3.1.5.1: dGTPase

This is an abbreviated version!
For detailed information about dGTPase, go to the full flat file.

Word Map on EC 3.1.5.1

Reaction

dGTP
+
H2O
=
deoxyguanosine
+
Triphosphate

Synonyms

More, deoxyguanosine 5-triphosphate triphosphohydrolase, phosphatase, deoxyguanosine tri, deoxyguanosine tri-oder deoxyguanosine triphosphatase, deoxy-GTPase, deoxyguanosine triphosphate triphosphohydrolase, dGTP triphosphohydrolase, dGTPase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.5 Triphosphoric-monoester hydrolases
                3.1.5.1 dGTPase

General Information

General Information on EC 3.1.5.1 - dGTPase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreases with increased expression level of the dgt gene. As expected, this dgt-mediated effect is dependent on the DeoD purine nucleoside phosphorylase. ThyA strains experience growth difficulties upon nutritional shift-up, the dgt gene facilitates adaptation to the new growth conditions
metabolism
-
blockage of the alternative dUMP phosphatase pathway for deoxyribose-1-phosphate generation greatly exacerbates the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death