3.2.1.49: alpha-N-acetylgalactosaminidase
This is an abbreviated version!
For detailed information about alpha-N-acetylgalactosaminidase, go to the full flat file.
Word Map on EC 3.2.1.49
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3.2.1.49
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n-acetylgalactosamine
-
sialidase
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fabry
-
schindler
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exoglycosidase
-
neuroaxonal
-
d3-binding
-
gcmaf
-
angiokeratoma
-
alpha-linked
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beta-galnac
-
macrophage-activating
-
pomatia
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corporis
-
diffusum
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biflorus
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mucin-type
-
medicine
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alpha-n-acetylgalactosaminyltransferase
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alpha-n-acetylgalactosamine
-
asialo
-
diagnostics
-
biotechnology
- 3.2.1.49
- n-acetylgalactosamine
- sialidase
- fabry
-
schindler
-
exoglycosidase
-
neuroaxonal
-
d3-binding
-
gcmaf
- angiokeratoma
-
alpha-linked
-
beta-galnac
-
macrophage-activating
- pomatia
-
corporis
- diffusum
- biflorus
-
mucin-type
- medicine
-
alpha-n-acetylgalactosaminyltransferase
- alpha-n-acetylgalactosamine
-
asialo
- diagnostics
- biotechnology
Reaction
Synonyms
2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase, 4-nitrophenyl-alpha-N-acetylgalactosaminidase, AglA, alpha-acetylgalactosaminidase, alpha-galactosidase B, alpha-GalNAc, alpha-GalNAc-ase, alpha-GalNAcase, alpha-GalNAcase I, alpha-GalNAcase II, alpha-N acetylgalactosaminidase, alpha-N-acetylgalactosaminidase blood group A2 degrading enzyme, alpha-N-galactosaminidase IV, alpha-NAGA, alpha-NAGAL, alpha-NaGalase, envelope glycoprotein gp160, exo-alpha-N-acetylgalactosaminidase, N-acetyl-alpha-D-galactosaminidase, N-acetyl-alpha-galactosaminidase, NagA, NaGalase
ECTree
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Substrates Products
Substrates Products on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase
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REACTION DIAGRAM
2-nitrophenyl 2-acetyl-2-deoxy-alpha-D-galactosamine + H2O
2-nitrophenol + 2-acetyl-2-deoxy-alpha-D-galactosamine
2-nitrophenyl alpha-D-fucopyranoside + H2O
2-nitrophenol + alpha-D-fucopyranose
-
-
-
-
?
2-nitrophenyl-alpha-D-galactoside + H2O
2-nitrophenol + alpha-D-galactose
-
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
4-methylumbelliferyl-alpha-D-galactopyranoside + H2O
4-methylumbelliferone + alpha-D-galactopyranose
4-methylumbelliferyl-alpha-D-galactosaminide + H2O
4-methylumbelliferone + alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside + H2O
4-nitrophenol + 2-acetamido-2-deoxy-alpha-D-galactopyranose
-
-
-
?
4-nitrophenyl alpha-D-N-acetylgalactosaminide + H2O
4-nitrophenol + N-acetyl-D-galactosamine
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-beta-D-galactosamine + H2O
4-nitrophenol + N-acetyl-beta-galactosamine
-
-
-
-
?
4-nitrophenyl-N-acetyl-alpha-D-galactosamide + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
GalNAc-alpha-1,3-GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide + H2O
alpha-N-acetylgalactosamine + GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide
globotriaosylceramide + H2O
?
wild-type and engineered mutant enzymes
-
-
?
o-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-galactosamine
o-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
o-nitrophenol + N-acetyl-D-galactosamine
p-nitrophenyl 2-acetamide-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside + H2O
p-nitrophenol + 2-acetamide-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside
-
-
-
-
?
p-nitrophenyl alpha-D-galactopyranoside + H2O
p-nitrophenol + alpha-D-galactopyranose
-
-
-
-
?
p-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
p-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
p-nitrophenol + N-acetyl-D-galactosamine
-
-
-
-
?
p-nitrophenyl-2-deoxy-alpha-D-galactopyranoside + H2O
p-nitrophenol + 2-deoxy-alpha-D-galactopyranose
-
-
-
-
?
p-nitrophenyl-alpha-N-acetyl-D-galactoaminide + H2O
p-nitrophenol + alpha-N-acetyl-D-galactosamine
-
the Hep-G2 cell lysate hydrolyzes the exo-type substrate
-
-
?
p-nitrophenyl-alpha-N-acetyl-D-galactosaminide + H2O
p-nitrophenol + alpha-N-acetyl-D-galactosamine
p-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
p-nitrophenol + alpha-N-acetylgalactosamine
p-nitrophenyl-N-acetyl-alpha-D-galactosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-galactosamine
phenyl-alpha-N-acetylglucosaminide + H2O
N-acetylgalactosamine + phenol
-
-
-
?
