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3.4.11.3: cystinyl aminopeptidase

This is an abbreviated version!
For detailed information about cystinyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.3

Reaction

Release of an N-terminal amino acid, Cys-/-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however =

Synonyms

alpha-Aminoacyl-peptide hydrolase, aminopeptidase, cystyl, AT4 receptor, CAP, CAP-I, CAP-II, CysAP, cysteine aminopeptidase, cystine aminopeptidase, Cystinyl aminopeptidase, cystinylaminopeptidase, cystyl aminopeptidase, cystyl-aminopeptidase, GP160, insulin regulated aminopeptidase, insulin-regulated aminopeptidase, insulin-regulated aminopeptidase IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, IRAP/P-LAP, L-cystine aminopeptidase, LCAP, LeuAP, leucine aminopeptidase/oxytocinase, leucyl-aminopeptidase, leucyl-cystinyl aminopeptidase, LNPEP, M1 aminopeptidase, OTase, oxytocin peptidase, oxytocinase, oxytocinase/insulin-regulated aminopeptidase, oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase LNPEP, P-LAP, P-LAP/IRAP, P-LAP/OTase, placental leucil aminopeptidase, Placental leucine aminopeptidase, placental leucine aminopeptidase/oxytocinase, placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase, vasopressinase, vasopresssinase, Vesicle protein of 165 kDa, Vp165, yscXVI

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.3 cystinyl aminopeptidase

KM Value

KM Value on EC 3.4.11.3 - cystinyl aminopeptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.529
Arg-4-nitroanilide
-
pH 7.4, 37°C, wild-type enzyme
0.022
arginine-4-methylcoumarin 7-amide
-
-
0.331
Cys-4-nitroanilide
-
pH 7.4, 37°C, wild-type enzyme
0.5
L-Ala-2-naphthylamide
-
-
1.43
L-alanine-p-nitroanilide
-
-
0.046
L-Arg-2-naphthylamide
-
-
0.0225
L-cysteine-nitroanilide
-
-
0.045 - 0.59
L-Leu-2-naphthylamide
0.15 - 0.25
L-Leu-4-nitroanilide
0.23 - 0.867
L-leucine-p-nitroanilide
0.43 - 3
L-Lysine-p-nitroanilide
0.83
L-methionine-p-nitroanilide
-
-
0.11
L-Phe-7-amido-4-methylcoumarin
-
-
0.029
L-Trp-2-naphthylamide
-
-
0.0225
Leu-4-methylcoumaryl-7-amide
-
pH 7.5, 37°C
0.243 - 0.9148
Leu-4-nitroanilide
0.36
leucyl-p-nitroanilide
-
pH 7.4
0.0107
lysine-vasopressin
-
-
0.0051
Oxytocin
-
-
0.0436
S-benzyl-Cys-4-methylcoumaryl-7-amide
-
pH 7.5, 37°C
0.006
S-benzyl-cysteine-4-methylcoumarin 7-amide
-
-
0.0056 - 0.45
S-benzyl-L-cysteine-p-nitroanilide
0.0017
Vasopressin
-
-
additional information
additional information
-