3.11.1.1: phosphonoacetaldehyde hydrolase
This is an abbreviated version!
For detailed information about phosphonoacetaldehyde hydrolase, go to the full flat file.
Word Map on EC 3.11.1.1
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3.11.1.1
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phosphorus
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phosphonates
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carbon-phosphorus
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dehalogenase
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phosphonoacetate
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2-aminoethylphosphonate
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schiff-base
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organophosphonate
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phosphonopyruvate
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phosphomutase
- 3.11.1.1
- phosphorus
- phosphonates
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carbon-phosphorus
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dehalogenase
- phosphonoacetate
- 2-aminoethylphosphonate
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schiff-base
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organophosphonate
- phosphonopyruvate
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phosphomutase
Reaction
Synonyms
2-phosphonoacetaldehyde phosphonohydrolase, 2-phosphonoacetylaldehyde phosphonohydrolase, hydrolase, phosphonoacetylaldehyde, P-Ald hydrolase, phosphonatase
ECTree
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General Information
General Information on EC 3.11.1.1 - phosphonoacetaldehyde hydrolase
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evolution
metabolism
physiological function
additional information
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the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview
evolution
the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview
evolution
the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview
evolution
the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview
evolution
-
the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview
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the enzyme is involved in the phosphonatase pathway of 2-aminoethylphosphonic acid degradation, overview
metabolism
the enzyme is involved in biodegradation pathway of ciliatine or 2-aminoethylphosphonic acid, a two-step process. The first reaction reported as transamination is carried out by 2-aminoethylphosphonic acid transaminase and leads to the formation of phosphonoacetaldehyde and corresponding amino acid. The next step includes hydrolytic cleavage of the C-P bond within the phosphonoacetaldehyde molecule and results in formation of inorganic phosphate and acetaldehyde, carried out by the phosphonoacetaldehyde hydrolase. The phophonoacetaldehyde hydrolase hydrolyzes
metabolism
the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Expression of the operon is substrate-inducible, mediated by the product of an adjacent gene that encodes a LysR-like transcriptional activator, LTTR
metabolism
the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Expression of the operon is substrate-inducible, mediated by the product of an adjacent gene that encodes a LysR-like transcriptional activator, LTTR
metabolism
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the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Phosphate-starvation-inducible expression of this pathway as a part of the Pho regulon
metabolism
the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Phosphate-starvation-inducible expression of this pathway as a part of the Pho regulon
metabolism
-
the enzyme is involved in biodegradation pathway of ciliatine or 2-aminoethylphosphonic acid, a two-step process. The first reaction reported as transamination is carried out by 2-aminoethylphosphonic acid transaminase and leads to the formation of phosphonoacetaldehyde and corresponding amino acid. The next step includes hydrolytic cleavage of the C-P bond within the phosphonoacetaldehyde molecule and results in formation of inorganic phosphate and acetaldehyde, carried out by the phosphonoacetaldehyde hydrolase. The phophonoacetaldehyde hydrolase hydrolyzes
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metabolism
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the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Expression of the operon is substrate-inducible, mediated by the product of an adjacent gene that encodes a LysR-like transcriptional activator, LTTR
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the enzyme is involved in biodegradation pathway of ciliatine or 2-aminoethylphosphonic acid
physiological function
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the enzyme is involved in biodegradation pathway of ciliatine or 2-aminoethylphosphonic acid
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the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile
additional information
the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile
additional information
the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile
additional information
the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile
additional information
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the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile
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