3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

This is an abbreviated version!
For detailed information about guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, go to the full flat file.

Word Map on EC 3.1.7.2

Reaction

guanosine 3',5'-bis(diphosphate)
+
H2O
=
GDP
+
diphosphate

Synonyms

ppGpp-3'-pyrophosphohydrolase, ppGpp phosphohydrolase, 3',5'-bis(diphosphate) 3'-pyrophosphate hydrolase, pyrophosphatase, guanosine 3',5'-bis(diphosphate) 3'-, guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase, penta-phosphate guanosine-3'-pyrophosphohydrolase, penta-phosphate guanosine-3'-diphosphohydrolase, guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, (ppGpp)ase, ppGpp hydrolase, RelSeq, (p)ppGpp synthetase/hydrolase, MESH1, HDDC3, metazoan SpoT homolog-1

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.7 Diphosphoric-monoester hydrolases
                3.1.7.2 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

Engineering

Engineering on EC 3.1.7.2 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E319Q
mutant lacks (p)ppGpp synthase activity but retains hydrolase activity
D81A
-
loss of hydrolytic activity with retention of synthesis
G241E
-
loss of synthetic activity and retention of hydrolysis
H344Y
-
loss of synthetic activity and retention of hydrolysis
H80A
-
loss of hydrolytic activity with retention of synthesis
DELTA395-738
-
frament contains both synthesis and hydrolysis activities
DElTA1-86/DELTA395-738
-
contains only (p)ppGpp synthesis activity, no hydrolysis activity
DELTA182-738
-
fragment contains only (p)ppGpp hydrolysis activity, no synthesis activity
additional information