?
show the reaction diagram
oxytocin + H2O
acyclic peptide + H2O
show the reaction diagram
Peptides + H2O
?
show the reaction diagram
-
enzyme plays a role in general metabolism of peptides during pregnancy
-
-
?
S-benzyl-Cys-4-methylcoumaryl-7-amide + H2O
S-benzyl-Cys + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
S-benzyl-cysteine-4-methylcoumarin 7-amide + H2O
S-benzyl-cysteine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O
S-benzyl-L-cysteine + p-nitroaniline
show the reaction diagram
somatostatin + H2O
?
show the reaction diagram
-
-
-
-
?
Vasopressin + H2O
?
show the reaction diagram
vasopressin + H2O
hydrolyzed vasopressin
show the reaction diagram
additional information
?
-