3.2.1.31: beta-glucuronidase
This is an abbreviated version!
For detailed information about beta-glucuronidase, go to the full flat file.
Word Map on EC 3.2.1.31
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3.2.1.31
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lysosomal
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urine
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urinary
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neutrophil
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bile
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leukocyte
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granule
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lysozyme
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polymorphonuclear
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hydrolases
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protoplasts
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mucopolysaccharidosis
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agrobacterium
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cathepsins
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cytochemical
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biliary
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tumefaciens
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cauliflower
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n-acetyl-beta-d-glucosaminidase
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beta-n-acetylglucosaminidase
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alpha-mannosidase
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degranulation
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glycosaminoglycans
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sulfatase
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glucuronic
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azurophilic
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beta-hexosaminidase
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nitroreductase
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nptii
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hygromycin
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zymosan
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alpha-galactosidase
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bombard
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calli
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glycosidases
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agrobacterium-mediated
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deconjugation
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neomycin
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unconjugated
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beta-d-galactosidase
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arylsulphatase
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fmlp
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diagnostics
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alpha-l-fucosidase
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synthesis
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coliforms
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medicine
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biotechnology
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alpha-naphthyl
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toxicology
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pomatia
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analysis
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hexosaminidase
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crevicular
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1,2-dimethylhydrazine
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drug development
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nutrition
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molecular biology
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alpha-l-iduronidase
- 3.2.1.31
- lysosomal
- urine
- urinary
- neutrophil
- bile
- leukocyte
- granule
- lysozyme
-
polymorphonuclear
- hydrolases
-
protoplasts
- mucopolysaccharidosis
- agrobacterium
- cathepsins
-
cytochemical
- biliary
- tumefaciens
- cauliflower
-
n-acetyl-beta-d-glucosaminidase
- beta-n-acetylglucosaminidase
- alpha-mannosidase
-
degranulation
- glycosaminoglycans
-
sulfatase
-
glucuronic
-
azurophilic
- beta-hexosaminidase
- nitroreductase
- nptii
- hygromycin
- zymosan
- alpha-galactosidase
-
bombard
-
calli
- glycosidases
-
agrobacterium-mediated
-
deconjugation
- neomycin
-
unconjugated
- beta-d-galactosidase
- arylsulphatase
- fmlp
- diagnostics
- alpha-l-fucosidase
- synthesis
-
coliforms
- medicine
- biotechnology
-
alpha-naphthyl
- toxicology
- pomatia
- analysis
- hexosaminidase
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crevicular
- 1,2-dimethylhydrazine
- drug development
- nutrition
- molecular biology
- alpha-l-iduronidase
Reaction
Synonyms
beta-D-glucuronidase, Beta-D-glucuronoside glucuronosohydrolase, Beta-G1, beta-Gluc, beta-glucuronidase, beta-glucuronidase A, betaG, BLG, exo-beta-D-glucuronidase, exo-beta-glucuronidase, GlcAase, glucuronidase, beta-glucuronide glucuronohydrolase, GUR, GUS, Gus2, GusA, GusB, hGUSB, ketodase, More, PGUS, TM1062, TmGUSI, UidA
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Application
Application on EC 3.2.1.31 - beta-glucuronidase