2-nitrophenol + 2-acetyl-2-deoxy-alpha-D-galactosamine
-
-
-
?
2-nitrophenyl 2-acetyl-2-deoxy-alpha-D-galactosamine + H2O
2-nitrophenol + 2-acetyl-2-deoxy-alpha-D-galactosamine
-
-
-
?
2-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
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enzyme acts with retention of the anomeric configuration
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
-
enzyme acts with retention of the anomeric configuration
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
?
2-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
2-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
?
4-methylumbelliferone + alpha-D-galactopyranose
-
-
-
-
?
4-methylumbelliferyl-alpha-D-galactopyranoside + H2O
4-methylumbelliferone + alpha-D-galactopyranose
substrate of engineered enzyme mutant S188E/A191L, not of the wild-type enzyme
-
-
?
4-nitrophenol + N-acetyl-D-galactosamine
-
-
-
-
?
4-nitrophenyl alpha-D-N-acetylgalactosaminide + H2O
4-nitrophenol + N-acetyl-D-galactosamine
-
-
-
-
?
4-nitrophenyl alpha-D-N-acetylgalactosaminide + H2O
4-nitrophenol + N-acetyl-D-galactosamine
substrate binding and active site structure, active-site interactions and ligand binding, overview. Inactive enzyme conformation, overview
-
-
?
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenyl alpha-N-acetylgalactosaminide + H2O
4-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
Arenibacter sp. KMM 6041
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
Formosa sp. KMM 6408
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenyl N-acetyl-alpha-D-galactosamine + H2O
4-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
4-nitrophenol + N-acetyl-galactosamine
-
-
-
?
4-nitrophenyl N-acetyl-D-galactosamine + H2O
4-nitrophenol + N-acetyl-galactosamine
-
-
-
-
?
?
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alpha-N-acetylgalactosaminidase blood group A2 degrading activity, substrate from human erythrocytes and plasma
-
-
?
blood group A glycoconjugate + H2O
?
-
alpha-N-acetylgalactosaminidase blood group A2 degrading activity, substrate from human and murine erythrocytes and plasma
-
-
?
alpha-N-acetylgalactosamine + GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide
-
i.e. Forssman hapten glycolipid, production of globoside by both isozymes
-
-
?
GalNAc-alpha-1,3-GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide + H2O
alpha-N-acetylgalactosamine + GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-beta-1,1-ceramide
-
i.e. Forssman hapten glycolipid
-
-
?
o-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
o-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
o-nitrophenol + N-acetyl-alpha-D-galactosamine
-
substrate from the blood type A2 antigen producing H antigen, blood type O
-
-
?
o-nitrophenol + N-acetyl-D-galactosamine
-
-
-
-
?
o-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
o-nitrophenol + N-acetyl-D-galactosamine
-
-
-
-
?
p-nitrophenol + alpha-N-acetyl-D-galactosamine
-
-
-
-
?
p-nitrophenyl-alpha-N-acetyl-D-galactosaminide + H2O
p-nitrophenol + alpha-N-acetyl-D-galactosamine
-
-
-
-
?
p-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
p-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
p-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
p-nitrophenyl-alpha-N-acetylgalactosaminide + H2O
p-nitrophenol + alpha-N-acetylgalactosamine
-
-
-
-
?
p-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
-
?
p-nitrophenyl-N-acetyl-alpha-D-galactosaminide + H2O
p-nitrophenol + N-acetyl-alpha-D-galactosamine
-
-
-
?
?
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i.e. Gc protein, human substrate, deglycosylation of the substrate
-
-
?
serum vitamin D3-binding protein + H2O
?
-
i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression
-
-
?
serum vitamin D3-binding protein + H2O
?
-
i.e. Gc protein, human substrate, deglycosylation of the substrate
-
-
?
?
