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3.2.1.18: exo-alpha-sialidase

This is an abbreviated version!
For detailed information about exo-alpha-sialidase, go to the full flat file.

Word Map on EC 3.2.1.18

Reaction

colominic acid
+
H2O
=
sialic acid
 +
lactose

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.18 exo-alpha-sialidase

Specific Activity

Specific Activity on EC 3.2.1.18 - exo-alpha-sialidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00012
-
purified recombinant enzyme, substrate 4-methylumbelliferyl D-N-acetylneuraminyl-alpha-(2->3)-D-galactopyranoside, pH 3.5, 37°C
0.0005
-
leukocytes
0.0014
-
-
0.0024
-
liver
0.00495
-
with 4-nitrophenyl acetate as substrate, at pH 5.0 and 37°C
0.014
-
-
0.04
-
-
0.0409
-
purified recombinant enzyme, substrate 4-methylumbelliferyl alpha-D-N-acetylneuraminic acid, pH 3.5, 37°C
0.11
-
-
0.12
-
-
0.123
-
purified recombinant mutant
0.999
-
purified recombinant enzyme
1.03
-
A99, small sialidase
1.9
purified recombinant enzyme
100.9
with sialyl-alpha-2,6-lactose as substrate, pH 7.0 and 37°C
11.58
-
purified enzyme, substrate 2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid
165
-
intralysosomal
17.2
-
purified enzyme
174
-
purified enzyme
18.2
with alpha1-acid glycoprotein as substrate, pH 7.0 and 37°C
2.13
-
purified enzyme, substrate alpha-(2-3)-sialyllactose
2860
Macrobdella sp.
-
-
314
-
recombinant head domain, pH 6.5, 37°C
35
with fetuin as substrate, pH 7.0 and 37°C
37
-
neuraminidase I
378
-
wild-type, pH 6.5, 37°C
390
-
A99, large sialidase
4.05
-
purified enzyme
570
-
DSM 756, large sialidase
59.4
-
-
615
-
sialyllactose as substrate
63.6
-
neuraminidase II
64.1
with colominic acid as substrate, pH 7.0 and 37°C
740
-
A99, small sialidase, cloned
8.6
with transferrin as substrate, pH 7.0 and 37°C
97.7
with sialyl-alpha-2,3-lactose as substrate, pH 7.0 and 37°C
additional information