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analysis
biotechnology
diagnostics
drug development
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stable expression of GusA in Gardia lamblia strain WB C6 for establishing a system to test enzyme susceptibility to the anti-giardial drugs nitazoxanide and metronidazole, overview
medicine
molecular biology
nutrition
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crossover feeding trial in healthy women and men with a diet high in selected citrus fruit, crucifers and soy and a diet devoid of fruits, vegetables, and soy. Participants of the fruit and soy diet display a signifcantly higher beta-glucuronidase activity than those with the basal diet, where the enzyme activity decreased during the diet. Response to the diet does not differ by sex
synthesis
toxicology
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assay for beta-glucuronidase is able to distinguish Escherichia coli from other Escherichia species
analysis
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enzymatic assay adapted to study the fate of fecal coliforms in survival experiments, and appears to be rapid and efficient way to estimate the microbiological quality of surface waters. The major advantage of the enzymtic assay is the very short time response, and thus this method offers a powerful, rapid, and efficient way to estimate the microbiological quality of bathing and fishing areas, and to monitor disinfection efficiencies
analysis
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reporter enzyme which is used for studies in higher plants because endogenous activities are low and sensitive assays are available. A version of GUS with phenylalanine at the mature N-terminus accumulates a minimum of 3fold lower than GUS with methionine at its mature N-terminus. This altered protein can be useful for promoter studies which require more rapid changes in the accumulation of the reporter protein
analysis
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the enzyme is useful in analysis of phytoestrogens and related compounds in human biofluids, e.g. urine
analysis
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comparison of commercially available kits to assess water quality and evaluation of their ability to detect Escherichia coli. Chromocult, MI agar, Readycult, and Colilert detect beta-glucuronidase production from respectively 79.9, 79.9, 81.1, and 51.4% of the 74 Escherichia coli strains tested. These four methods detect beta-galactosidase production from respectively 85.1, 73.8, 84.1, and 84.1% of the total coliform strains tested. The high level of false-negative results for Escherichia coli recognition obtained by all four methods suggests that they may not be appropriate for identification of presumptive Escherichia coli strains
analysis
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comparison of commercially available kits used for the simultaneous detection of coliforms and Escherichia coli from water. Membrane lactose glucuronide agar, Colilert-18, MI agar, Colitag and Chromocult agar to detect beta-D-glucuronidase activity are tested with over 1000 isolates of Escherichia coli recovered from naturally contaminated water samples. Four of the media give very similar results but membrane lactose glucuronide agar fails to detect glucuronidase activity in 15.6% of the cultures tested
analysis
in environmental toxicology, techniques used to visualise lysosomes in order to determine their responses to pollutants are the lysosomal structural changes test and the lysosomal membrane stability test are based on the histochemical application of lysosomal marker enzymes. In mussel digestive cells, the marker enzymes used are beta-glucuronidase and hexosaminidase. beta-Glucuronidase, but not hexosaminindase, histochemistry provides an appropriate marker for the lysosomal structural changes test and that, although both lysosomal marker enzymes can be employed in the lysosomal membrane stability test, different values would be obtained depending on the marker enzyme employed
analysis
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precise and reliable detection of Escherichia coli strains for differentiation from biochemically and ohylogenetically related bacteria. Method is based on polymerase chain reaction, in which four genes coding for lactose permease, cytochrome bd complex, beta-D-glucuronidase, and beta-D-galactosidase, serve as target DNA sequences
analysis
Sulfolobus gene can be used as reporter in any thermophilic microorganism lacking an endogenous beta-glucuronidase activity
analysis
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construction of a noncompetitive homogeneous biosensor system for immunodetection of small molecules based on beta-glucuronidase complementation
analysis
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Sulfolobus gene can be used as reporter in any thermophilic microorganism lacking an endogenous beta-glucuronidase activity
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comparison of Escherichia coli and Staphylococcus sp. RLH1 beta-glucuronidase as gene fusion markers in plant transformation experiments. The Staphylococcus enzyme shows higher catalytic activity and increased accessible surface area of active site residues compared with the Escherichia coli protein
biotechnology
comparison of Escherichia coli and Staphylococcus sp. RLH1 beta-glucuronidase as gene fusion markers in plant transformation experiments. The Staphylococcus enzyme shows higher catalytic activity and increased accessible surface area of active site residues compared with the Escherichia coli protein
