3.2.1.101: mannan endo-1,6-alpha-mannosidase
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For detailed information about mannan endo-1,6-alpha-mannosidase, go to the full flat file.
Reaction
Synonyms
BcGH76, endo-1,6-alpha-mannanase, endo-alpha(1->6)mannanase, endo-alpha-1->6-D-mannanase, endo-alpha1->6-D-mannase, endo-alpha1->6-mannanase, endoM, mannanase, endo-1,6-alpha-
ECTree
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Crystallization
Crystallization on EC 3.2.1.101 - mannan endo-1,6-alpha-mannosidase
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the non-hydrolyzable S-linked azasugars, 1,6-alpa-mannosylthio- and 1,6-alpha-mannobiosylthioisofagomine bind with high affinity to the enzyme. X-ray crystallography shows an atypical interaction of the isofagomine nitrogen with the catalytic acid/base. Molecular dynamics simulations reveal that the atypical binding results from sulfur perturbing the most stable form away from the nucleophile interaction preferred for the O-linked congener