3.2.1.49: alpha-N-acetylgalactosaminidase
This is an abbreviated version!
For detailed information about alpha-N-acetylgalactosaminidase, go to the full flat file.
Word Map on EC 3.2.1.49
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3.2.1.49
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n-acetylgalactosamine
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sialidase
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fabry
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schindler
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exoglycosidase
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neuroaxonal
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d3-binding
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gcmaf
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angiokeratoma
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alpha-linked
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beta-galnac
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macrophage-activating
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pomatia
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corporis
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diffusum
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biflorus
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mucin-type
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medicine
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alpha-n-acetylgalactosaminyltransferase
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alpha-n-acetylgalactosamine
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asialo
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diagnostics
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biotechnology
- 3.2.1.49
- n-acetylgalactosamine
- sialidase
- fabry
-
schindler
-
exoglycosidase
-
neuroaxonal
-
d3-binding
-
gcmaf
- angiokeratoma
-
alpha-linked
-
beta-galnac
-
macrophage-activating
- pomatia
-
corporis
- diffusum
- biflorus
-
mucin-type
- medicine
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alpha-n-acetylgalactosaminyltransferase
- alpha-n-acetylgalactosamine
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asialo
- diagnostics
- biotechnology
Reaction
Synonyms
2-acetamido-2-deoxy-alpha-D-galactoside acetamidodeoxygalactohydrolase, 4-nitrophenyl-alpha-N-acetylgalactosaminidase, AglA, alpha-acetylgalactosaminidase, alpha-galactosidase B, alpha-GalNAc, alpha-GalNAc-ase, alpha-GalNAcase, alpha-GalNAcase I, alpha-GalNAcase II, alpha-N acetylgalactosaminidase, alpha-N-acetylgalactosaminidase blood group A2 degrading enzyme, alpha-N-galactosaminidase IV, alpha-NAGA, alpha-NAGAL, alpha-NaGalase, envelope glycoprotein gp160, exo-alpha-N-acetylgalactosaminidase, N-acetyl-alpha-D-galactosaminidase, N-acetyl-alpha-galactosaminidase, NagA, NaGalase
ECTree
3.2.1.49 alpha-N-acetylgalactosaminidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.2.1.49 - alpha-N-acetylgalactosaminidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
blood group A glycoconjugate + H2O
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alpha-N-acetylgalactosaminidase blood group A2 degrading activity, substrate from human erythrocytes and plasma
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serum vitamin D3-binding protein + H2O
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i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression
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?
additional information
?
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an exoglycosidase specific for the hydrolysis of terminal alpha-linked N-acetylgalactosamine in various sugar chains
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?
additional information
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an exoglycosidase specific for the hydrolysis of terminal alpha-linked N-acetylgalactosamine in various sugar chains
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?
additional information
?
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the enzyme hydrolyzes alpha-N-acetylgalactosyl residues from glycolipids and glycoproteins
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?
additional information
?
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enzyme deficiency, due to missense mutations at residue R329 causing structural changes in the enzyme leading to differing substrate specificity, causes the Kanzaki disease, an autosomal recessine storage disorder with accumulation of GalNAcalpha1-O-Ser/Thr in the lysosome and increased urinary excretion of O-linked sialylglycopeptides, phenotype, overview
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additional information
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alpha-NAGAL is a lysosomal exoglycosidase that cleaves terminal alpha-N-acetylgalactosamine residues from glycopeptides and glycolipids
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additional information
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alpha-NAGAL is a lysosomal exoglycosidase that cleaves terminal alpha-N-acetylgalactosamine residues from glycopeptides and glycolipids
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additional information
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the enzyme hydrolyzes alpha-N-acetylgalactosyl residues from glycolipids and glycoproteins
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?
additional information
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the enzyme plays a dual role in regulating both infectivity and immunosuppression
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?