biotechnology
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comparison of Escherichia coli and Staphylococcus sp. RLH1 beta-glucuronidase as gene fusion markers in plant transformation experiments. The Staphylococcus enzyme shows higher catalytic activity and increased accessible surface area of active site residues compared with the Escherichia coli protein
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the enzyme is useful in analysis of phytoestrogens and related compounds in human biofluids, e.g. urine
diagnostics
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beta-glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure, e.g. plasma BG activity for low-level organophosphorus-exposure compared to BChE activity, overview
diagnostics
a technique for MPS VII diagnosis is adapted for smaller amounts of sample and reagents. That will facilitate the use of smaller amounts of samples, which may be used for other techniques and to save material. Given the importance of early MPS VII diagnosis due to the severity of the disease, using reliable diagnostic techniques in dried blood spots is essential
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a high varability in the expression of beta-Glc in human liver and kidney. Therefore cleavage of drug glucuronides that accumulate during chronic therapy or are used as prodrugs can show a wide interindividual variability in humans, which might result in variable response to drugs
medicine
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the potent beta-glucuronidase activity caused by the glucuronic acid conjugates from xenobiotics and endogenous compounds is a prime factor in the etiology of colon cancer
medicine
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when beta-glucuronidase producing bacteria infect the bile, the pH of the bile becomes raised, the high pH and bile induce the enzyme, and then bilirubin gallstones can be easily formed
medicine
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after liver injury induced by ontraperitoneal injections of N-nitrosodimethylamine, a significant increase is observed in beta-glucuronidase levels in the serum, liver homogenate, and subcellular fractions, but not in the nuclear fraction, concomitant with a maximum lysosomal fragility on day 21 during the induced fibrosis
medicine
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measurement of beta-glucuronidase activity has no additive clinical value following a parathion overdose in humans
medicine
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bronchoalveolar lavage fluid of children with culture-positive bacterial inflammation displays a significant increase of beta-glucuronidase activity. beta-Glucuronidase activity shows superior predictive ability for bacterial lung infection than other markers of inflammation
medicine
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when beta-glucuronidase producing bacteria infect the bile, the pH of the bile becomes raised, the high pH and bile induce the enzyme, and then bilirubin gallstones can be easily formed
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stable expression of GusA in Gardia lamblia strain WB C6 for establishing a system to test enzyme susceptibility to the anti-giardial drugs nitazoxanide and metronidazole, overview
molecular biology
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beta-glucuronidase is the most frequent reporter gene in plants. Beta-glucuronidase enzyme activity is not only tissue-specific but also genotype-dependent
molecular biology
DQ459484
use of beta-glucuronidase from Thermotoga maritima as a thermostable marker in higher plants, reporter enzyme in plant genetic research
the enzyme appears suitable for use in enzymatic oligosaccharide synthesis in either the transglycosylation mode or by use of glycosynthase and thioglycoligase approaches
synthesis
mutant enzyme A365H/R563E has great potential in the industrial production of glycyrrhetinic acid 3-O-mono-beta-D-glucuronide
synthesis
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the enzyme appears suitable for use in enzymatic oligosaccharide synthesis in either the transglycosylation mode or by use of glycosynthase and thioglycoligase approaches
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synthesis
Aspergillus oryzae Li-3
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mutant enzyme A365H/R563E has great potential in the industrial production of glycyrrhetinic acid 3-O-mono-beta-D-glucuronide
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in environmental toxicology, techniques used to visualise lysosomes in order to determine their responses to pollutants are the lysosomal structural changes test and the lysosomal membrane stability test are based on the histochemical application of lysosomal marker enzymes. In mussel digestive cells, the marker enzymes used are beta-glucuronidase and hexosaminidase. beta-Glucuronidase, but not hexosaminindase, histochemistry provides an appropriate marker for the lysosomal structural changes test and that, although both lysosomal marker enzymes can be employed in the lysosomal membrane stability test, different values would be obtained depending on the marker enzyme employed
toxicology
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measurement of beta-glucuronidase activity has no additive clinical value following a parathion overdose in humans