3.4.11.21: aspartyl aminopeptidase

This is an abbreviated version!
For detailed information about aspartyl aminopeptidase, go to the full flat file.

Reaction

release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate =

Synonyms

AAP, acid aminopeptidase, acid peptidase, alpha-aspartyl dipeptidase, Aminopeptidase, aminopeptidase A, angiotensinase, APA, Ape4, Ape4 aspartyl aminopeptidase, Ape4 metalloprotease, Asp-AP, AspAP, aspartate aminopeptidase, aspartic aminopeptidase, aspartyl aminopeptidase, aspartyl(glutamyl)-specific aminopeptidase, aspartyl-AP, CNAG_01169, DAP, DNPEP, EC 3.4.11.7, glutamyl (aspartyl)-specific aminopeptidase A, glutamyl aminopeptidase, L-aspartate aminopeptidase, Lb-PepA, Lc-PepA, M18 aspartyl aminopeptidase, M18AAP, More, PepA, peptidase E, PfM18AAP, PvM18AAP, soluble acid aminopeptidase, TgAAP, TGGT1_297970, Yhr113w

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.11 Aminopeptidases

                3.4.11.21 aspartyl aminopeptidase

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Results	in table
2	Activating Compound
1576	AA Sequence
8	Application
1	CAS Registry Number
15	Cloned(Commentary)
1	Crystallization (Commentary)
88	Disease/ Diagnostics
8	Expression
28	General Information
1	General Stability
59	IC50 Value
164	Inhibitors
2	kcat/KM [mM/s]
10	Ki Value [mM]
21	KM Value [mM]
33	Localization
28	Metals/Ions
25	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
52	Organism
31	PDB ID
18	pH Optimum
6	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
16	Protein Variants
18	Purification (Commentary)
4	Reaction
3	Reaction Type
49	Reference
1	Renatured (Commentary)
59	Source Tissue
11	Specific Activity [micromol/min/mg]
113	Substrates and Products (Substrate)
25	Subunits
119	Synonyms
8	Temperature Optimum [°C]
3	Temperature Range [°C]
15	Temperature Stability [°C]
4	Turnover Number [1/s]

Application

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Application on EC 3.4.11.21 - aspartyl aminopeptidase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

6 entries

medicine

Rattus norvegicus

-

enzyme is not present in the urine of healthy rats, however, it is readily detected in the urine in rat models of mild and heavy proteinuria. Urinary levels correlate with the severity of proteinuria

731109

synthesis

Salmonella enterica subsp. enterica serovar Typhimurium

-

dipeptide sweeteners aspartame and alitame

137171

drug development

Toxoplasma gondii

S7UJV5

enzyme TgAAP deletion results in inhibition, but not abolition, of invasion and growth of Toxoplasma gondii in cell culture, thus indicating that the enzyme may be a promising adjunct target for anti-toxoplasma drug development

755445

drug development

Plasmodium falciparum

Q8I2J3

the M18 aspartyl aminopeptidase is a valid target to develop antimalarial drugs

753110

drug development

Plasmodium vivax

A0A1G4HB34

the M18 aspartyl aminopeptidase is a valid target to develop antimalarial drugs against the drug resistant strains of malaria parasite

752973

drug development

Toxoplasma gondii GT1

-

enzyme TgAAP deletion results in inhibition, but not abolition, of invasion and growth of Toxoplasma gondii in cell culture, thus indicating that the enzyme may be a promising adjunct target for anti-toxoplasma drug development

-

drug development

Toxoplasma gondii RH

-

enzyme TgAAP deletion results in inhibition, but not abolition, of invasion and growth of Toxoplasma gondii in cell culture, thus indicating that the enzyme may be a promising adjunct target for anti-toxoplasma drug development

-

drug development

Toxoplasma gondii ATCC 50853

-

enzyme TgAAP deletion results in inhibition, but not abolition, of invasion and growth of Toxoplasma gondii in cell culture, thus indicating that the enzyme may be a promising adjunct target for anti-toxoplasma drug development

-