3.2.1.103: keratan-sulfate endo-1,4-beta-galactosidase

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For detailed information about keratan-sulfate endo-1,4-beta-galactosidase, go to the full flat file.

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Synonyms

E-beta-G, endo-beta-galactosidase, galactosidase, keratosulfate endo- beta-, keratan sulfate endogalactosidase, keratanase

ECTree

     3 Hydrolases

         3.2 Glycosylases

             3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds

                3.2.1.103 keratan-sulfate endo-1,4-beta-galactosidase

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Results	in table
30	AA Sequence
6	Application
1	CAS Registry Number
1	Cloned(Commentary)
20	Disease/ Diagnostics
1	General Stability
24	Inhibitors
3	KM Value [mM]
7	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
20	Organism
2	Pathway
7	pH Optimum
10	pH Stability
7	Purification (Commentary)
1	Reaction
1	Reaction Type
20	Reference
3	Source Tissue
6	Specific Activity [micromol/min/mg]
6	Storage Stability
75	Substrates and Products (Substrate)
2	Subunits
7	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]

Disease

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Disease on EC 3.2.1.103 - keratan-sulfate endo-1,4-beta-galactosidase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Arthritis

Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.

8609216

Carcinoma

Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.

8910032

Mucopolysaccharidosis IV

Development of Substrate Degradation Enzyme Therapy for Mucopolysaccharidosis IVA Murine Model.

31450640

Neoplasms

Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.

8910032

Neoplasms

[Histochemical studies of bladder tumors]

2942017

Rheumatic Diseases

Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate.

9627011

Spondylitis

Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.

8609216

Teratocarcinoma

The linear tetrasaccharide, Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc, isolated from radiolabeled teratocarcinoma poly-N-acetyllactosaminoglycan resists the action of E. freundii endo-beta-galactosidase.

2535473

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