3.4.11.3: cystinyl aminopeptidase
This is an abbreviated version!
For detailed information about cystinyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.3
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3.4.11.3
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envelope
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pregnancy
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cd4
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epitope
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lymphocyte
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angiotensin
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vaccinia
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viruses
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women
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aminopeptidases
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hiv-1-infected
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humoral
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t-cells
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virion
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simian
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macaque
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hiv-specific
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immunodominant
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nef
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seroconversion
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chimpanzee
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anti-hiv-1
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seronegative
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insipidus
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syncytium
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prime-boost
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furin
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vaccinees
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seropositive
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vaccine-induced
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glut4-containing
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hiv-seronegative
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desmopressin
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shiv
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ddavp
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hiv-1iiib
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anti-cd4
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intrarectal
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sivmac239
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medicine
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alum
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seroconverted
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1-infected
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non-neutralizing
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diagnostics
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oligosaccharyltransferase
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virus-neutralizing
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cross-neutralizing
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pharmacology
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coreceptors
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cross-presentation
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nephrogenic
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radioimmunoprecipitation
- 3.4.11.3
- envelope
- pregnancy
- cd4
- epitope
- lymphocyte
- angiotensin
- vaccinia
- viruses
- women
- aminopeptidases
-
hiv-1-infected
-
humoral
- t-cells
- virion
-
simian
- macaque
-
hiv-specific
-
immunodominant
- nef
- seroconversion
- chimpanzee
-
anti-hiv-1
-
seronegative
- insipidus
-
syncytium
-
prime-boost
- furin
-
vaccinees
-
seropositive
-
vaccine-induced
-
glut4-containing
-
hiv-seronegative
- desmopressin
- shiv
-
ddavp
-
hiv-1iiib
-
anti-cd4
-
intrarectal
-
sivmac239
- medicine
-
alum
-
seroconverted
-
1-infected
-
non-neutralizing
- diagnostics
-
oligosaccharyltransferase
-
virus-neutralizing
-
cross-neutralizing
- pharmacology
-
coreceptors
-
cross-presentation
-
nephrogenic
-
radioimmunoprecipitation
Reaction
Release of an N-terminal amino acid, Cys-/-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however =
Synonyms
alpha-Aminoacyl-peptide hydrolase, aminopeptidase, cystyl, AT4 receptor, CAP, CAP-I, CAP-II, CysAP, cysteine aminopeptidase, cystine aminopeptidase, Cystinyl aminopeptidase, cystinylaminopeptidase, cystyl aminopeptidase, cystyl-aminopeptidase, GP160, insulin regulated aminopeptidase, insulin-regulated aminopeptidase, insulin-regulated aminopeptidase IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, IRAP/P-LAP, L-cystine aminopeptidase, LCAP, LeuAP, leucine aminopeptidase/oxytocinase, leucyl-aminopeptidase, leucyl-cystinyl aminopeptidase, LNPEP, M1 aminopeptidase, OTase, oxytocin peptidase, oxytocinase, oxytocinase/insulin-regulated aminopeptidase, oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase LNPEP, P-LAP, P-LAP/IRAP, P-LAP/OTase, placental leucil aminopeptidase, Placental leucine aminopeptidase, placental leucine aminopeptidase/oxytocinase, placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase, vasopressinase, vasopresssinase, Vesicle protein of 165 kDa, Vp165, yscXVI
ECTree
3.4.11.3 cystinyl aminopeptidaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.11.3 - cystinyl aminopeptidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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trophoblastic cell. Insulin induces enzyme expression in trophoblasts
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P-LAP is detected in all clear-cell adenocarcinomas
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P-LAP is detected in 15 of 17 endometrioid adenocarcinomas
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high activity in the inner mucosal lining of the ampulla segment of the Fallopian tube, lower level in the interstitial and isthmus
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highest concentration in the outer myometrial layer of the uterus, lower levels in the inner myometrial layer and in the luminal epithelium
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enzyme in soluble fraction, no activity detected in particulate fraction
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P-LAP is located in the periphery in early gestation, located in both the periphery and inner cells during mid-gestation, located only in inner cells in late gestation
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P-LAP is detected in 13 of 14 mucinous adenocarcinomas
