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3.2.1.18: exo-alpha-sialidase

This is an abbreviated version!
For detailed information about exo-alpha-sialidase, go to the full flat file.

Word Map on EC 3.2.1.18

Reaction

colominic acid
+
H2O
=
sialic acid
+
lactose

Synonyms

acetylneuraminidase, Acetylneuraminyl hydrolase, acid sialidase, acylneuraminyl glycohydrolase, alpha-N-acylneuraminate glycohydrolase, alpha-neuraminidase, alpha-sialidase, alpha2,6-sialidase, alpha2,6-sialyltransferase, alpha2,6-trans-sialidase, Am0705, Am0707, Am1757, Am2085, Cytosolic sialidase, DELTA15Pd2,6ST, endo-N, endo-N-acylneuraminidase, endo-sialidase, endoNF, endosialidase, exo-alpha-sialidase, exo-sialidase, G9 sialidase, Ganglioside sialidase, ganglioside-specific sialidase, GH33C, glycosyl hydrolase, haemagglutinin-neuraminidase protein, hemagglutinin-neuraminidase, hemagglutinin-neuraminidase glycoprotein, HN, HsNEU2, IID sialidase, KDNase, Lysosomal sialidase, Major 85 kDa surface antigen, Major surface antigen, Membrane sialidase, MmNEU3, More, Mouse skeletal muscle sialidase, MSS, MTS, mucopolysaccharide N-acetylneuraminylhydrolase, Murine thymic sialidase, N-acetyl-alpha-neuraminidase, N-acetyl-alpha-neuraminidase 1, N-acetyl-alpha-neuraminidase 2, N-acetyl-alpha-neuraminidase 3, N-acetyl-alpha-neuraminidase 4, N-acetylneuraminosyl glycohydrolase, N-acylneuraminate glycohydrolase, N-acylneuraminosyl glycohydrolase, NA, NA1, NA2, NAN1, NanA, NANase, NanB, NanC, NanH, NanI, NanICD, NanJ, NanPs, Neu, NEU1, NEU2, Neu3, Neu3a, Neu3d, Neu3e, NEU4, NEU4 long, NEU4 short, NEU4L, Neu4L sialidase, neuramindase, neuraminidase, neuraminidase 1, neuraminidase 2, neuraminidase 3, neuraminidase-1, PA2794, SA85-1.1 protein, SA85-1.2 protein, SA85-1.3 protein, SiaBb1, sialidase, sialidase 4, sialidase II, sialidase Neu2, sialidase-2, sialidase-3, sialidase-4, sialidase/neuraminidase mutant F129A, sialyl hydrolase, STNA, TcTS, TDE0471, Tr6, trans-sialidase, trans-sialidase 1, TSia, VCNA

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
                3.2.1.18 exo-alpha-sialidase

