3.2.1.18: exo-alpha-sialidase

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For detailed information about exo-alpha-sialidase, go to the full flat file.

Reaction

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.18 exo-alpha-sialidase

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Results	in table
31	Activating Compound
107956	AA Sequence
30	Application
1	CAS Registry Number
68	Cloned(Commentary)
26	Crystallization (Commentary)
20027	Disease/ Diagnostics
3	Expression
33	General Information
15	General Stability
387	IC50 Value
688	Inhibitors
29	kcat/KM [mM/s]
94	Ki Value [mM]
223	KM Value [mM]
107	Localization
87	Metals/Ions
95	Molecular Weight [Da]
65	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
450	Organism
3	Pathway
605	PDB ID
114	pH Optimum
26	pH Range
6	pH Stability
1	pI Value
31	Posttranslational Modification
221	Protein Variants
101	Purification (Commentary)
24	Reaction
1	Reaction Type
387	Reference
128	Source Tissue
69	Specific Activity [micromol/min/mg]
31	Storage Stability
755	Substrates and Products (Substrate)
86	Subunits
437	Synonyms
1	Systematic Name
63	Temperature Optimum [°C]
10	Temperature Range [°C]
22	Temperature Stability [°C]
36	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.2.1.18 - exo-alpha-sialidase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0

Bos taurus

-

6 h, 20% loss in activity

171156

0 - 25

2 entries

20 - 40

Bacteroides fragilis

Q5L868

the enzyme remains stable after 1 h at 20-40°C

749667

25 - 65

Trypanosoma rangeli

-

engineered free sialidase Tr6 is stable at 25°C for at least 24 h. At 45°C the enzyme is stable for at least 100 min. 2% of the initial trans-sialidase activity is retained after 5 min of incubation at 65°C

729658

37

Pseudomonas aeruginosa

-

24 h stable

171138

4

Homo sapiens

-

24 h, 50% loss of activity

665540

40

Bifidobacterium bifidum

-

the enzyme is stable at temperatures less than 40°C

750104

45

Homo sapiens

-

5 min, 60% loss in activity

171181

49

Glutamicibacter nicotianae

-

Tm-value, sialidase isoenzyme NA2

665425

50

7 entries

51

Glutamicibacter nicotianae

-

Tm-value, sialidase isoenzyme NA1

665425

52

Homo sapiens

-

inactivated

171144

56

2 entries

60

Sus scrofa

-

after 30 min nearly complete loss in activity

171157

0 - 25

influenza A virus

-

the enzyme is stable at 4 and 25°C for 24 h. At 37°C, the activity is retained for at least 7 h in the monovalent bulks, but by 24 h it has about 50% of its original activity. Three freeze-thaw cycles lead to a loss of about 70% of enzyme activity

731014

0 - 25

influenza A virus

-

the enzyme is stable at 4 and 25°C for 24 h. At 37°C, the activity is retained for at least 7 h in the monovalent bulks, but by 24 h it has about 75% of its original activity. Three freeze-thaw cycles lead to a loss of about 20% of enzyme activity

731014

50

Clostridium perfringens

-

the NanI sialidase shows no loss of activity after a 10 min incubation at 50°C in Tris-HCl buffer, pH 7.2

729041

50

Glutamicibacter nicotianae

-

30 min, about 30% loss of activity of sialidase isoenzyme NA1

665425

50

Glutamicibacter nicotianae

-

30 min, about 30% loss of activity of sialidase isoenzyme NA2

665425

50

Homo sapiens

-

30 min, complete inactivation

171121

50

Streptococcus sp.

-

-

171150

50

Streptococcus sp.

-

after 10 min inactivated

171143

50

unidentified influenza virus

-

inactive

171119

56

influenza A virus

-

inactivation

655754

56

Pseudomonas aeruginosa

-

after 30 min 80% loss in activity

171138