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3.2.1.49: alpha-N-acetylgalactosaminidase

This is an abbreviated version!
For detailed information about alpha-N-acetylgalactosaminidase, go to the full flat file.

Word Map on EC 3.2.1.49

Reaction

alpha-D-GalNAc-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide
+
H2O
=
D-GalNAc
 +
beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide

Synonyms

2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase, 4-nitrophenyl-alpha-N-acetylgalactosaminidase, AglA, alpha-acetylgalactosaminidase, alpha-galactosidase B, alpha-GalNAc, alpha-GalNAc-ase, alpha-GalNAcase, alpha-GalNAcase I, alpha-GalNAcase II, alpha-N acetylgalactosaminidase, alpha-N-acetylgalactosaminidase blood group A2 degrading enzyme, alpha-N-galactosaminidase IV, alpha-NAGA, alpha-NAGAL, alpha-NaGalase, envelope glycoprotein gp160, exo-alpha-N-acetylgalactosaminidase, N-acetyl-alpha-D-galactosaminidase, N-acetyl-alpha-galactosaminidase, NagA, NaGalase

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.49 alpha-N-acetylgalactosaminidase

Reference

topprint

Reference on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dean, K.J.; Sweeley, C.C.
Studies on human liver alpha-galactosidase. II Purification and enzymatic properties of alpha-Galactosidas B (alpha-N-acetylgalactosaminidase)
J. Biol. Chem.
254
10001-10005
1979
Homo sapiens
Manually annotated by BRENDA team
Dean, K.J.; Sweeley, C.C.
Studies on human liver alpha-galactosidases. III. Partial characterization of carbohydrate-binding specificities
J. Biol. Chem.
254
10006-10010
1979
Homo sapiens
Manually annotated by BRENDA team
Salvayre, R.; Maret, A.; Negre, A.; Douste-Blazy, L.
Properties of multiple molecular forms of alpha-galactosidase and alpha-N-acetylgalactosaminidase from normal and fabry leukocytes
Eur. J. Biochem.
100
377-383
1979
Homo sapiens
Manually annotated by BRENDA team
Kadowaki, S.; Ueda, T.; Yamamoto, K.; Kumagai, H.; Tochikura, T.
Isolation and characterization of a blood group A substance-degrading alpha-N-acetylgalactosaminidase from an Acremonium sp.
Agric. Biol. Chem.
53
111-120
1989
Acremonium sp.
-
Manually annotated by BRENDA team
Nakagawa, H.; Asakawa, M.; Enomoto, N.
Purification and characterization of alpha-N-acetylgalactosaminidase from skipjack liver
J. Biochem.
101
855-862
1987
Katsuwonus pelamis
Manually annotated by BRENDA team
Chien, S.F.
Purification and characterization of alpha-N-acetylgalactosaminidase from shrimp hepatopancreas
J. Chin. Biochem. Soc.
15
86-96
1986
Solenocera melantho
-
Manually annotated by BRENDA team
Williams, A.G.; Withers, S.E.; Coleman, G.S.
Glycoside hydrolase of rumen bacteria and protozoa
Curr. Microbiol.
10
287-294
1984
Ruminobacter amylophilus, Bacteroides fragilis, Fibrobacter succinogenes, Butyrivibrio fibrisolvens, Entodinium caudatum, Entodinium simplex, Epidinium caudatum, Eremoplastron bovis, Eudiplodinium maggii, Lachnospira multipara, Megasphaera elsdenii, Ruminococcus albus, Ruminococcus flavefaciens, Selenomonas ruminantium, Streptococcus equinus, Succinivibrio dextrinosolvens
-
Manually annotated by BRENDA team
Itoh, T.; Uda, Y.
alpha-N-Acetylgalactosaminidase from squid liver: purification and characterization of two enzymes
J. Biochem.
95
959-970
1984