IC50 Value

IC50 Value on EC 3.2.1.18 - exo-alpha-sialidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.058
(2R,3R,4S)-3-(acetylamino)-2-[(1S,2S)-3-(acetylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
Homo sapiens
-
0.013
(2R,3R,4S)-3-(acetylamino)-2-[(1S,2S)-3-(benzoylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
Homo sapiens
-
0.032
(2R,3R,4S)-3-(acetylamino)-2-[(1S,2S)-3-(butyrylamino)-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
Homo sapiens
-
0.68
(2R,3R,4S)-3-(acetylamino)-2-[(1S,2S)-3-[(cyclopropylcarbonyl)amino]-1,2-dihydroxypropyl]-4-hydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
Homo sapiens
-
0.12
(3E)-3-(1,3-benzothiazol-2-yl)-4-(2,5-dimethylphenyl)but-3-enoate
Trypanosoma cruzi
-
-
0.16
(3E)-3-(1,3-benzothiazol-2-yl)-4-(2-ethoxyphenyl)but-3-enoate
Trypanosoma cruzi
-
-
0.18
(3E)-3-(1,3-benzothiazol-2-yl)-4-(3,4-dimethoxyphenyl)but-3-enoate
Trypanosoma cruzi
-
-
0.12
(3E)-3-(1,3-benzothiazol-2-yl)-4-(3-fluorophenyl)but-3-enoate
Trypanosoma cruzi
-
-
0.15
(3E)-3-(1,3-benzothiazol-2-yl)-4-[2-(propan-2-yloxy)phenyl]but-3-enoate
Trypanosoma cruzi
-
-
0.15
(3E)-3-(1,3-benzothiazol-2-yl)-4-[2-methyl-5-(trifluoromethyl)phenyl]but-3-enoate
Trypanosoma cruzi
-
-
0.0181
(4R)-2-(2-carboxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0107
(4R)-2-(2-carboxyphenyl)-3-(chloroacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00192
(4R)-2-(2-carboxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00028
(4R)-2-(2-carboxyphenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0123
(4R)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00162
(4R)-2-(2-hydroxy-3-methoxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0202
(4R)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00065
(4R)-2-(2-hydroxyphenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0225
(4R)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00187
(4R)-2-(2-nitrophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0234
(4R)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00247
(4R)-2-(4-cyanophenyl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00081
(4R)-2-(4-cyanophenyl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0431
(4R)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00289
(4R)-2-(furan-2-yl)-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00098
(4R)-2-(furan-2-yl)-3-glycyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0213
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00121
(4R)-2-phenyl-3-(phenylacetyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00792
(4R)-3-(chloroacetyl)-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00584
(4R)-3-(chloroacetyl)-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00765
(4R)-3-(chloroacetyl)-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00864
(4R)-3-(chloroacetyl)-2-(4-cyanophenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0129
(4R)-3-(chloroacetyl)-2-(furan-2-yl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00753
(4R)-3-(chloroacetyl)-2-phenyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00014
(4R)-3-glycyl-2-(2-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00021
(4R)-3-glycyl-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00102
(4R)-3-glycyl-2-(2-nitrophenyl)-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.00053
(4R)-3-glycyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid
influenza A virus
-
pH and temperature not specified in the publication
0.0032
(6aS,12aS)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-ol
Clostridium perfringens
-
-
0.00008
1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one
Clostridium perfringens
pH 5.0, 37°C
0.11 - 0.76
1,3,8-trihydroxy-6-methylanthracene-9,10-dione
0.71 - 1
1,8-dihydroxyanthracene-9,10-dione
0.0243
2'-methoxy-isoliquiritigenin
unidentified influenza virus
-
-
0.2
2,3-dehydro-2-deoxy-N-acetylneuraminic acid
Streptococcus pneumoniae
-
-
0.034
2,6-anhydro-3,5-dideoxy-5-glycolylamido-D-glycero-D-galactonon-2-enonic acid
Homo sapiens
-
