3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

This is an abbreviated version!
For detailed information about guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, go to the full flat file.

Word Map on EC 3.1.7.2

Reaction

guanosine 3',5'-bis(diphosphate)
+
H2O
=
GDP
+
diphosphate

Synonyms

ppGpp-3'-pyrophosphohydrolase, ppGpp phosphohydrolase, 3',5'-bis(diphosphate) 3'-pyrophosphate hydrolase, pyrophosphatase, guanosine 3',5'-bis(diphosphate) 3'-, guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase, penta-phosphate guanosine-3'-pyrophosphohydrolase, penta-phosphate guanosine-3'-diphosphohydrolase, guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, (ppGpp)ase, ppGpp hydrolase, RelSeq, (p)ppGpp synthetase/hydrolase, MESH1, HDDC3, metazoan SpoT homolog-1

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.7 Diphosphoric-monoester hydrolases
                3.1.7.2 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

Reference

Reference on EC 3.1.7.2 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Belitzky, B.R.; Shakulov, R.S.
Functioning of spo T gene product in Bacillus subtilis cells
FEBS Lett.
138
226-228
1982
Bacillus subtilis
Manually annotated by BRENDA team
Sy, J.
Activation of ppGpp-3-pyrophosphohydrolase by a supernatant factor and ATP
J. Biol. Chem.
255
10056-10059
1980
Escherichia coli
Manually annotated by BRENDA team
Richter, D.
Uncharged tRNA inhibits guanosine 3,5-bis (diphosphate) 3-pyrophosphohydrolase [ppGppase], the spoT gene product, from Escherichia coli
Mol. Gen. Genet.
178
325-327
1980
Escherichia coli
Manually annotated by BRENDA team
Richter, D.
In vitro degradation of guanosine 3,5-bis(diphosphate) [ppGpp] by the spoT gene product [ppGppase] from auxotrophic strains of Escherichia coli: effects of various antibiotics and drugs
Arch. Microbiol.
124
229-232
1980
Escherichia coli
Manually annotated by BRENDA team
Richter, D.; Fehr, S.; Harder, R.
The guanosine 3,5-bis(diphosphate) (ppGpp) cycle. Comparison of synthesis and degradation of guanosine 3,5-bis(diphosphate) in various bacterial systems
Eur. J. Biochem.
99
57-64
1979
Geobacillus stearothermophilus, Brevibacillus brevis, Bacillus subtilis, Escherichia coli
Manually annotated by BRENDA team
An, G.; Justesen, J.; Watson, R.J.; Friesen, J.D.
Cloning the spoT gene of Escherichia coli: identification of the spoT gene product
J. Bacteriol.
137
1100-1110
1979
Escherichia coli
Manually annotated by BRENDA team
Heinemeyer, E.A.; Richter, D.
Characterization of the guanosine 5-triphosphate 3-diphosphate and guanosine 5-diphosphate 3-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli
Biochemistry
17
5368-5372
1978
Escherichia coli
Manually annotated by BRENDA team
Xiao, H.; Kalman, M.; Ikehara, K.; Zemel, S.; Glaser, G.; Cashel, M.
Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations
J. Biol. Chem.
266
5980-5990
1991
Escherichia coli
Manually annotated by BRENDA team
Murray, K.D.; Bremer, H.
Control of spoT-dependent ppGpp synthesis and degradation in Escherichia coli
J. Mol. Biol.
259
41-57
1996
Escherichia coli
Manually annotated by BRENDA team
Avarbock, D.; Avarbock, A.; Rubin, H.
Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA ribosome mRNA elMtb complex
Biochemistry
39
11640-11648
2000
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Mechold, U.; Murphy, H.; Brown, L.; Cashel, M.
Intramolecular regulation of the opposing (p)ppGpp catalytic activities of RelSeq, the Rel/Spo enzyme from Streptococcus equisimilis
J. Bacteriol.
184
2878-2888
2002
Streptococcus dysgalactiae subsp. equisimilis, Streptococcus dysgalactiae subsp. equisimilis H46A
Manually annotated by BRENDA team
Avarbock, A.; Avarbock, D.; Teh, J.S.; Buckstein, M.; Wang, Z.m.; Rubin, H.
Functional Regulation of the Opposing (p)ppGpp Synthetase/Hydrolase Activities of RelMtb from Mycobacterium tuberculosis
Biochemistry
44
9913-9923
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Sun, D.; Lee, G.; Lee, J.H.; Kim, H.Y.; Rhee, H.W.; Park, S.Y.; Kim, K.J.; Kim, Y.; Kim, B.Y.; Hong, J.I.; Park, C.; Choy, H.E.; Kim, J.H.; Jeon, Y.H.; Chung, J.
A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses
Nat. Struct. Mol. Biol.
17
1188-1194
2010
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Fernandez-Coll, L.; Cashel, M.
Contributions of SpoT hydrolase, SpoT synthetase, and RelA synthetase to carbon source diauxic growth transitions in Escherichia coli
Front. Microbiol.
9
1802
2018
Escherichia coli (P0AG24)
Manually annotated by BRENDA team
Ronneau, S.; Caballero-Montes, J.; Coppine, J.; Mayard, A.; Garcia-Pino, A.; Hallez, R.
Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domain
Nucleic Acids Res.
47
843-854
2019
Caulobacter vibrioides (A0A0H3C9W6), Caulobacter vibrioides, Caulobacter vibrioides NA1000 (A0A0H3C9W6)
Manually annotated by BRENDA team
Gratani, F.; Horvatek, P.; Geiger, T.; Borisova, M.; Mayer, C.; Grin, I.; Wagner, S.; Steinchen, W.; Bange, G.; Velic, A.; Macek, B.; Wolz, C.
Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus
PLoS Genet.
14
e1007514
2018
Staphylococcus aureus (W8U368)
Manually annotated by BRENDA team
Lee, J.W.; Park, Y.H.; Seok, Y.J.
Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift in Escherichia coli
Proc. Natl. Acad. Sci. USA
115
E6845-E6854
2018
Escherichia coli (P0AG24), Escherichia coli
Manually annotated by BRENDA team