3.4.11.3: cystinyl aminopeptidase

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For detailed information about cystinyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.3

3.4.11.3

envelope

pregnancy

cd4

epitope

lymphocyte

angiotensin

vaccinia

viruses

women

aminopeptidases

hiv-1-infected

humoral

t-cells

virion

simian

macaque

hiv-specific

immunodominant

nef

seroconversion

chimpanzee

anti-hiv-1

seronegative

insipidus

syncytium

prime-boost

furin

vaccinees

seropositive

vaccine-induced

glut4-containing

hiv-seronegative

desmopressin

shiv

ddavp

hiv-1iiib

anti-cd4

intrarectal

sivmac239

medicine

alum

seroconverted

1-infected

non-neutralizing

diagnostics

oligosaccharyltransferase

virus-neutralizing

cross-neutralizing

pharmacology

coreceptors

cross-presentation

nephrogenic

radioimmunoprecipitation

Reaction

Release of an N-terminal amino acid, Cys-/-Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however =

Synonyms

alpha-Aminoacyl-peptide hydrolase, aminopeptidase, cystyl, AT4 receptor, CAP, CAP-I, CAP-II, CysAP, cysteine aminopeptidase, cystine aminopeptidase, Cystinyl aminopeptidase, cystinylaminopeptidase, cystyl aminopeptidase, cystyl-aminopeptidase, GP160, insulin regulated aminopeptidase, insulin-regulated aminopeptidase, insulin-regulated aminopeptidase IRAP, Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase, IRAP, IRAP/P-LAP, L-cystine aminopeptidase, LCAP, LeuAP, leucine aminopeptidase/oxytocinase, leucyl-aminopeptidase, leucyl-cystinyl aminopeptidase, LNPEP, M1 aminopeptidase, OTase, oxytocin peptidase, oxytocinase, oxytocinase/insulin-regulated aminopeptidase, oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase LNPEP, P-LAP, P-LAP/IRAP, P-LAP/OTase, placental leucil aminopeptidase, Placental leucine aminopeptidase, placental leucine aminopeptidase/oxytocinase, placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase, vasopressinase, vasopresssinase, Vesicle protein of 165 kDa, Vp165, yscXVI

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.11 Aminopeptidases

3.4.11.3 cystinyl aminopeptidase

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Results	in table
5	Activating Compound
11	AA Sequence
14	Application
1	CAS Registry Number
20	Cloned(Commentary)
3	Crystallization (Commentary)
1579	Disease/ Diagnostics
2	Expression
35	General Information
2	General Stability
98	IC50 Value
377	Inhibitors
70	Ki Value [mM]
53	KM Value [mM]
71	Localization
40	Metals/Ions
25	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
105	Organism
12	PDB ID
22	pH Optimum
1	pH Range
10	Posttranslational Modification
33	Protein Variants
16	Purification (Commentary)
1	Reaction
2	Reaction Type
103	Reference
203	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
141	Substrates and Products (Substrate)
10	Subunits
157	Synonyms
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.11.3 - cystinyl aminopeptidase

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0.2

1,10-phenanthroline

Cricetulus griseus

IC50: 0.2 mM. Inhibitory effect is substantially potentiated by both EDTA and EGTA. A combined and complete inhibition of the enzyme activity by 0.1 mM EDTA and 0.1 mM 1,10-phenanthroline can be prevented in the presence of 0.04-0.1 mM ZnCl2

667549