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3.2.1.49: alpha-N-acetylgalactosaminidase

This is an abbreviated version!
For detailed information about alpha-N-acetylgalactosaminidase, go to the full flat file.

Word Map on EC 3.2.1.49

Reaction

alpha-D-GalNAc-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide
+
H2O
=
D-GalNAc
 +
beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide

Synonyms

2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase, 4-nitrophenyl-alpha-N-acetylgalactosaminidase, AglA, alpha-acetylgalactosaminidase, alpha-galactosidase B, alpha-GalNAc, alpha-GalNAc-ase, alpha-GalNAcase, alpha-GalNAcase I, alpha-GalNAcase II, alpha-N acetylgalactosaminidase, alpha-N-acetylgalactosaminidase blood group A2 degrading enzyme, alpha-N-galactosaminidase IV, alpha-NAGA, alpha-NAGAL, alpha-NaGalase, envelope glycoprotein gp160, exo-alpha-N-acetylgalactosaminidase, N-acetyl-alpha-D-galactosaminidase, N-acetyl-alpha-galactosaminidase, NagA, NaGalase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.49 alpha-N-acetylgalactosaminidase

Specific Activity

Specific Activity on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002
-
cell extract of gingival keratinocyte
0.0003
-
cell extract of gingival fibroblast
0.0004
-
cell extract of embryonic lung fibroblast
0.0012
-
pH 5.0, Chang liver cell
0.0021
-
pH 5.0, Hep-G2 cell
0.0026
-
pH 5.0, HCT116 cell
0.005
-
cell extract of gingival carcinoma
0.012
-
cell extract of salivary gland carcinoma
0.63
-
crude enzyme, strain KMM 6486, pH 7.3, 20°C
0.64
-
crude enzyme, pH 7.3, 20°C
0.65
-
crude enzyme, strain KMM 6484, pH 7.3, 20°C
0.79
-
crude enzyme, strain KMM 6489, pH 7.3, 20°C
0.83
-
crude enzyme, strain KMM 3961, pH 7.3, 20°C
0.84
Arenibacter sp. KMM 6041
-
crude enzyme, pH 7.3, 20°C
0.91
-
crude enzyme, strain KMM 6485, pH 7.3, 20°C
0.92
Formosa sp. KMM 6408
-
crude enzyme, pH 7.3, 20°C
1.38
-
crude enzyme, strain KMM 3952, pH 7.3, 20°C
1.7
-
crude enzyme, strain KMM 3528, pH 7.3, 20°C
1.8
-
crude enzyme, strain KMM 6483, pH 7.3, 20°C
1.83
-
crude enzyme, strain KMM 3980, pH 7.3, 20°C
19.56
-
purified isozyme alpha-GalNAcase I
2279
-
purified fraction from salivary gland carcinoma
24.2
-
purified isozyme alpha-GalNAcase II
3.1
substrate 2-nitrophenyl-alpha-D-galactoside, pH not specified in the publication, temperature not specified in the publication
4.5
-
purified placental enzyme
5.1
-
crude enzyme, strain KMM 3523, pH 7.3, 20°C
5.5
-
crude enzyme, strain KMM 6488, pH 7.3, 20°C
51.2
-
recombinant enzyme
56.4
-
native enzyme
8.33
purified recombinant enzyme mutant
84110
-
purified recombinant enzyme
additional information