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3.2.1.31: beta-glucuronidase

This is an abbreviated version!
For detailed information about beta-glucuronidase, go to the full flat file.

Word Map on EC 3.2.1.31

Reaction

a beta-D-glucuronoside
+
H2O
=
D-glucuronate
+
an alcohol

Synonyms

beta-D-glucuronidase, Beta-D-glucuronoside glucuronosohydrolase, Beta-G1, beta-Gluc, beta-glucuronidase, beta-glucuronidase A, betaG, BLG, exo-beta-D-glucuronidase, exo-beta-glucuronidase, GlcAase, glucuronidase, beta-glucuronide glucuronohydrolase, GUR, GUS, Gus2, GusA, GusB, hGUSB, ketodase, More, PGUS, TM1062, TmGUSI, UidA

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.31 beta-glucuronidase

Inhibitors

Inhibitors on EC 3.2.1.31 - beta-glucuronidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)bis(4,4,4-triethoxybut-2-en-1-one)
-
-
1,4-D-glucarolactone
2-deoxy-2-fluoro-beta-D-glucosyluronic acid fluoride
4-chloromercuriphenylsulfonic acid
-
inhibition of isozymes I and II
Al3+
DQ459484
10 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
ascorbic acid
azide
Ca2+
DQ459484
recombinant enzyme expressed in Escherichia coli is slightly inhibited
CaCl2
-
2 mM, 14.8% inhibition
Citric acid
Cr3+
DQ459484
10 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
D-glucaric acid 1,4-lactone
-
5 mM, 30% inhibition
D-glucaro-1,4-lactone
-
-
D-glucuronate
-
IC50: 7.5 mM, competitive
D-saccharic acid 1,4-lactone
D-saccharic acid 1,4-lactone monohydrate
-
a betaG-specific inhibitor
D-saccharic acid-1,4-lactone
-
-
delta-D-glucuronolactone
-
-
dithiothreitol
DQ459484
1%, 22% inhibition
estradiol 3-glucuronide
-
-
Fe2+
DQ459484
1 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
Fe3+
DQ459484
10 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
FeCl2
-
2 mM,33.1% inhibition
fucoxanthin
glucuronic acid
glycyrrhizin
heparin
inhibitor
-
methanol
-
-
MgCl2
-
2 mM, 24.8% inhibition
Mn2+
DQ459484
1 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
MnCl2
-
2 mM, 31.9% inhibition
NaCl
-
between 0.075 and 0.25 M, the activity is decreased with increasing NaCl concentration. Above 0.25 M, the enzyme shows no activity. The activity of beta-glucuronidase acting on p-nitrophenyl-beta-D-glucuronide is decreased with increasing NaCl concentrations, and 0.4 M NaCl produces 50% inhibition
NEM
-
IC50: 0.09 mM
NiCl2
-
2 mM, 52% inhibition
p-chloromercuribenzoate
-
-
p-chloromercuriphenylsulfonic acid
-
IC50: 0.04 mM
p-nitrophenol
-
IC50: 0.3 mM, competitive
paracetamol glucuronide
-
-
Pb2+
DQ459484
10 mM, recombinant enzyme expressed in Escherichia coli is completely inhibited
Phenolic and alcoholic glucuronides
-
-
-
Potassium saccharate
-
-
S-saccharic acid 1,4-lactone
-
inhibits enzyme in several patients with colon cancer in addition to the healthy controls
saccharic acid 1,4-lactone
saccharo-1,4-lactone
saccharolactone
-
SDS
DQ459484
0.1% v/v, complete inhibition
silybin
-
IC50: 1 mM, non-competitive
sodium desoxycholate
-
-
TLCK
-
IC50: 0.3 mM
Urea
DQ459484
1%, 38% inhibition
additional information
-