3.4.11.10: bacterial leucyl aminopeptidase
This is an abbreviated version!
For detailed information about bacterial leucyl aminopeptidase, go to the full flat file.
Word Map on EC 3.4.11.10
Reaction
release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids =
Synonyms
AAP, Aeromonas proteolytica aminopeptidase, Aminopeptidase, aminopeptidase A, aminopeptidase A (bacteria), aminopeptidase Ap1, aminopeptidase II, AP-II, API, APII, AVP, bacterial leucine aminopeptidase, bacterial M17 aminopeptidase, BSAP, Bsu aminopeptidase, BsuAP, CGase, cysteinylglycinase, double-zinc aminopeptidase, extracellular aminopeptidase, FgLAP, HpM17AP, LAP, LAPII, leucine aminopeptidase, leucine aminopeptidase II, leucine APN, Leucyl aminopeptidase, M17 aminopeptidase, M17 metallo-aminopeptidase, More, MtLAP, PepA, Peptidase A, pepZ, PhpA, ribosomal-bound aminopeptidase, rLAP55, Rv2213, SSAP, TAP, TH-2, thermophilic aminopeptidase, thermostable leucine aminopeptidase, Vibrio aminopeptidase, VpAP, ywaD
ECTree
3.4.11.10 bacterial leucyl aminopeptidaseAdvanced search results
results (
results (KI Value
KI Value on EC 3.4.11.10 - bacterial leucyl aminopeptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
5.1 - 19.8
2,3-Butanedione
-
photochemical inactivation: effect only in the light, proportional to light intensity, modification of 5 Trp-, 3-4 Tyr-, 2 His- and 2Arg-residues, no photoinactivation in the absence of oxygen or in the presence of azide, protection also by Trp, Met, D-Met, L-2-thiol-His, 2-mercaptoethanol, Gly-Met
0.1
5-bromo-8-hydroxy-2-methylquinoline-7-sulfonamide
-
value above, pH 8, 25°C
0.1
5-bromo-8-hydroxy-N,2-dimethylquinoline-7-sulfonamide
-
value above, pH 8, 25°C
0.1
5-bromo-8-hydroxy-N,N,2-trimethylquinoline-7-sulfonamide
-
value above, pH 8, 25°C
0.1
5-chloro-8-hydroxy-N,N-dimethylquinoline-7-sulfonamide
-
value above, pH 8, 25°C
0.1
8-hydroxy-N,N-dimethylquinoline-5-sulfonamide
-
value above, pH 8, 25°C
0.000058
amastatin
-
reversible, slow, tight binding, transition state analog complex, stoichiometry of inhibition 1:1
0.0019
L-leucine
wild type enzyme, in 50 mM Tricine buffer, 1.0 mM ZnSO4, and 200 mM KCl, at pH 8.0 and 25°C
0.0055
L-leucine 4-nitroanilide
enzyme with 2 Co2+ or Zn2+ bound, pH 8.0, 25°C
0.0019
leucine phosphonic acid
wild type enzyme, in 50 mM Tricine buffer, 1.0 mM ZnSO4, and 200 mM KCl, at pH 8.0 and 25°C
1.8 - 2
methylglyoxal
-
photochemical inactivation: effect only in UV-light
0.0000025 - 0.000057
N-mercaptoacyl-leucyl-p-nitroaniline
-
synthethic inhibitor, and derivatives, spectroscopic study of slow-binding inhibition
-
additional information
additional information
kinetics with metal-bound enzyme variants
-
additional information
additional information
-
inhibition kinetics with Zn and/or Cd-containing enzyme, overview
-
