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3.4.11.17: tryptophanyl aminopeptidase

This is an abbreviated version!
For detailed information about tryptophanyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.17

Reaction

preferential release of N-terminal tryptophan =

Synonyms

7-DMATS, CdpNPT, FgaPT1, FtmPT1, L-tryptophan aminopeptidase, tryptophan aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.17 tryptophanyl aminopeptidase

Inhibitors

Inhibitors on EC 3.4.11.17 - tryptophanyl aminopeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
27% inhibition at 1 mM
alpha,alpha'-dipyridyl
-
53% inhibition at 1 mM
Ca2+
-
CdpNPT shows 69.2% relative activity at 5 mM Ca2+
Co2+
-
7-DMATS, FgaPT1, and CdpNPT show 10.2%, 32.3%, and 46.9% relative activity at 5 mM Co2+, respectively
EDTA
-
CdpNPT and FtmPT1 are completely inhibited by 5 mM EDTA, 7-DMATS and FgaPT1 show 11.6% and 43.1% relative activity at 5 mM EDTA
Fe2+
-
CdpNPT and FtmPT1 show 34.2% and 42.8% relative activity at 5 mM Fe2+, 7-DMATS and FgaPT1 are completely inhibited by 5 mM Fe2+
K+
-
FtmPT1 shows 86.5% relative activity at 5 mM K+
Mn2+
-
7-DMATS shows 84.0% relative activity at 5 mM Mn2+, FgaPT1 shows 69.7% relative activity at 5 mM Mn2+
monoiodoacetate
-
25% inhibition at 1 mM
N-ethylmaleimide
Zn2+
-
7-DMATS, FgaPT1, CdpNPT, and FtmPT1 are completely inhibited by 5 mM Zn2+