3.1.7.2: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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For detailed information about guanosine-3',5'-bis(diphosphate) 3'-diphosphatase, go to the full flat file.

Reaction

Synonyms

(p)ppGpp synthetase/hydrolase, (ppGpp)ase, 3',5'-bis(diphosphate) 3'-pyrophosphate hydrolase, guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase, guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase, HDDC3, MESH1, metazoan SpoT homolog-1, penta-phosphate guanosine-3'-diphosphohydrolase, penta-phosphate guanosine-3'-pyrophosphohydrolase, ppGpp hydrolase, ppGpp phosphohydrolase, ppGpp-3'-pyrophosphohydrolase, pyrophosphatase, guanosine 3',5'-bis(diphosphate) 3'-, RelSeq

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.7 Diphosphoric-monoester hydrolases

                3.1.7.2 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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1	Activating Compound
7120	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
18	Disease/ Diagnostics
7	General Information
10	Inhibitors
2	kcat/KM [mM/s]
2	KM Value [mM]
6	Localization
19	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
23	Organism
5	Pathway
12	PDB ID
2	pH Optimum
11	Protein Variants
4	Purification (Commentary)
4	Reaction
1	Reaction Type
23	Reference
4	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
2	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Disease

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Disease on EC 3.1.7.2 - guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Abscess

Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.

25545155

Breast Neoplasms

MicroRNA related polymorphisms and breast cancer risk.

25390939

Infections

Transcriptome analysis of Enterococcus faecalis during mammalian infection shows cells undergo adaptation and exist in a stringent response state.

25545155

Neoplasms

The regulation of ferroptosis by MESH1 through the activation of the integrative stress response.

34294679

Starvation

A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis.

33619274

Starvation

A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.

20818390

Starvation

Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.

31648246

Tuberculosis

Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein.

33067840

Tuberculosis

Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis.

16026164

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