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3.2.2.15: DNA-deoxyinosine glycosylase

This is an abbreviated version!
For detailed information about DNA-deoxyinosine glycosylase, go to the full flat file.

Word Map on EC 3.2.2.15

Reaction

hypoxanthine-containing DNA
+
H2O
=
hypoxanthine
+
DNA containing an abasic site

Synonyms

bovine hypoxanthine-DNA glycosylase, deoxyribonucleic acid glycosylase, DNA(hypoxanthine) glycohydrolase, DNA(hypoxanthine)glycohydrolase, family 5 UDGb, hypoxanthine DNA glycosylase, hypoxanthine-DNA glycosylase, hypoxanthine-DNA-glycosylase, Phep_0752, SMUG2, UdgB, uracil DNA glycosylase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.15 DNA-deoxyinosine glycosylase

Reference

Reference on EC 3.2.2.15 - DNA-deoxyinosine glycosylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Karran, P.; Lindahl, T.
Hypoxanthine in deoxyribonucleic acid: generation by heat-induced hydrolysis of adenine residues and release in free form by a deoxyribonucleic acid glycosylase from calf thymus
Biochemistry
19
6005-6011
1980
Bos taurus, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Karran, P.; Lindahl, T.
Enzymatic excision of free hypoxanthine from polydeoxynucleotides and DNA containing deoxyinosine monophosphate residues
J. Biol. Chem.
253
5877-5879
1978
Escherichia coli
Manually annotated by BRENDA team
Cool, B.L.; Sirover, M.A.
Proliferation-dependent regulation of DNA-glycosylases in progeroid cells
Mutat. Res.
237
211-220
1990
Homo sapiens
Manually annotated by BRENDA team
Dianov, G.; Lindahl, T.
Preferential recognition of I-T base-pairs in the initiation of excision-repair by hypoxanthine-DNA glycosylase
Nucleic Acids Res.
19
3829-3833
1991
Bos taurus, Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Ishchenko, A.; Sinitsyna, O.; Krysanova, Z.; Vasyunina, E.; Saparbaev, M.; Sidorkina, O.; Nevinsky, G.
Age-dependent increase of 8-oxoguanine-, hypoxanthine-, and uracil-DNA glycosylase activities in liver extracts from OXYS rats with inherited overgeneration of free radicals and Wistar rats
Med. Sci. Monit.
9
16-24
2003
Rattus norvegicus
Manually annotated by BRENDA team
Srinath, T.; Bharti, S.K.; Varshney, U.
Substrate specificities and functional characterization of a thermo-tolerant uracil DNA glycosylase (UdgB) from Mycobacterium tuberculosis
DNA Repair
6
1517-1528
2007
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Xia, B.; Liu, Y.; Li, W.; Brice, A.; Dominy, B.; Cao, W.
Specificity and catalytic mechanism in family 5 uracil DNA glycosylase
J. Biol. Chem.
289
18413-18426
2014
Thermus thermophilus (Q5SJ65), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJ65)
Manually annotated by BRENDA team
Pang, P.; Yang, Y.; Li, J.; Wang, Z.; Cao, W.; Xie, W.
SMUG2 DNA glycosylase from Pedobacter heparinus as a new subfamily of the UDG superfamily
Biochem. J.
474
923-938
2017
Pedobacter heparinus (C6Y1J8), Pedobacter heparinus DSM 2366 (C6Y1J8)
Manually annotated by BRENDA team