pH 5.5, 37°C
2.1
2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2-enonic acid
Homo sapiens
-
pH 5.5, 37°C
0.0083
2,6-anhydro-5-(2-azidoacetamido)-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid
Homo sapiens
-
pH 5.5, 37°C
0.013 - 10
2,6-anhydro-9-azido-3,5,9-trideoxy-5-(2-hydroxyacetamido)-D-glycero-D-galacto-non-2-enonic acid
0.013 - 16
2,6-anhydro-9-azido-5-(2-azidoacetamido)-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
0.0000223 - 0.0000256
2-((E)-4'-hydroxyphenylidene)-4,6-dihydroxy-2,3-dihydrobenzofuran-3-one
0.000022 - 0.0000229
2-((E)-4'-hydroxyphenylidene)-6-hydroxy-2,3-dihydrobenzofuran-3-one
0.022 - 0.16
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
1
2-(3,4-dihydroxyphenyl)-4H-chromene-3,5,7-triol
0.21
2-([4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-yl]carbamoyl)cyclohexanecarboxylate
Trypanosoma cruzi
-
-
0.0086 - 3.7
2-deoxy-2,3-dehydro-N-acetylneuraminic acid
0.039 - 0.13
3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
0.11 - 0.23
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.58
3-(acetylamino)-4-morpholin-4-ylbenzoic acid
Trypanosoma cruzi
-
-
0.7
3-amino-4-(benzylthio)benzoic acid
Trypanosoma cruzi
-
-
0.74
3-amino-4-(pyridin-3-ylamino)benzoic acid
Trypanosoma cruzi
-
-
1.2
3-amino-4-[(phenylacetyl)amino]benzoic acid
Trypanosoma cruzi
-
-
1
3-[(aminoacetyl)amino]-4-(benzylthio)benzoic acid
Trypanosoma cruzi
-
-
0.76
3-[(diaminomethylene)amino]-4-[(methylamino)carbonyl]benzoic acid
Trypanosoma cruzi
-
-
0.014 - 0.13
4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
0.000032
4-(acetylamino)-3,5-bis(guanidino)-2-ethoxybenzoic acid
influenza A virus
-
pH 3.5, 37°C
0.54
4-(acetylamino)-3-(hydroxymethyl)benzoic acid
Trypanosoma cruzi
-
-
0.000041
4-(acetylamino)-5-(guanidino)-2-(cyclopentyloxy)benzoic acid
influenza A virus
-
pH 3.5, 37°C
0.00004
4-(acetylamino)-5-(guanidino)-2-butoxybenzoic acid
influenza A virus
-
pH 3.5, 37°C
0.000049
4-(acetylamino)-5-(guanidino)-2-isopropoxybenzoic acid
influenza A virus
-
pH 3.5, 37°C
0.552 - 5
4-acetamido-5-(biphenyl-4-ylcarboxamido)-2-fluorobenzoic acid
0.05 - 0.055
5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.1 - 0.13
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
0.07 - 0.36
5,7-dihydroxy-2-(2-hydroxyphenyl)-4H-chromen-4-one
0.078 - 0.57
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
1
5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
0.34 - 0.89
5,7-dihydroxy-2-phenyl-4H-chromen-4-one
0.23 - 0.38
5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
0.01
5-(acetylamino)-2,6-anhydro-3,5,9-trideoxy-9-(pentanoylamino)-L-glycero-L-altro-non-2-enonic acid
Homo sapiens
-
0.565
5-(acetylamino)-2,6-anhydro-3,5,9-trideoxy-9-[(3-methylbutanoyl)amino]-L-glycero-L-altro-non-2-enonic acid
Homo sapiens
-
0.135
5-(acetylamino)-2,6-anhydro-9-[(cyclopentylcarbonyl)amino]-3,5,9-trideoxy-L-glycero-L-altro-non-2-enonic acid
Homo sapiens
-
0.44
5-(acetylamino)-6-aminopyridine-2-carboxylic acid
Trypanosoma cruzi
-
-
0.54
5-(ethanethioylamino)pyridine-2-carboxylic acid
Trypanosoma cruzi
-
-
0.013 - 3
5-acetamido-2,6-anhydro-3,5-dideoxy-9-O-methyl-D-glycero-D-galacto-non-2-enonic acid
0.018
5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galactonon-2-enonic acid
Homo sapiens
-
pH 5.5, 37°C
0.0087 - 3.3
5-acetamido-2,6-anhydro-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
1 - 10
5-acetamido-9-aminopropyl-2,6-anhydro-3,5,9-trideoxy-D-glycero-D-galacto-non-2-enonic acid
1
5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.14 - 1
5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
1
5-methyl-4-methylidene-2-phenyl-4H-chromene
0.00058
6-chloro-9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylate
Trypanosoma cruzi
-
in 50 mM Tris-HCl pH7.5, at 25°C
0.1
6-chloro-9,10-dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Homo sapiens
-
IC50 above 0.1 mM, in 50 mM Tris-HCl pH 7.5, at 25°C
0.47 - 1
7-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
0.43 - 0.8
9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
