3.2.2.2: inosine nucleosidase
This is an abbreviated version!
For detailed information about inosine nucleosidase, go to the full flat file.
Word Map on EC 3.2.2.2
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3.2.2.2
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trypanosoma
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vivax
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salvage
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n-glycosidic
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hypoxanthine
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iminoribitols
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trypanocidal
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riboside
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isozyme-specific
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trypanosomiasis
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ribonucleosides
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anthracis
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xanthosine
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fasciculata
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crithidia
- 3.2.2.2
- trypanosoma
- vivax
-
salvage
-
n-glycosidic
- hypoxanthine
- iminoribitols
-
trypanocidal
- riboside
-
isozyme-specific
-
trypanosomiasis
- ribonucleosides
- anthracis
- xanthosine
- fasciculata
-
crithidia
Reaction
Synonyms
guanosine-inosine-preferring nucleoside N-ribohydrolase, inosinase, inosine hydrolase, inosine-adenosine-guanosine nucleoside hydrolase, inosine-guanosine nucleosidase, NSH2, nucleosidase, inosine, purine-specific nucleoside hydrolase
ECTree
3.2.2.2 inosine nucleosidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.2.2.2 - inosine nucleosidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-mercaptopurine riboside + H2O
6-mercaptopurine + D-ribose
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inhibitor and substrate
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-
?
adenosine + H2O
D-ribose + adenine
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after 1 h, the rate of adenosine cleavage is about 12.5%
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-
?
adenosine + H2O
D-ribose + adenine
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after 1 h, the rate of adenosine cleavage is about 12.5%
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-
?
guanosine + H2O
D-ribose + guanine
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after 1 h, the rate of guanosine cleavage is about 16%
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-
?
guanosine + H2O
D-ribose + guanine
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after 1 h, the rate of guanosine cleavage is about 16%
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-
?
guanosine + H2O
guanine + D-ribose
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guanosine is hydrolyzed 12% faster than inosine
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-
?
inosine + H2O
D-ribose + hypoxanthine
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isoform NSH2 shows highest hydrolysis capacity for inosine
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-
?
inosine + H2O
D-ribose + hypoxanthine
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best substrate
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-
?
inosine + H2O
hypoxanthine + D-ribose
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guanosine is hydrolyzed 12% faster than inosine
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-
?
additional information
?
-
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the pure recombinant protein exhibits highest hydrolase activity for uridine, followed by inosine and adenosine
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-
?
additional information
?
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adenosine and xanthosine are poor substrates. No substrate are: 2'-deoxyguanosine, 2'-deoxyinosine, 2'-methylguanosine, pyrimidine nucleosides and 5'-GMP
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-
?