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-
the enzyme glycosylizes free serine and threonine residues in the native and the N-tert-butoxycarbonyl-protected analogue protein to gain the Tn antigen. The enzyme catalyzes glycosylations yielding to a series of 2-acetamido-2-deoxy-alpha-D-galactobiosides using 2-acetamido-2-deoxy-D-galactopyranose as a glycosyl donor, identification of isomers alpha-D-GalpNAc-1,6-D-GalpNAc, alpha-D-GalpNAc-1,3-D-GalpNAc, and alpha-D-GalpNAc-1,6-D-GalfNAc
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-
?
additional information
?
-
preference for alpha-N-acetyl-D-galactosaminide over alpha-D-galactoside. alpha-N-acetylgalactosaminidase activity uses a retaining mechanism
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-
?
additional information
?
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an exoglycosidase specific for the hydrolysis of terminal alpha-linked N-acetylgalactosamine in various sugar chains
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-
?
additional information
?
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the enzyme also exhibits alpha-galactosidase activity
-
-
?
additional information
?
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an exoglycosidase specific for the hydrolysis of terminal alpha-linked N-acetylgalactosamine in various sugar chains
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-
?
additional information
?
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the enzyme also exhibits alpha-galactosidase activity
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-
?
additional information
?
-
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the enzyme hydrolyzes alpha-N-acetylgalactosyl residues from glycolipids and glycoproteins
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-
?
additional information
?
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the enzyme hydrolyzes the terminal N-actyl-alpha-D-galactosamine from the blood type A2 antigen producing H antigen, blood type O
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-
?
additional information
?
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the enzyme is highly selective for terminal N-acetylgalactosamine residues, sugars other than N-acetyl-alpha-D-galactosaminide are no substrates
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-
?
additional information
?
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the enzyme is highly selective for terminal N-acetylgalactosamine residues, sugars other than N-acetyl-alpha-D-galactosaminide are not substrates. the enzyme degrades blood A epitope
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-
?
additional information
?
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enzyme efficiently cleaves blood group A antigen. Unusual catalytic mechanism involving NAD+. NagA might adopt a mechanism similar to that of glycosyl hydrolase family 4 enzymes utilizing an oxidation-elimination-addition-reduction sequence
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-
?
additional information
?
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the enzyme catalyses the hydrolysis of aryl 2-acetamido-2-deoxy-alpha-D-galactopyranosides
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-
?
additional information
?
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Gal-beta-GalNAc-alpha-PNP is no substrate for Hep-G2 cell lysate, the enzyme of tumor cell lysate reduces the macrophage activing potency of GcMAF
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-
?
additional information
?
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the enzyme inactivates the macrophage activing factor produced from Gc protein and this results in reduced phagocytic activity and superoxide-generation capacity of monocytes/macrophages
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?
additional information
?
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the enzyme is highly selective for terminal N-acetylgalactosamine residues
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-
?
additional information
?
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enzyme deficiency, due to missense mutations at residue R329 causing structural changes in the enzyme leading to differing substrate specificity, causes the Kanzaki disease, an autosomal recessine storage disorder with accumulation of GalNAcalpha1-O-Ser/Thr in the lysosome and increased urinary excretion of O-linked sialylglycopeptides, phenotype, overview
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?
additional information
?
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alpha-NAGAL is a lysosomal exoglycosidase that cleaves terminal alpha-N-acetylgalactosamine residues from glycopeptides and glycolipids
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?
additional information
?
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alpha-NAGAL is a lysosomal exoglycosidase that cleaves terminal alpha-N-acetylgalactosamine residues from glycopeptides and glycolipids
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?
additional information
?
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the enzyme hydrolyzes alpha-N-acetylgalactosyl residues from glycolipids and glycoproteins
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-
?
additional information
?
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Ser188 and Ala191 play important roles in the recognition of an N-acetylgalactosamine residue in NAGA
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?
additional information
?
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Ser188 and Ala191 play important roles in the recognition of an N-acetylgalactosamine residue in NAGA
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?
additional information
?
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the enzyme also shows activity with 4-nitrophenyl alpha-D-galactosaminide
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?
additional information
?
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the enzyme also shows activity with 4-nitrophenyl alpha-D-galactosaminide
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?
additional information
?
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the enzyme plays a dual role in regulating both infectivity and immunosuppression
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?
additional information
?
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the HIV-1 viral envelope glycoprotein gp160 shows alpha-N-galactosaminidase activity
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?