3.2.1.18: exo-alpha-sialidase
This is an abbreviated version!
For detailed information about exo-alpha-sialidase, go to the full flat file.
Word Map on EC 3.2.1.18
-
3.2.1.18
-
influenza
-
sialic
-
viruses
-
vaccine
-
pandemic
-
oseltamivir
-
lectin
-
sialylated
-
oligosaccharide
-
subtype
-
epitope
-
erythrocyte
-
gangliosides
-
lymphocyte
-
reassortant
-
hemagglutination
-
anti-influenza
-
chicken
-
glycans
-
surveillance
-
galactose
-
cholera
-
desialylation
-
hn
-
glycoconjugates
-
outbreak
-
cruzi
-
poultry
-
virion
-
bird
-
pronase
-
parainfluenza
-
epidemic
-
n-acetylneuraminic
-
trypanosoma
-
peanut
-
mucin
-
n-linked
-
newcastle
-
agglutination
-
perfringens
-
nucleoprotein
-
prophylaxis
-
concanavalin
-
medicine
-
drift
-
sendai
-
analysis
-
n-acetylgalactosamine
-
ferret
-
nutrition
-
endoglycosidase
-
molecular biology
-
diagnostics
-
gm3
- 3.2.1.18
- influenza
-
sialic
- viruses
- vaccine
- pandemic
- oseltamivir
- lectin
-
sialylated
- oligosaccharide
- subtype
- epitope
- erythrocyte
- gangliosides
- lymphocyte
-
reassortant
-
hemagglutination
-
anti-influenza
- chicken
- glycans
-
surveillance
- galactose
- cholera
-
desialylation
- hn
- glycoconjugates
-
outbreak
- cruzi
-
poultry
- virion
- bird
- pronase
- parainfluenza
-
epidemic
-
n-acetylneuraminic
- trypanosoma
- peanut
- mucin
-
n-linked
- newcastle
-
agglutination
- perfringens
- nucleoprotein
-
prophylaxis
-
concanavalin
- medicine
-
drift
-
sendai
- analysis
- n-acetylgalactosamine
- ferret
- nutrition
-
endoglycosidase
- molecular biology
- diagnostics
- gm3
Reaction
Synonyms
acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA
ECTree
3.2.1.18 exo-alpha-sialidaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.2.1.18 - exo-alpha-sialidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
-
isoform Neu3 plays a key role in skeletal muscle differentiation by strictly modulating the ganglioside content of adjacent cells, with special regard to GM3
-
myoblast cell. Isoform Neu2 mRNA and enzymatic activity are significantly increased in hypertrophic myofibers. Constitutive activation of AKT or Igf-1 treatment as well as treatment with vasopressin or trichostatin results in rise in Neu2 activity. Myofiber atrophy obtained by dexamethasone treatment or starvation triggers a significant loss of Neu2 activity and is paralleled by downregulation of Neu2 transcript levels
-
plasma membrane ganglioside sialidase asymmetrically accumulates at the tip of one neurite of the unpolarized rat neuron, inducing actin instability
additional information
-
the organism is unable to use either sialic acid or colominic acid as a sole source of carbon
-
the organism is unable to use either sialic acid or colominic acid as a sole source of carbon
-
-
expressing human tyrosinase under the transcriptional control of the T-RExTM. The expression level of Neu4L is dramatically decreased prior to apoptosis. Neu4L and its substrate ganglioside GD3 may act as key molecules in the mitochondrial apoptotic pathway in neuronal cells
only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activation of lymphocytes by exposure to anti-CD3 and anti-CD28 IgG results in a ninefold increase in Neu1-specific activity after growth of cells in culture for 5 days. The increase in Neu1 enzyme activity correlates with increased synthesis of Neu1-specific mRNA. Neu1 is present on the surface of freshly isolated and activated CD4 and CD8 T lymphocytes. Cell surface Neu1 is tightly associated with a subunit of protective protein/cathepsin A. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma
only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activity of Neu3 changes minimally in activated lymphocytes. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma
additional information
-
tissue distribution of the 3 isozymes, Neu-1 is ubiquitously expressed at higher level, except for neutrophils
additional information
-
tissue distribution of the 3 isozymes, Neu-1 is ubiquitously expressed at higher level, except for skeletal muscle
