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3.4.11.17: tryptophanyl aminopeptidase

This is an abbreviated version!
For detailed information about tryptophanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.17

Reaction

preferential release of N-terminal tryptophan =

Synonyms

7-DMATS, CdpNPT, FgaPT1, FtmPT1, L-tryptophan aminopeptidase, tryptophan aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.17 tryptophanyl aminopeptidase

Substrates Products

Substrates Products on EC 3.4.11.17 - tryptophanyl aminopeptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-amide + H2O
Ala + NH3
show the reaction diagram
Asn + H2O
Asp + NH3
show the reaction diagram
citrulline + H2O
? + ?
show the reaction diagram
-
-
-
ir
Gln + H2O
Glu + NH3
show the reaction diagram
His-Ala + H2O
His + Ala
show the reaction diagram
-
-
-
ir
His-Gly + H2O
His + Gly
show the reaction diagram
-
-
-
ir
His-Leu + H2O
His + Leu
show the reaction diagram
-
-
-
ir
His-Phe + H2O
His + Phe
show the reaction diagram
-
-
-
ir
L-citrulline + H2O
(2S)-2-amino-5-(carboxyamino)pentanoic acid + NH3
show the reaction diagram
-
22% of the activity with Trp-amide
-
-
?
Leu-Ala + H2O
Leu + Ala
show the reaction diagram
-
-
-
ir
Leu-amide + H2O
Leu + NH3
show the reaction diagram
Leu-Gly + H2O
Leu + Gly
show the reaction diagram
-
-
-
ir
Leu-Gly-Gly + H2O
Leu + Gly-Gly
show the reaction diagram
-
-
-
ir
Leu-Phe + H2O
Leu + Phe
show the reaction diagram
-
-
-
ir
Leu-Trp + H2O
Leu + Trp
show the reaction diagram
-
-
-
ir
Met-amide + H2O
Met + NH3
show the reaction diagram
Phe-amide + H2O
Phe + NH3
show the reaction diagram
Phe-Leu + H2O
Phe + Leu
show the reaction diagram
-
-
-
ir
Ser-amide + H2O
Ser + NH3
show the reaction diagram
-
7% of the activity with Trp-amide
-
-
?
Trp-Ala + H2O
Trp + Ala
show the reaction diagram
-
-
-
ir
Trp-amide + H2O
Trp + NH3
show the reaction diagram
Trp-Glu + H2O
Trp + Glu
show the reaction diagram
-
-
-
ir
Trp-Gly + H2O
Trp + Gly
show the reaction diagram
-
-
-
ir
Trp-Leu + H2O
Trp + Leu
show the reaction diagram
-
-
-
ir
Trp-Phe + H2O
Trp + Phe
show the reaction diagram
-
-
-
ir
Trp-Trp + H2O
Trp + Trp
show the reaction diagram
-
-
-
ir
Trp-Tyr + H2O
Trp + Tyr
show the reaction diagram
-
-
-
ir
Tyr-amide + H2O
Tyr + NH3
show the reaction diagram
Val-Ala + H2O
Val + Ala
show the reaction diagram
-
-
-
ir
Val-amide + H2O
Val + NH3
show the reaction diagram
Val-Gly-Gly + H2O
Val + Gly-Gly
show the reaction diagram
-
-
-
ir
additional information
?
-
-
generally relatively high affinity towards peptides with N-terminal Trp
-
-
?