3.2.2.14: NMN nucleosidase
This is an abbreviated version!
For detailed information about NMN nucleosidase, go to the full flat file.
Word Map on EC 3.2.2.14
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3.2.2.14
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pyridine
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nicotinic
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riboside
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salvage
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pyrophosphatase
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purine
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azotobacter
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typhimurium
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vinelandii
- 3.2.2.14
- pyridine
-
nicotinic
- riboside
-
salvage
- pyrophosphatase
- purine
-
azotobacter
- typhimurium
- vinelandii
Reaction
Synonyms
NaR nucleosidase, nicotinamide mononucleotidase, nicotinamide mononucleotide glycohydrolase, nicotinamide mononucleotide nucleosidase, NMN glycohydrolase, NMNase, NMNGhase
ECTree
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Inhibitors
Inhibitors on EC 3.2.2.14 - NMN nucleosidase
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5-phosphoribose 1-diphosphate
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PRPP, inorganic polyphosphates, affinity of 5-phosphoribose 1-pyrophosphate for the enzyme is dependent on the activator concentration , inhibition mechanism with 5-phosphoribose 1-pyrophosphate is competitive with GTP
adenosine
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addition of 1.4 mM, inhibition 54.7%
ADP-ribose
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addition of 1-1.4 mM, inhibition 74.4%
AMP
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addition of 1.4 mM AMP, inhibition 92.5%
D-ribose-5-phosphate
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addition of 1.4 mM, inhibition 42.3%
dCMP
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effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
desamido-NAD+
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addition of 1 mM, inhibition 66.6%
dGMP
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effective inhibition in presence of 1 mM GTP, noncompetitive inhibitor
guanosine
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addition of 1.4 mM, inhibition 44.6%
NAD+
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greatly inhibited by intracellular levels of NAD+ and reduced NADH, addition of 1 mM NAD+, inhibition 73.2%
NADH
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addition of 1 mM, inhibition 68.6%
NADP+
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addition of 1 mM, inhibition 24%
nicotinamide hypoxanthine dinucleotide
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addition of 1 mM nicotinamide hypoxanthine dinucleotide, inhibition 61.4%
pyridoxal 5'-phosphate
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addition of 1.4 mM, inhibition 8.8%
pyridoxal HCl
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addition of 1.4 mM, inhibition 5.2%
thio-NAD+
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addition of 1 mM, inhibition 63.2%
GMP
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addition of 1.4 mM GMP, inhibition 89.4%