0.0000012
A-315675
Influenza A virus (A/Brisbane/59/2007(H1N1))
-
-
0.0000289 - 0.0000457
apigenin
0.0135
Berberine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.00157 - 0.00755
calopocarpin
0.0251
coptisine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.00228 - 0.02203
cristacarpin
0.000245
cudratricusxanthone
Clostridium perfringens
pH 5.0, 37°C
0.000228
cudraxanthone L
Clostridium perfringens
pH 5.0, 37°C
0.000186
cudraxanthone M
Clostridium perfringens
pH 5.0, 37°C
0.006
curcumin
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0413
dehydrocorybulbine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.00639 - 0.02954
demethylmedicarpin
0.000026 - 0.0000463
dinatin
0.00204 - 0.02774
erystagallin A
0.02639
erysubin D
0.0013 - 0.01948
erysubin E
0.0462 - 0.0771
erythribyssin D
0.00279 - 0.02714
erythribyssin L
0.07773 - 0.2054
erythribyssin M
0.00035 - 0.00132
erythribyssin O
0.00209 - 0.0033
eryvarin D
4.43
Galp(beta1,2)Galf(beta1,4)GlcNAc
Trypanosoma cruzi
-
-
0.85
Galp(beta1,2)Galf(beta1,4)GlcNAcOBn
Trypanosoma cruzi
-
-
1.67
Galp(beta1,2)Galf(beta1,4)GlcNAcol
Trypanosoma cruzi
-
-
0.86
Galp(beta1,2)[Galp(beta1,3)]Gal
Trypanosoma cruzi
-
-
1.13
Galp(beta1,2)[Galp(beta1,3)]GalOBn
Trypanosoma cruzi
-
-
0.93
Galp(beta1,2)[Galp(beta1,3)]Galol
Trypanosoma cruzi
-
-
0.85
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAc
Trypanosoma cruzi
-
-
0.7
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
Trypanosoma cruzi
-
-
0.61
Galp(beta1,2)[Galp(beta1,3)]Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
Trypanosoma cruzi
-
-
0.76
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAc
Trypanosoma cruzi
-
-
1.14
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcOBn
Trypanosoma cruzi
-
-
1.26
Galp(beta1,3)Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
Trypanosoma cruzi
-
-
2.22
Galp(beta1,6)GlcNAc
Trypanosoma cruzi
-
-
1.11
Galp(beta1,6)GlcNAcOBn
Trypanosoma cruzi
-
-
0.98
Galp(beta1,6)GlcNAcol
Trypanosoma cruzi
-
-
0.86 - 1.33
Galp(beta1,6)[Galf(beta1,4)]GlcNAc
0.94
Galp(beta1,6)[Galf(beta1,4)]GlcNAcol
Trypanosoma cruzi
-
-
0.0969
glaucine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0031
glycyrol
unidentified influenza virus
-
-
0.0924
isoglycyrol
unidentified influenza virus
-
-
0.009
isoliquiritigenin
unidentified influenza virus
-
-
0.124
isoliquiritin
unidentified influenza virus
-
-
0.0129
isoliquiritin apioside
unidentified influenza virus
-
-
0.01412 - 0.06475
isoneorautenol
0.037
Jatrorrhizine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0364
kumatakenin
unidentified influenza virus
-
-
0.00000311 - 0.00804
laninamivir
0.0278
licocoumarone
unidentified influenza virus
-
-
0.0206
licoflavonol
unidentified influenza virus
-
-
0.0468
liquiritigenin
unidentified influenza virus
-
-
0.0823
liquiritin
unidentified influenza virus
-
-
0.0182
liquiritin apioside
unidentified influenza virus
-
-
0.0000326 - 0.0000533
luteolin
0.000186
macluraxanthone
Clostridium perfringens
pH 5.0, 37°C
0.000036
methyl 4-(acetylamino)-3,5-bis(guanidino)-2-ethoxybenzoate
influenza A virus
-
pH 3.5, 37°C
0.000038
methyl 4-(acetylamino)-5-amino-2-(3-methylbutoxy)benzoate
influenza A virus
-
pH 3.5, 37°C
0.017 - 0.15
myricetin
0.0189
N-acetyl-2,3-dehydro-2-deoxyneuraminic acid
Clostridium perfringens
-
at pH 7.2 and 37°C
0.6
N-acetylneuraminic acid
Streptococcus pneumoniae
-
-
0.01982 - 0.05311
neorautenol
0.0000000032 - 0.14252
oseltamivir
0.0000003 - 0.003367
oseltamivir carboxylate
0.0128
palmatine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0000003 - 0.0344
peramivir
0.0314 - 0.03355
phaseollin
0.0652
pseudocoptisine
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0326
pseudodehydrocorydaline
Clostridium perfringens
-
in 50 mM sodium acetate buffer (pH 5.0), at 22°C
0.0014
pterocarpin
Clostridium perfringens
-
-
0.02534
quercetin
Clostridium perfringens
-
-
0.0422
siastatin B
Clostridium perfringens
-
at pH 7.2 and 37°C
0.00201 - 0.01159
sophorapterocarpan A
0.0000277 - 0.0000512
sulfuretin
0.0000005 - 0.03936
zanamivir