3.1.5.1: dGTPase

This is an abbreviated version!
For detailed information about dGTPase, go to the full flat file.

Reaction

Synonyms

deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine tri-oder deoxyguanosine triphosphatase, deoxyguanosine triphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase, More, phosphatase, deoxyguanosine tri

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.5 Triphosphoric-monoester hydrolases

                3.1.5.1 dGTPase

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2	Activating Compound
3916	AA Sequence
1	Application
1	CAS Registry Number
3	Cloned(Commentary)
2	Crystallization (Commentary)
2	General Information
1	General Stability
6	Inhibitors
6	KM Value [mM]
6	Metals/Ions
6	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
23	Organism
4	Pathway
97	PDB ID
1	pH Optimum
1	Protein Variants
17	Purification (Commentary)
1	Reaction
1	Reaction Type
23	Reference
2	Storage Stability
52	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
18	Temperature Stability [°C]
1	Turnover Number [1/s]

General Information

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General Information on EC 3.1.5.1 - dGTPase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Escherichia coli

-

blockage of the alternative dUMP phosphatase pathway for deoxyribose-1-phosphate generation greatly exacerbates the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death

716268

physiological function

Escherichia coli

-

the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreases with increased expression level of the dgt gene. As expected, this dgt-mediated effect is dependent on the DeoD purine nucleoside phosphorylase. ThyA strains experience growth difficulties upon nutritional shift-up, the dgt gene facilitates adaptation to the new growth conditions

716268