Todarodes pacificus
Manually annotated by BRENDA team
Sweeley, C.C.; Ledonne, N.C.; Robbins, P.W.
Post-translational processing reactions involved in the biosynthesis of lysosomal alpha-N-acetylgalactosaminidase in cultured human fibroblasts
Arch. Biochem. Biophys.
223
158-165
1983
Homo sapiens
Manually annotated by BRENDA team
Salvayre, R.; Negre, A.; Maret, A.; Lenoir, G.; Douste-Blazy, L.
Separation and properties of molecular forms of alpha-galactosidase and alpha-N-acetylgalactosaminidase from blood lymphocytes and lymphoid cell lines transformed by Epstein-Barr virus
Biochim. Biophys. Acta
659
445-456
1981
Homo sapiens
Manually annotated by BRENDA team
Levy, G.N.; Aminoff, D.
Purification and properties of alpha-N-acetylgalactosaminidase from Clostridium perfringens
J. Biol. Chem.
255
11737-11742
1980
Clostridium perfringens
Manually annotated by BRENDA team
Sung, S.S.J.; Sweely, C.C.
Purification and partial characterization of porcine liver alpha-N-acetylgalactosaminidase
J. Biol. Chem.
255
6589-6594
1980
Sus scrofa
Manually annotated by BRENDA team
Dean, K.J.; Sung, S.S.J.; Sweeley, C.C.
The identification of alpha-galactosidase B from human liver as an alpha-N-acetylgalactosaminidase
Biochem. Biophys. Res. Commun.
77
1411-1417
1977
Homo sapiens
Manually annotated by BRENDA team
Uda, Y.; Li, S.C.; Li, Y.T.
alpha-N-Acetylgalactosaminidase from the limpet, Patella vulgata
J. Biol. Chem.
252
5194-5200
1977
Patella vulgata
Manually annotated by BRENDA team
Callahan, J.W.; Lassila, E.L.; den Tandt, W.; Philippart, M.
alpha-N-Acetylgalactosaminidase: isolation, properties and distribution of the human enzyme
Biochem. Med.
7
424-431
1973
Homo sapiens
Manually annotated by BRENDA team
Weissmann, B.; Hinrichsen, D.F.
Mammalian alpha-acetylgalactosaminidase. Occurrence, partial purification, and action on linkages in submaxillary mucins
Biochemistry
8
2034-2043
1969
Bos taurus, Sus scrofa
Manually annotated by BRENDA team
Werries, E.; Wollek, E.; Gottschalk, A.; Buddecke, E.
Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase
Eur. J. Biochem.
10
445-449
1969
Bos taurus
Manually annotated by BRENDA team
Tuppy, H.; Staudenbauer, W.L.
The action on soluble blood group A substances of an alpha-N-acetylgalactosaminidase from Helix pomatia
Biochemistry
5
1742-1747
1966
Helix pomatia
Manually annotated by BRENDA team
Yagi, F.; Eckhardt, A.E.; Goldstein, I.J.
Gycosidases of Ehrlich ascites tumor cells and ascitic fluid-purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha galactosidase
Arch. Biochem. Biophys.
280
61-67
1990
Homo sapiens
Manually annotated by BRENDA team
Hata, J.; Dhar, M.; Mitra, M.; Harmata, M.; Haibach, P.; Sun, P.; Smith, D.
Purification and characterization of N-acetyl-alpha-D-galactosaminidase from Gallus domesticus
Biochem. Int.
28
77-86
1992
Gallus gallus
Manually annotated by BRENDA team
Zhu, A.; Goldstein, J.
Cloning and characterization of a cDNA encoding chicken liver alpha-N-acetylgalactosaminidase
Gene
137
309-314
1993
Gallus gallus
Manually annotated by BRENDA team
Zhu, A.; Monahan c.; Wang Z.; Goldstein J.
Expression, purification and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris
Protein Expr. Purif.
8
456-462
1996
Gallus gallus
Manually annotated by BRENDA team
