3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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For detailed information about guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, go to the full flat file.

Reaction

Synonyms

(p)ppGpp synthetase/hydrolase, (ppGpp)ase, 3',5'-bis(diphosphate) 3'-pyrophosphate hydrolase, guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase, guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, HDDC3, MESH1, metazoan SpoT homolog-1, penta-phosphate guanosine-3'-diphosphohydrolase, penta-phosphate guanosine-3'-pyrophosphohydrolase, ppGpp hydrolase, ppGpp phosphohydrolase, ppGpp-3'-pyrophosphohydrolase, pyrophosphatase, guanosine 3',5'-bis(diphosphate) 3'-, RelSeq

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.7 Diphosphoric-monoester hydrolases

                3.1.7.2 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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Results	in table
1	Activating Compound
7120	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
18	Disease/ Diagnostics
7	General Information
10	Inhibitors
2	kcat/KM [mM/s]
2	KM Value [mM]
6	Localization
19	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
12	PDB ID
2	pH Optimum
11	Protein Variants
4	Purification (Commentary)
4	Reaction
1	Reaction Type
23	Reference
4	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
2	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 3.1.7.2 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E319Q

Escherichia coli

P0AG24

mutant lacks (p)ppGpp synthase activity but retains hydrolase activity

750643

D81A

Mycobacterium tuberculosis

-

loss of hydrolytic activity with retention of synthesis

661218

DElTA1-86/DELTA395-738

Mycobacterium tuberculosis

-

contains only (p)ppGpp synthesis activity, no hydrolysis activity

661218

DELTA182-738

Mycobacterium tuberculosis

-

fragment contains only (p)ppGpp hydrolysis activity, no synthesis activity

661218

DELTA395-738

Mycobacterium tuberculosis

-

frament contains both synthesis and hydrolysis activities

661218

G241E

Mycobacterium tuberculosis

-

loss of synthetic activity and retention of hydrolysis

661218

H344Y

Mycobacterium tuberculosis

-

loss of synthetic activity and retention of hydrolysis

661218

H80A

Mycobacterium tuberculosis

-

loss of hydrolytic activity with retention of synthesis

661218

additional information

3 entries

additional information

Drosophila melanogaster

-

Mesh1 deletion by imprecise excision of a P-element from the Drosophila Mesh1 G3858 allele, resulting in the Drosophila Mesh1 null allele, Mesh1 5A3. The Mesh1 null mutant is much more susceptible than wild-type flies to death from amino acid starvation, and this susceptibility is also completely rescued by Mesh1 expression

716313

additional information

Streptococcus dysgalactiae subsp. equisimilis

-

diverse deletion mutants show synthesis and degradation activities differing from those of full-length enzyme

651696

additional information

Streptococcus dysgalactiae subsp. equisimilis H46A

-

diverse deletion mutants show synthesis and degradation activities differing from those of full-length enzyme

-