3.2.2.7: adenosine nucleosidase

This is an abbreviated version!
For detailed information about adenosine nucleosidase, go to the full flat file.

Reaction

Synonyms

adenosinase, adenosine hydrolase, ANase, N-ribosyladenine ribohydrolase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.2 Hydrolysing N-glycosyl compounds

                3.2.2.7 adenosine nucleosidase

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Results

in table

2

AA Sequence

1

CAS Registry Number

1

Cloned(Commentary)

1

Engineering

6

General Stability

23

Inhibitors

1

Ki Value [mM]

16

KM Value [mM]

2

Localization

10

Molecular Weight [Da]

48

Natural Substrates/ Products (Substrates)

1

Organic Solvent Stability

42

Organism

4

Pathway

14

pH Optimum

1

pH Range

2

pH Stability

12

Purification (Commentary)

3

Reaction

1

Reaction Type

42

Reference

47

Source Tissue

15

Specific Activity [micromol/min/mg]

6

Storage Stability

83

Substrates and Products (Substrate)

4

Subunits

4

Synonyms

1

Systematic Name

4

Temperature Optimum [°C]

1

Temperature Range [°C]

4

Temperature Stability [°C]

1

Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.2.2.7 - adenosine nucleosidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

11 entries

adenosine + H2O

6-aminopurine + D-ribofuranose

29 entries

additional information

?

-

8 entries

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Brassica oleracea

-

hydrolysis at the same rate as for adenosine

137113

-

137113

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Brassica oleracea

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137113

-

137113

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Camellia sinensis

-

3-4 times greater hydrolysis compared to adenosine

137109

-

137109

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Camellia sinensis

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137109

-

137109

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Hordeum vulgare

-

hydrolyzes at 96% of the rate of adenosine

137102

-

137102

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Hordeum vulgare

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137102

-

137102

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Hordeum vulgare

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137111

-

137111

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Lupinus luteus

-

one third lowered activity compared to adenosine as substrate

137099

-

137099

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Lupinus luteus

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137099

-

137099

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Solanum tuberosum

-

hydrolysis at the same rate as for adenosine

137112

-

137112

?

2'-deoxyadenosine + H2O

6-aminopurine + 2-deoxy-D-ribofuranose

Solanum tuberosum

-

6-aminopurine-9-2'-deoxy-beta-D-ribofuranoside

137112

-

137112

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Acacia dealbata

-

6-aminopurine-9-beta-D-ribofuranoside

137104

-

137104

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Brassica oleracea

-

6-aminopurine-9-beta-D-ribofuranoside

137113

-

137113

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Camellia sinensis

-

component of the purine salvage pathway

137101

-

137101

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Camellia sinensis

-

component of the purine salvage pathway

137109

-

137109

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Camellia sinensis

-

6-aminopurine-9-beta-D-ribofuranoside

137101

-

137101

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Camellia sinensis

-

6-aminopurine-9-beta-D-ribofuranoside

137109

-

137109

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Crithidia fasciculata

-

component of the purine salvage pathway

137108

-

137108

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Crithidia fasciculata

-

6-aminopurine-9-beta-D-ribofuranoside

137108

-

137108

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Fraxinus excelsior

-

6-aminopurine-9-beta-D-ribofuranoside

137104

-

137104

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Helianthus tuberosus

-

6-aminopurine-9-beta-D-ribofuranoside

137051

-

137051

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Hordeum vulgare

-

6-aminopurine-9-beta-D-ribofuranoside

137111

-

137111

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Hordeum vulgare

-

6-aminopurine-9-beta-D-ribofuranoside

137102

-

137102

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Hordeum vulgare

-

6-aminopurine-9-beta-D-ribofuranoside

137106

-

137106

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Larix decidua

-

6-aminopurine-9-beta-D-ribofuranoside

137104

-

137104

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Lupinus luteus

-

component of the purine salvage pathway

137099

-

137099

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Lupinus luteus

-

6-aminopurine-9-beta-D-ribofuranoside

137099

-

137099

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Lupinus luteus

-

6-aminopurine-9-beta-D-ribofuranoside

137110

-

137110

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Medicago sativa

-

involved in maintaining an active pool of S-adenosyl-L-methionine for transmethylation reactions

137100

-

137100

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Medicago sativa

-

6-aminopurine-9-beta-D-ribofuranoside

137100

-

137100

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Solanum lycopersicum

-

component of the purine salvage pathway

137103

-

137103

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Solanum lycopersicum

-

implicated in metabolism of cytokinins

137103

-

137103

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Solanum lycopersicum

-

6-aminopurine-9-beta-D-ribofuranoside

137103

-

137103

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Solanum tuberosum

-

6-aminopurine-9-beta-D-ribofuranoside

137112

-

137112

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Tilia cordata

-

6-aminopurine-9-beta-D-ribofuranoside

137104

-

137104

ir

adenosine + H2O

6-aminopurine + D-ribofuranose

Triticum aestivum

-

implicated in metabolism of cytokinins

137107

-

137107

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Triticum aestivum

-

6-aminopurine-9-beta-D-ribofuranoside

137107

-

137107

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Trypanosoma cruzi

-

component of the purine salvage pathway

137108

-

137108

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Trypanosoma cruzi

-

6-aminopurine-9-beta-D-ribofuranoside

137108

-

137108

?

adenosine + H2O

6-aminopurine + D-ribofuranose

Ulmus carpinifolia

-

6-aminopurine-9-beta-D-ribofuranoside

137104

-

137104

ir

additional information

?

-

Avicennia marina

-

56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway

657086

-

-

?

additional information

?

-

Bruguiera gymnorhiza

-

56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway

657086

-

-

?

additional information

?

-

Camellia sinensis

-

proposed pathway for biosynthesis of purine alkaloids with adenosine derived from SAM cycle

655545

-

-

?

additional information

?

-

Kandelia candel

-

56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway

657086

-

-

?

additional information

?

-

Lumnitzera racemosa

-

30% of adenosine taken up by leaf disks may be converted to salvage products

657086

-

-

?

additional information

?

-

Pemphis acidula

-

30% of adenosine taken up by leaf disks is hydrolysed to adenine

657086

-

-

?

additional information

?

-

Rhizophora stylosa

-

56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway

657086

-

-

?

additional information

?

-

Sonneratia alba

-

56-92% of adenosine taken up by leaf disks may be converted to salvage products, efficient adenosine salvage abilitiy in mangrove is coupled to high enzymic activity and is stimulated by salt, proposed metabolic pathway

657086

-

-

?