3.2.1.48: sucrose alpha-glucosidase
This is an abbreviated version!
For detailed information about sucrose alpha-glucosidase, go to the full flat file.
Word Map on EC 3.2.1.48
-
3.2.1.48
-
border
-
brush
-
lactase
-
enterocytes
-
disaccharidase
-
caco-2
-
mucosal
-
crypt
-
jejunal
-
starch
-
maltase-glucoamylase
-
brush-border
-
glucoamylase
-
maltose
-
lactase-phlorizin
-
ileum
-
trehalase
-
microvillus
-
acarbose
-
basolateral
-
postprandial
-
dipeptidyl
-
villin
-
suckling
-
dipeptidylpeptidase
-
malabsorption
-
goblet
-
3.2.1.20
-
enterocyte-like
-
isomaltose
-
3.4.11.2
-
intestine-specific
-
carbohydrase
-
small-intestinal
-
aminopeptidase-n
-
postconfluent
-
crypt-villus
-
paneth
-
1-deoxynojirimycin
-
bloating
-
dextrin
-
agriculture
-
medicine
- 3.2.1.48
- border
-
brush
- lactase
- enterocytes
- disaccharidase
-
caco-2
- mucosal
-
crypt
- jejunal
- starch
- maltase-glucoamylase
-
brush-border
- glucoamylase
- maltose
-
lactase-phlorizin
- ileum
- trehalase
- microvillus
- acarbose
-
basolateral
-
postprandial
-
dipeptidyl
- villin
-
suckling
-
dipeptidylpeptidase
- malabsorption
-
goblet
-
3.2.1.20
-
enterocyte-like
- isomaltose
-
3.4.11.2
-
intestine-specific
-
carbohydrase
-
small-intestinal
- aminopeptidase-n
-
postconfluent
-
crypt-villus
-
paneth
- 1-deoxynojirimycin
-
bloating
- dextrin
- agriculture
- medicine
Reaction
Synonyms
alpha-glucosidase, glucosidase, sucrose alpha-, intestinal sucrase, isomaltase, More, PF0132, pro-SI, SI, sucrase, sucrase isomaltase, sucrase-invertase, sucrase-isomaltase, sucrase-isomaltase enzyme complex, sucrase/isomaltase, sucrose alpha-glucohydrolase, sucrose hydrolase, SUH
ECTree
3.2.1.48 sucrose alpha-glucosidaseAdvanced search results
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Reference on EC 3.2.1.48 - sucrose alpha-glucosidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Houck, C.M.; Pear, J.R.; Elliott, R.; Perchorowicz, J.T.
Isolation of DNA encoding sucrase genes from Streptococcus salivarius and partial characterization of the enzymes expressed in Escherichia coli
J. Bacteriol.
169
3679-3684
1987
Streptococcus salivarius
Abe, M.; Yamada, K.; Hosoya, N.; Moriuchi, S.
Some properties of luminal sucrase and sucrase-isomaltase complex in rat small intestine
J. Nutr. Sci. Vitaminol.
31
243-252
1985
Rattus rattus
Matsushita, S.
Purification and partial characterization of chick intestinal sucrase
Comp. Biochem. Physiol. B
76
465-470
1983
Gallus gallus
Vasseur, M.; Van Melle, G.; Frangne, R.; Alvarado, F.
Alkali-metal-ion- and H+-dependent activation and/or inhibition of intestinal brush-border sucrase. A model involving three functionally distinct key prototropic groups
Biochem. J.
251
667-675
1988
Oryctolagus cuniculus
Trugnan, G.; Rousset, M.; Zweibaum, A.
Castanospermine: a potent inhibitor of sucrase from the human enterocyte-like cell line Caco-2
FEBS Lett.
195
28-32
1986
Homo sapiens
Vasseur, M.; Tellier, Ch.; Alvarado, F.
Sodium-dependent activation of intestinal brush-border sucrase: correlation with activation by deprotonation from pH 5 to 7
Arch. Biochem. Biophys.
218
263-274
1982
Oryctolagus cuniculus
Montgomery, R.K.; Sybicki, M.A.; Forcier, A.G.; Grand, R.J.
Rat intestinal microvillus membrane sucrase-isomaltase is a single high molecular weight protein and fully active enzyme in the absence of luminal factors
Biochim. Biophys. Acta
661
346-349
1981
Rattus rattus
Hanozet, G.; Pircher, H.P.; Vanni, P.; Oesch, B.; Semenza, G.
