3.1.6.6: choline-sulfatase

This is an abbreviated version!
For detailed information about choline-sulfatase, go to the full flat file.

Reaction

Synonyms

BetC, choline sulfatase, choline sulphatase, sulfatase, choline

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.6 Sulfuric-ester hydrolases

                3.1.6.6 choline-sulfatase

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Results	in table
5	Activating Compound
4358	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
4	Expression
2	General Information
38	Inhibitors
11	kcat/KM [mM/s]
2	Ki Value [mM]
15	KM Value [mM]
13	Metals/Ions
4	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
24	PDB ID
4	pH Optimum
3	pH Stability
1	Posttranslational Modification
6	Protein Variants
2	Purification (Commentary)
3	Reaction
1	Reaction Type
15	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
37	Substrates and Products (Substrate)
1	Subunits
8	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
11	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.1.6.6 - choline-sulfatase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

4-methylumbelliferyl sulfate + H2O

methylumbelliferone + sulfate

Sinorhizobium meliloti

O69787

-

749790

-

-

?

4-nitrophenyl methylphosphate + H2O

4-nitrophenol + methylphosphate

Sinorhizobium meliloti

O69787

-

751335

-

-

?

4-nitrophenyl methylphosphonate + H2O

4-nitrophenol + phosphonate

Sinorhizobium meliloti

O69787

-

751335

-

-

?

4-nitrophenyl phosphate + H2O

4-nitrophenol + phosphate

Sinorhizobium meliloti

O69787

-

751335

-

-

?

4-nitrophenyl sulfate + H2O

4-nitrophenol + sulfate

2 entries

amylose polysulfate + H2O

amylose + sulfate

Pseudomonas nitroreducens

-

slightly hydrolyzed

135658

-

-

?

choline O-sulfate + H2O

choline + sulfate

Sinorhizobium meliloti

O69787

-

751335

-

-

?

choline sulfate + H2O

choline + sulfate

19 entries

choline-O-sulfate + H2O

choline + sulfate

2 entries

phosphoryl choline + H2O

choline + phosphate

Sinorhizobium meliloti

O69787

-

751335

-

-

?

phosphorylcholine + H2O

choline + phosphate

Sinorhizobium meliloti

-

less than 20% activity compared to choline sulfate as substrat

135665

-

-

?

additional information

?

-

Pseudomonas putida

-

enzyme is unrelated to osmoprotection

681996

-

-

?

4-nitrophenyl sulfate + H2O

4-nitrophenol + sulfate

Sinorhizobium meliloti

O69787

-

749790, 751335

-

-

?

4-nitrophenyl sulfate + H2O

4-nitrophenol + sulfate

Sinorhizobium meliloti

-

-

751335

-

-

?

choline sulfate + H2O

choline + sulfate

Aspergillus nidulans

-

-

135660, 135664

-

-

?

choline sulfate + H2O

choline + sulfate

Aspergillus nidulans

-

after sulfur starvation

135660

-

-

?

choline sulfate + H2O

choline + sulfate

Aspergillus nidulans

-

not in sulfur-sufficient mycelia of wild-type

135660

-

-

?

choline sulfate + H2O

choline + sulfate

Neurospora crassa

-

-

135661, 135662

-

-

?

choline sulfate + H2O

choline + sulfate

Neurospora crassa

-

sulfur metabolism controlled by the Cys-3 and Scon regulatory genes

135661, 135662

-

-

?

choline sulfate + H2O

choline + sulfate

Neurospora crassa

-

enzyme normally repressed, mutant with derepressed enzyme synthesis

135661, 135662

-

-

?

choline sulfate + H2O

choline + sulfate

Penicillium chrysogenum

-

-

135659

-

-

?

choline sulfate + H2O

choline + sulfate

Penicillium chrysogenum

-

reverse reaction not demonstrated

135659

-

-

ir

choline sulfate + H2O

choline + sulfate

Pseudomonas aeruginosa

-

reverse reaction not demonstrated

135659

-

-

ir

choline sulfate + H2O

choline + sulfate

Pseudomonas aeruginosa

-

substrate-induced

135659

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas nitroreducens

-

-

135658

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas nitroreducens

-

substrate-induced

135658

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas sp.

-

-

135663

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas sp.

-

substrate-induced

135663

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas sp. V-A

-

-

135663

-

-

?

choline sulfate + H2O

choline + sulfate

Pseudomonas sp. V-A

-

substrate-induced

135663

-

-

?

choline sulfate + H2O

choline + sulfate

Sinorhizobium meliloti

-

-

135665

-

135665

?

choline sulfate + H2O

choline + sulfate

Sinorhizobium meliloti

O69787

-

749790

-

-

?

choline sulfate + H2O

choline + sulfate

Sinorhizobium meliloti

-

is metabolized into glycine betaine

135665

-

-

?

choline-O-sulfate + H2O

choline + sulfate

Pseudomonas sp.

D8LAR6

-

713992

-

-

?

choline-O-sulfate + H2O

choline + sulfate

Pseudomonas sp. ATCC 19151

D8LAR6

-

713992

-

-

?