Den Tandt, W.R.; Scharpe, S.
Micromethod for the fluorimetric determination of plasma N-acetyl-alpha-galactosaminidase and study of some of its characteristics
Enzyme Protein
49
273-280
1996
Homo sapiens
Manually annotated by BRENDA team
Hoskins, L.C.; Boulding, E.T.; Larson G.
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70
J. Biol. Chem.
272
7932-7939
1997
[Ruminococcus] torques
Manually annotated by BRENDA team
Naundorf, A.; Ajisaka, K.
Purification of alpha-N-acetylgalactosaminidase from Aspergillus niger and its use in the synthesis of GalNAc-alpha-(1 O)-serine
Enzyme Microb. Technol.
25
483-488
1999
Aspergillus niger
-
Manually annotated by BRENDA team
Hermann, T.; Schindler, D.; Tabe, H.; Onadera, O.; Igarashi, S.; Polack, A.; Zehnpfennig, D.; Tsuji S.
Molecular cloning, structural organization, sequence, chromosomal assignment, and expression of the mouse alpha-N-acetylgalactosaminidase gene
Gene
211
205-214
1998
Mus musculus
Manually annotated by BRENDA team
Wang, A.M.; Ioannou, Y.A.; Zeidner, K.M.; Desnick, R.J.
Murine alpha-N-acetylgalactosaminidase: Isolation and expression of a full-lenght cDNA and genomic organization: further evidence of an alpha galactosidase gene family
Mol. Genet. Metab.
65
165-173
1998
Mus musculus (Q9QWR8), Mus musculus
Manually annotated by BRENDA team
Bakunina, I.Y.; Kuhlmann, R.A.; Likhosherstov, L.M.; Martynova, M.D.; Nedashkovskaya, O.I.; Mikhailov, V.V.; Elyakova, L.A.
Alpha-N-acetylgalactosaminidase from marine bacterium Arenibacter latericius KMM 426T removing blood type specificity of A-erythrocytes
Biochemistry
67
689-695
2002
Arenibacter latericius, Arenibacter latericius KMM 426
Manually annotated by BRENDA team
Hsieh, H.Y.; Smith, D.
Clostridium perfringens alpha-N-acetylgalactosaminidase blood group A2-degrading activity
Biotechnol. Appl. Biochem.
37
157-163
2003
Clostridium perfringens
Manually annotated by BRENDA team
Mohamad, S.B.; Nagasawa, H.; Uto, Y.; Hori, H.
Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation
Comp. Biochem. Physiol. A
132
1-8
2002
Homo sapiens
Manually annotated by BRENDA team
Calcutt, M.J.; Hsieh, H.Y.; Chapman, L.F.; Smith, D.S.
Identification, molecular cloning and expression of an alpha-N-acetylgalactosaminidase gene from Clostridium perfringens
FEMS Microbiol. Lett.
214
77-80
2002
Clostridium perfringens (Q8XNK8), Clostridium perfringens
Manually annotated by BRENDA team
Ohta, M.; Ohnishi, T.; Ioannou, Y.A.; Hodgson, M.E.; Matsuura, F.; Desnick, R.J.
Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides
Glycobiology
10
251-261
2000
Homo sapiens
Manually annotated by BRENDA team
Matsuura, T.; Uematsu, T.; Yamaoka, M.; Furusawa, K.
Effect of salivary gland adenocarcinoma cell-derived alpha-N-acetylgalactosaminidase on the bioactivity of macrophage activating factor
Int. J. Oncol.
24
521-528
2004
Homo sapiens
Manually annotated by BRENDA team
Hsieh, H.Y.; Mitra, M.; Wells, D.C.; Smith, D.
Purification and characterization of alpha-N-acetylgalactosaminidase from Clostridium perfringens
IUBMB Life
50
91-97
2000
Clostridium perfringens
Manually annotated by BRENDA team
Hsieh, H.Y.; Calcutt, M.J.; Chapman, L.F.; Mitra, M.; Smith, D.S.
Purification and characterization of a recombinant alpha-N-acetylgalactosaminidase from Clostridium perfringens