An example of enzyme hysteresis. The slow and tight interaction of some fully competitive inhibitors with small intestinal sucrase
J. Biol. Chem.
256
3703-3711
1981
Oryctolagus cuniculus
Conklin, K.A.; Yamashiro, K.M.; Gray, G.M.
Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits
J. Biol. Chem.
250
5735-5741
1975
Homo sapiens
Hauri, H.P.; Quaroni, A.; Isselbacher, K.J.
Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase
Proc. Natl. Acad. Sci. USA
76
5183-5186
1979
Rattus rattus
Sigrist, H.; Ronner, P.; Semenza, G.
A hydrophobic form of the small-intestinal sucrase-isomaltase complex
Biochim. Biophys. Acta
406
433-446
1975
Oryctolagus cuniculus
Sjöström, H.; Noren, O.; Christiansen, L.; Wacker, H.; Semenza, G.
A fully active, two-active-site, single-chain sucrase-isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein
J. Biol. Chem.
255
11332-11338
1980
Sus scrofa
Kolinska, J.; Kraml, J.
Separation and characterization of sucrose-isomaltase and of glucoamylase of rat intestine
Biochim. Biophys. Acta
284
235-247
1972
Rattus rattus
Muto, N.; Nakamura, T.; Yamamoto, I.
Enzymatic formation of a nonreducing L-ascorbic acid alpha-glucoside: purification and properties of alpha-glucosidases catalyzing site-specific transglucosylation from rat small intestine
J. Biochem.
107
222-227
1990
Rattus rattus
Vasseur, M.; Frangne, R.; Cauzac, M.; Mahmood, A.; Alvarado, F.
pH-Dependent inhibitory effects of tris and lithium ion on intestinal brush-border sucrase
J. Enzyme Inhib.
4
15-26
1990
Oryctolagus cuniculus
Galand, G.
First purification and characterization of a sucrase-isomaltase from goose kidney microvillous membrane
Biochim. Biophys. Acta
1033
35-40
1990
Anser anser
Beaulieu, J.F.; Weiser, M.M.; Herrera, L.; Quaroni, A.
Detection and characterization of sucrase-isomaltase in adult human colon and in colonic polyps
Gastroenterology
98
1467-1477
1990
Homo sapiens
Teo, L.H.; Lateef, Z.; Ip, Y.K.
Some properties of the sucrase from the digestive gland of the green mussel Perna viridis L.
Comp. Biochem. Physiol. B
96
47-51
1990
Lissachatina fulica, Arion ater, Perna viridis
-
Sandhu, M.; Mahmood, A.
Kinetic characteristics of soluble and brush border alkaline phosphatase and sucrase activities in developing rat intestine: Effect of hormones
Indian J. Biochem. Biophys.
27
88-92
1990
Rattus rattus
Kapadia, H.A.; Sivakami, S.
Some properties of monkey intestinal sucrase
Indian J. Biochem. Biophys.
27
93-97
1990
Platyrrhini
Fransen, J.A.M.; Hauri, H.P.; Ginsel, L.A.; Naim, H.Y.
Naturally occuring mutations in intestinal sucrase-isomaltase provide evidence for the existence of an intracellular sorting signal in the isomaltase subunit
J. Cell Biol.
115
45-47
1991
Homo sapiens
Quezada-Calvillo, R.; Markowitz, A.J.; Traber, P.G.; Underdown, B.J.
Murine intestinal disaccharidases: identification of structural variants of sucrase-isomaltose complex
Am. J. Physiol.
265
1142-1149
1993
Mus musculus
-
Norman, J.M.; Bunny, K.L.; Giffard, P.M.
Characterization of levJ, a sucrase/fructanase-encoding gene from Actinomyces naeslundii T14V, and comparison of its product with other sucrose-cleaving enzymes
Gene
152
93-98
1995
Actinomyces naeslundii, Actinomyces naeslundii T14V
Kano, T.; Usami, Y.; Adachi, T.; Tatematsu, M.; Hirano, K.
Inhibition of purified human sucrase and isomaltase by ethanolamine derivatives
Biol. Pharm. Bull.
19
341-344
1996
Homo sapiens
Holt, S.M.; Cote, G.L.
Cloning and characterization of a sucrase from Leuconostoc mesenteroides
Biotechnol. Lett.
19
903-907
1997
Leuconostoc mesenteroides
-
Schönert, S.; Buder, T.; Dahl, M.K.
Identification and enzymatic characterization of the maltose-inducible alpha-glucosidase MalL (sucrase-isomaltase-maltase) of Bacillus subtilis
J. Bacteriol.
180
2574-2578
1998
Bacillus subtilis
Hertel, S.; Heinz, F.; Vogel, M.
