3.4.11.21: aspartyl aminopeptidase

This is an abbreviated version!
For detailed information about aspartyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.21

3.4.11.21

3.4.11.7

angiotensin

aminopeptidases

renin-angiotensin

angiotensinase

gluap

amastatin

alanyl

glutamyl-aminopeptidase

3.4.24.11

maltase-glucoamylase

cysap

aspartyl-aminopeptidase

pepes

arylamide

drug development

lactase-phlorizin

medicine

synthesis

Reaction

release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate =

Synonyms

AAP, acid aminopeptidase, acid peptidase, alpha-aspartyl dipeptidase, Aminopeptidase, aminopeptidase A, angiotensinase, APA, Ape4, Ape4 aspartyl aminopeptidase, Ape4 metalloprotease, Asp-AP, AspAP, aspartate aminopeptidase, aspartic aminopeptidase, aspartyl aminopeptidase, aspartyl(glutamyl)-specific aminopeptidase, aspartyl-AP, CNAG_01169, DAP, DNPEP, EC 3.4.11.7, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, L-aspartate aminopeptidase, Lb-PepA, Lc-PepA, M18 aspartyl aminopeptidase, M18AAP, More, PepA, peptidase E, PfM18AAP, PvM18AAP, soluble acid aminopeptidase, TgAAP, TGGT1_297970, Yhr113w

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.11 Aminopeptidases

3.4.11.21 aspartyl aminopeptidase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
2	Activating Compound
1576	AA Sequence
8	Application
1	CAS Registry Number
15	Cloned(Commentary)
1	Crystallization (Commentary)
88	Disease/ Diagnostics
8	Expression
28	General Information
1	General Stability
59	IC50 Value
164	Inhibitors
2	kcat/KM [mM/s]
10	Ki Value [mM]
21	KM Value [mM]
33	Localization
28	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
52	Organism
31	PDB ID
18	pH Optimum
6	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
16	Protein Variants
18	Purification (Commentary)
4	Reaction
3	Reaction Type
49	Reference
1	Renatured (Commentary)
59	Source Tissue
11	Specific Activity [micromol/min/mg]
113	Substrates and Products (Substrate)
25	Subunits
119	Synonyms
8	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
4	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Natural Substrates Products on EC 3.4.11.21 - aspartyl aminopeptidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Natural Substrate Search

angiotensin + H2O

Asp + des-Asp-angiotensin

5 entries

angiotensin II + H2O

Asp + angiotensin III

Rattus norvegicus

aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure

663814

Asp-Xaa + H2O

Asp + Xaa

Salmonella enterica subsp. enterica serovar Typhimurium

137171

aspartyl peptides + H2O

Asp + des-Asp-angiotensin

2 entries