Protein Expr. Purif.
32
309-316
2003
Clostridium perfringens
Manually annotated by BRENDA team
Garman, S.C.; Hannick, L.; Zhu, A.; Garboczi, D.N.
The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases
Structure
10
425-434
2002
Gallus gallus
Manually annotated by BRENDA team
Yamamoto, N.
Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the envelope glycoprotein gp160 of human immunodeficiency virus Type 1
AIDS Res. Hum. Retroviruses
22
262-271
2006
Human immunodeficiency virus 1, Homo sapiens
Manually annotated by BRENDA team
Hsieh, H.; Chapman, L.F.; Calcutt, M.J.; Mitra, M.; Smith, D.S.
Recombinant Clostridium perfringens alpha-N-acetylgalactosaminidase blood group A2 degrading activity
Artif. Cells Blood Substit. Immobil. Biotechnol.
33
187-199
2005
Clostridium perfringens
Manually annotated by BRENDA team
Kanekura, T.; Sakuraba, H.; Matsuzawa, F.; Aikawa, S.; Doi, H.; Hirabayashi, Y.; Yoshii, N.; Fukushige, T.; Kanzaki, T.
Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and clinical phenotypes
J. Dermatol. Sci.
37
15-20
2005
Homo sapiens
Manually annotated by BRENDA team
Weignerova, L.; Filipi, T.; Manglova, D.; Kren, V.
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus niger
Appl. Microbiol. Biotechnol.
79
769-774
2008
Aspergillus niger, Aspergillus niger CCIM K2
Manually annotated by BRENDA team
Tajima, Y.; Kawashima, I.; Tsukimura, T.; Sugawara, K.; Kuroda, M.; Suzuki, T.; Togawa, T.; Chiba, Y.; Jigami, Y.; Ohno, K.; Fukushige, T.; Kanekura, T.; Itoh, K.; Ohashi, T.; Sakuraba, H.
Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease
Am. J. Hum. Genet.
85
569-580
2009
Homo sapiens (P17050), Homo sapiens
Manually annotated by BRENDA team
Weignerova¡, L.; Pelantova¡, H.; Manglova¡, D.; Michalkova¡, K.; Kren, V.
Condensation reactions catalyzed by alpha-N-acetylgalactosaminidase from Aspergillus niger yielding alpha-N-acetylgalactosaminides
Biocatal. Biotransform.
28
150-155
2010
Aspergillus niger
-
Manually annotated by BRENDA team
Sadik, G.; or Rashid, M.H.; Itoh-Nashida, T.; Ishii, K.; Sato, Y.; Shiraishi, T.; Uda, Y.
Chemical and immunological characterization of the two alpha-N-acetylgalactosaminidases from squid liver
Biol. Pharm. Bull.
32
1469-1472
2009
Architeuthis sp.
Manually annotated by BRENDA team
Harun-Or-Rashid, M.; Matsuzawa, T.; Satoh, Y.; Shiraishi, T.; Ando, M.; Sadik, G.; Uda, Y.
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis
Biosci. Biotechnol. Biochem.
74
256-261
2010
Homo sapiens, Asterina amurensis
Manually annotated by BRENDA team
Greco, M.; Mitri, M.D.; Chiriaco, F.; Leo, G.; Brienza, E.; Maffia, M.
Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity
Cancer Lett.
283
222-229
2009
Homo sapiens
Manually annotated by BRENDA team
Clark, N.E.; Garman, S.C.
The 1.9 A structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases
J. Mol. Biol.
393
435-447
2009
Homo sapiens (P17050), Homo sapiens
Manually annotated by BRENDA team
Sulzenbacher, G.; Liu, Q.; Bennett, E.; Levery, S.; Bourne, Y.; Ponchel, G.; Clausen, H.; Henrissat, B.
A novel alpha-N-acetylgalactosaminidase family with an NAD+-dependent catalytic mechanism suitable for enzymatic removal of blood group A antigens
Biocatal. Biotransform.
28
22-32
2010
Elizabethkingia meningoseptica (A4Q8F7)