Hydrolysis of low-molecular-weight oligosaccharides and oligosaccharide alditols by pig intestinal sucrase/isomaltase and glucosidase/maltase
Carbohydr. Res.
326
264-276
2000
Sus scrofa
Mukherjee, S.; Khowala, S.
Regulation of cellobiase secretion in Termitomyces clypeatus by co-aggregation with sucrase
Curr. Microbiol.
45
70-73
2002
Termitomyces clypeatus
Finn, A.L.; Kuzhikandathil, E.V.; Oxford, G.S.; Itoh-Lindstrom, Y.
Sucrase-isomaltase is an adenosine 3',5'-cyclic monophosphate-dependent epithelial chloride channel
Gastroenterology
120
117-125
2001
Necturus maculosus
Kaur, N.; Kaur, J.; Mahmood, A.
Effect of harmaline on rat intestinal brush border sucrase activity
INDIAN J. Biochem. Biophys.
39
119-123
2002
Rattus norvegicus
Kim, H.S.; Park, H.J.; Heu, S.; Jung, J.
Molecular and functional characterization of a unique sucrose hydrolase from Xanthomonas axonopodis pv. glycines
J. Bacteriol.
186
411-418
2004
Xanthomonas axonopodis (Q6UVM5), Xanthomonas axonopodis
Jacob, R.; Purschel, B.; Naim, H.Y.
Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex
J. Biol. Chem.
277
32141-32148
2002
Homo sapiens
Proepsting, M.J.; Jacob, R.; Naim, H.Y.
A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi
J. Biol. Chem.
278
16310-16314
2003
Homo sapiens
Petersen, Y.M.; Elnif, J.; Schmidt, M.; Sangild, P.T.
Glucagon-like peptide 2 enhances maltase-glucoamylase and sucrase-isomaltase gene expression and activity in parenterally fed premature neonatal piglets
Pediatr. Res.
52
498-503
2002
Sus scrofa
Gu, N.; Suzuki, N.; Takeda, J.; Adachi, T.; Tsujimoto, G.; Aoki, N.; Ishihara, A.; Tsuda, K.; Yasuda, K.
Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase in Caco-2 cells
Biochem. Biophys. Res. Commun.
325
308-313
2004
Homo sapiens
Martin-Latil, S.; Cotte-Laffitte, J.; Beau, I.; Quero, A.M.; Geniteau-Legendre, M.; Servin, A.L.
A cyclic AMP protein kinase A-dependent mechanism by which rotavirus impairs the expression and enzyme activity of brush border-associated sucrase-isomaltase in differentiated intestinal Caco-2 cells
Cell. Microbiol.
6
719-731
2004
Homo sapiens
Zheng, Y.; Shentu, X.; Shen, Y.
Inhibition of porcine small intestinal sucrase by valienamine
Chin. J. Chem. Engin.
13
429-432
2005
Sus scrofa
-
Adeola, O.; King, D.E.
Developmental changes in morphometry of the small intestine and jejunal sucrase activity during the first nine weeks of postnatal growth in pigs
J. Anim. Sci.
84
112-118
2006
Sus scrofa
Proepsting, M.J.; Kanapin, H.; Jacob, R.; Naim, H.Y.
A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum
J. Cell Sci.
118
2775-2784
2005
Homo sapiens
Karley, A.J.; Ashford, D.A.; Minto, L.M.; Pritchard, J.; Douglas, A.E.
Significance of gut sucrase activity for osmoregulation in the pea aphid Acyrthosiphon pisum
J. Insect Physiol.
51
1313-1319
2005
Acyrthosiphon pisum
Gu, N.; Adachi, T.; Takeda, J.; Aoki, N.; Tsujimoto, G.; Ishihara, A.; Tsuda, K.; Yasuda, K.
Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells
J. Nutr. Sci. Vitaminol.
52
105-112
2006
Homo sapiens
Gu, N.; Adachi, T.; Matsunaga, T.; Tsujimoto, G.; Ishihara, A.; Yasuda, K.; Tsuda, K.
HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells
Biochem. Biophys. Res. Commun.
353
617-622
2007
Homo sapiens
Honma, K.; Mochizuki, K.; Goda, T.
Carbohydrate/fat ratio in the diet alters histone acetylation on the sucrase-isomaltase gene and its expression in mouse small intestine
Biochem. Biophys. Res. Commun.
357
1124-1129
2007
Mus musculus
Suzuki, T.; Mochizuki, K.; Goda, T.
Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats
Biochem. Biophys. Res. Commun.
369
788-793
2008
Rattus norvegicus
Naumoff, D.G.
Structure and evolution of the mammalian maltase-glucoamylase and sucrase-isomaltase genes
Mol. Biol.
41
962-973
2007
Homo sapiens (P14410)
-
Kim, M.I.; Kim, H.S.; Jung, J.; Rhee, S.
Crystal structures and mutagenesis of sucrose hydrolase from Xanthomonas axonopodis pv. glycines: insight into the exclusively hydrolytic amylosucrase fold
J. Mol. Biol.
380
636-647
2008
Xanthomonas axonopodis (Q6UVM5)
Kim, K.Y.; Nam, K.A.; Kurihara, H.; Kim, S.M.
Potent alpha-glucosidase inhibitors purified from the red alga Grateloupia elliptica
Phytochemistry
69
2820-2825
2008
Rattus norvegicus
Alfalah, M.; Keiser, M.; Leeb, T.; Zimmer, K.P.; Naim, H.Y.
Compound heterozygous mutations affect protein folding and function in patients with congenital sucrase-isomaltase deficiency
Gastroenterology
136
883-892
2009
Homo sapiens
Wetzel, G.; Heine, M.; Rohwedder, A.; Naim, H.Y.
Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase
Biol. Chem.
390
545-549
2009
Homo sapiens
Sim, L.; Willemsma, C.; Mohan, S.; Naim, H.Y.; Pinto, B.M.; Rose, D.R.
Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains
J. Biol. Chem.
285
17763-17770
2010
Homo sapiens (P14410), Homo sapiens
Champion, E.; Remaud-Simeon, M.; Skov, L.K.; Kastrup, J.S.; Gajhede, M.; Mirza, O.
The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove
Acta Crystallogr. Sect. D
65
1309-1314
2009
Xanthomonas campestris pv. campestris
Gupta, S.; Mahmood, S.; Khan, R.H.; Mahmood, A.
Inhibition of brush border sucrase by polyphenols in mouse intestine
Biosci. Rep.
30
111-117
2010
Mus musculus
Minai-Tehrani, D.; Fooladi, N.; Minoui, S.; Sobhani-Damavandifar, Z.; Aavani, T.; Heydarzadeh, S.; Attar, F.; Ghaffari, M.; Nazem, H.
Structural changes and inhibition of sucrase after binding of scopolamine
Eur. J. Pharmacol.
635
23-26
2010
Saccharomyces cerevisiae, Homo sapiens
Singh, A.; Mandal, D.
A novel sucrose/H+ symport system and an intracellular sucrase in Leishmania donovani
Int. J. Parasitol.
41
817-826
2011
Leishmania donovani, Leishmania donovani MHOM/IN/1978/UR6
Lee, S.H.; Yu, S.Y.; Nakayama, J.; Khoo, K.H.; Stone, E.L.; Fukuda, M.N.; Marth, J.D.; Fukuda, M.
Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation
J. Biol. Chem.
285
37683-37692
2010
Homo sapiens, Mus musculus
Comfort, D.A.; Chou, C.J.; Conners, S.B.; VanFossen, A.L.; Kelly, R.M.
Functional-genomics-based identification and characterization of open reading frames encoding alpha-glucoside-processing enzymes in the hyperthermophilic archaeon Pyrococcus furiosus
Appl. Environ. Microbiol.
74
1281-1283
2008
Pyrococcus furiosus (Q8U4F6), Pyrococcus furiosus
Henstroem, M.; Diekmann, L.; Bonfiglio, F.; Hadizadeh, F.; Kuech, E.M.; von Koeckritz-Blickwede, M.; Thingholm, L.B.; Zheng, T.; Assadi, G.; Dierks, C.; Heine, M.; Philipp, U.; Distl, O.; Money, M.E.; Belheouane, M.; Heinsen, F.A.; Rafter, J.; Nardone, G.; Cuomo, R.; Usai-Satta, P.; Galeazzi, F.; Ne, N.e.r.
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
Gut
67
263-270
2018
Homo sapiens (P14410), Homo sapiens
Simsek, M.; Quezada-Calvillo, R.; Ferruzzi, M.G.; Nichols, B.L.; Hamaker, B.R.
Dietary phenolic compounds selectively inhibit the individual subunits of maltase-glucoamylase and sucrase-isomaltase with the potential of modulating glucose release
J. Agric. Food Chem.
63
3873-3879
2015
Mus musculus (B5THE3), Mus musculus, Homo sapiens (P14410), Homo sapiens
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