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P-LAP is detected in 7 of 14 borderline tumors
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expression of the enzyme is increased during the differentiation of the cells into neuronal cells
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cystinyl aminopeptidase is 100% higher in the left than in the right prefrontal cortex
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tendency towards increased P-LAP expression with advancing grade is observed in serous adenocarcinomas
additional information
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low activity, enzyme in soluble fraction, no activity detected in particulate fraction
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during normal pregnancy, enzyme activity in maternal serum gradually increases to the maximum at near term
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type III integral membrane protein, converted to a soluble form existing in maternal serum by metalloproteases
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activity is greatly increased in rats with mammary tumors. The activity may be involved in the promotion and progression of breast cancer through oxytocin, vasopressin and/or renin-angiotensin system misregulation
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highly expressed in selected olfactory regions, in septal and hypothalamic nuclei, throughout the hippocampal formation and cerebral cortex, and in motor and motor associated nuclei. IRAP is expressed exclusively in neurons in these regions
AT4 receptor/IRAP is found in neurons in the cortex, hippocampus and basal ganglia
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P-LAP is an independent prognosticator of clinical outcome in patients with endometrial carcinoma. Assessment of the P-LAP status provides clinically useful prognostic information in patients with endometrial carcinoma
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the enzyme is suggested to be involved in reducing chemosensitivity and may be a therapeutic target in endometrial carcinoma
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immunodetection of enzyme with large 100-200 nm vesicles in hippocampal neurons
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cystinyl aminopeptidase is 300% higher in the left than in the right hippocampus
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colocalization with the potential in vivo substrates, oxytocin and vasopression
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treatment with cyclosporin increases the activity of cystyl aminopeptidase as well as neutral, basic, prolyl imino and pyroglutamyl soluble aminopeptidase in the renal cortex
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low activity, enzyme in soluble fraction, no activity detected in particulate fraction
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among hematopoietic cells in fetal liver only megakaryocytes show strong expression of P-LAP
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enzyme in soluble fraction, no activity detected in particulate fraction
expressed in magnocellular neurones of the supraoptic (SON) and paraventricular (PVN) nuclei
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high activity level in corpus albicans, lower activity throughout the ovarian cortex and the surrounding connective tissue
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enzyme in soluble fraction, no activity detected in particulate fraction
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in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus
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predominantly expressed in differentiated trophoblasts, syncytiotrophoblasts
placental trophoblasts. Vasopressinase is proportional to placental weight
T-tubule-enriched membrane fractions from quadriceps muscles isolated of fasting mice
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T-tubule-enriched membrane fractions from quadriceps muscles isolated of fasting mice
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blocking of alpha-1adrenoceptor by doxazosin increases enzyme activity in male, but not in female
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highest concentration in the outer myometrial layer of the uterus, lower levels in the inner myometrial layer and in the luminal epithelium
additional information
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no activity in soluble and particulate fraction of midbrain and hypophysis
additional information
evaluation of lnpep transcript abundance in the brain of sexually-mature pupfish reveals that lnpep mRNAs are elevated in the hypothalamus of socially subordinate females and males, and at lower abundance in the telencephalon of socially dominant males compared to dominant females. Comparison of tissue expression patterns for LNPEP enzyme mRNAs, overview
additional information
enzyme IRAP is highly expressed in brain areas associated with cognition and epilepsy, regions that also display the highest densities of sst2A receptor immunoreactivity. Immunohistochemic analysis, quantitative analysis of immunofluorescence
additional information
organ distribution in adult male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with or without treatment with captopril, overview. Soluble or membrane-bound activities are generally higher in SHR compared to WKY notably in hypothalamus and kidney than in the other tissues. Captopril mainly decreases CysAP in SHR whereas it increases in WKY. The distribution of soluble CysAP is more homogeneous among tissues of WKY than SHR. In contrast, the distribution of membrane-bound CysAP is more heterogeneous than soluble CysAP in both WKY and SHR
additional information
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enzyme IRAP is highly expressed in brain areas associated with cognition and epilepsy, regions that also display the highest densities of sst2A receptor immunoreactivity. Immunohistochemic analysis, quantitative analysis of immunofluorescence
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additional information
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organ distribution in adult male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with or without treatment with captopril, overview. Soluble or membrane-bound activities are generally higher in SHR compared to WKY notably in hypothalamus and kidney than in the other tissues. Captopril mainly decreases CysAP in SHR whereas it increases in WKY. The distribution of soluble CysAP is more homogeneous among tissues of WKY than SHR. In contrast, the distribution of membrane-bound CysAP is more heterogeneous than soluble CysAP in both WKY and SHR
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