-
Manually annotated by BRENDA team
Kulik, N.; Weignerova, L.; Filipi, T.; Pompach, P.; Novak, P.; Mrazek, H.; Slamova, K.; Bezouska, K.; Kren, V.; Ettrich, R.
The alpha-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional alpha-N-acetylgalactosaminidase
Glycobiology
20
1410-1419
2010
Aspergillus niger (A2QL72)
Manually annotated by BRENDA team
Mrazek, H.; Benada, O.; Man, P.; Vanek, O.; K?en, V.; Bezouska, K.; Weignerova, L.
Facile production of Aspergillus niger alpha-N-acetylgalactosaminidase in yeast
Protein Expr. Purif.
81
106-114
2011
Aspergillus niger (G5D7B5), Aspergillus niger CCIM K2 (G5D7B5)
Manually annotated by BRENDA team
Gao, H.; Li, S.; Bao, G.; Zhang, X.; Li, H.; Wang, Y.; Tan, Y.; Ji, S.; Gong, F.
Glucose buffer is suitable for blood group conversion with alpha-N acetylgalactosaminidase and alpha-galactosidase
Blood Transfus.
12
61-66
2014
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Chakladar, S.; Shamsi Kazem Abadi, S.; Bennet, A.
A mechanistic study on the alpha-N-acetylgalactosaminidase from E. meningosepticum: A family 109 glycoside hydrolase
MedChemComm
5
1188-1192
2014
Elizabethkingia meningoseptica
-
Manually annotated by BRENDA team
Bakunina, I.; Nedashkovskaya, O.; Kim, S.; Zvyagintseva, T.; Mikhailov, V.
Distribution of alpha-N-acetylgalactosaminidases among marine bacteria of the phylum Bacteroidetes, epiphytes of marine algae of the Seas of Okhotsk and Japan
Microbiology (Russian Federation)
81
373-378
2012
Arenibacter latericius, Maribacter sp., Cellulophaga sp., Formosa sp. KMM 6408, Kriegella aquimaris, Zobellia laminariae, Arenibacter palladensis, Arenibacter sp. KMM 6041, Arenibacter palladensis KMM 3961, Maribacter sp. KMM 6487, Maribacter sp. KMM 6486, Maribacter sp. KMM 6485, Maribacter sp. KMM 6484, Arenibacter palladensis KMM 3980, Kriegella aquimaris KMM 3942, Zobellia laminariae KMM 6205, Arenibacter latericius KMM 3523, Arenibacter latericius KMM 3528, Cellulophaga sp. KMM 6488, Cellulophaga sp. KMM 6483, Maribacter sp. KMM 6489, Maribacter sp. KMM 3952
-
Manually annotated by BRENDA team
Molafilabi, A.; Shahabi, M.; Rafatpanah, H.; Mashkani, B.
Production of universal group O red blood cells by alpha-N-acetylgalactosaminidase enzyme expressed in Pichia pastoris
Indian J. Hematol. Blood Transfus.
35
125-130
2019
Elizabethkingia meningoseptica (A4Q8F7)
Manually annotated by BRENDA team
Meshach Paul, D.; Rajasekaran, R.
Exploration of structural and functional variations owing to point mutations in alpha-NAGA
Interdiscip. Sci.
10
81-92
2018
Homo sapiens (P17050)
Manually annotated by BRENDA team
Cao, H.T.T.; Mikkelsen, M.D.; Lezyk, M.J.; Bui, L.M.; Tran, V.T.T.; Silchenko, A.S.; Kusaykin, M.I.; Pham, T.D.; Truong, B.H.; Holck, J.; Meyer, A.S.
Novel enzyme actions for sulphated galactofucan dpolymerisation and a new engineering strategy for molecular stabilisation of fucoidan degrading enzymes
Mar. Drugs
16
422
2018
Homo sapiens (P17050)
Manually annotated by BRENDA team
Bakunina, I.; Chadova, O.; Malyarenko, O.; Ermakova, S.
The effect of fucoidan from the brown alga Fucus evanescence on the activity of alpha-N-acetylgalactosaminidase of human colon carcinoma cells
Mar. Drugs
16
E155
2018
Homo sapiens (P17050), Homo sapiens
Manually annotated by BRENDA team