3.1.4.45: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
This is an abbreviated version!
For detailed information about N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, go to the full flat file.
Word Map on EC 3.1.4.45
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3.1.4.45
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mucopolysaccharidosis
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sanfilippo
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heparan
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mpsiiib
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hgsnat
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man-6-p
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phosphomannosyl
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n-acetylglucosamine-1-phosphotransferase
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biotechnology
- 3.1.4.45
- mucopolysaccharidosis
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sanfilippo
- heparan
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mpsiiib
- hgsnat
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man-6-p
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phosphomannosyl
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n-acetylglucosamine-1-phosphotransferase
- biotechnology
Reaction
Synonyms
2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, alpha-N-acetylglucosaminylphosphodiesterase, BACOVA_00430, GH89, GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase, GlcNAc-1-phosphodiester-N-acetylglucosaminidase, lysosomal alpha-N-acetyl-glucosaminidase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate uncovering enzyme, mannose 6-phosphate-uncovering enzyme, N-acetylglucosamine-1-phosphodiester N-acetylglucosaminidase, NAGLU, phosphodiester alpha-GlcNAcase, phosphodiester glycosidase, UCE, uncovering enzyme
ECTree
3.1.4.45 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.1.4.45 - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl alpha-N-acetyl-D-glucosaminide + H2O
2,4-dinitrophenol + alpha-N-acetyl-D-glucosamine
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?
4-nitrophenyl alpha-N-acetyl-D-glucosaminide + H2O
4-nitrophenol + alpha-N-acetyl-D-glucosamine
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-
-
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?
6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-D-mannose + H2O
N-acetyl-D-glucosamine + 6-phospho-D-mannose
6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-D-mannose + H2O
N-acetyl-D-glucosamine + D-mannose 6-phosphate
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-
-
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?
6-O-(N-acetyl-alpha-D-glucosaminyl)phosphono-D-mannopyranose + H2O
N-acetyl-D-glucosamine + 6-O-phosphono-D-mannopyranose
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-
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
methyl 6-O-(N-acetyl-D-glucosaminyl)phospho-alpha D-mannose + H2O
N-acetyl-D-glucosamine + methyl 6-phospho-alpha-D-mannopyranoside
N-[6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine + H2O
N-acetyl-D-glucosamine + N-[6-phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine
N-[6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannosyl]-[uteroferrin]-L-asparagine + H2O
N-acetyl-D-glucosamine + N-[6-phospho-alpha-D-mannosyl]-[uteroferrin]-L-asparagine
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?
6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-D-mannose + H2O
N-acetyl-D-glucosamine + 6-phospho-D-mannose
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-
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?
6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-D-mannose + H2O
N-acetyl-D-glucosamine + 6-phospho-D-mannose
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-
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
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removes a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal acid hydrolases
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
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removes a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal hydrolases
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
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catalyzes a crucial step in lysosomal biogenesis, removes a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal hydrolases
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?
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O
N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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-
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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-
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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-
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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-
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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low activity
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?
methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
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-
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?
methyl 6-O-(N-acetyl-D-glucosaminyl)phospho-alpha D-mannose + H2O
N-acetyl-D-glucosamine + methyl 6-phospho-alpha-D-mannopyranoside
low activity
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?
methyl 6-O-(N-acetyl-D-glucosaminyl)phospho-alpha D-mannose + H2O
N-acetyl-D-glucosamine + methyl 6-phospho-alpha-D-mannopyranoside
low activity
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?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine + phosphate
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?
N-acetyl-alpha-D-glucosamine 1-phosphate
N-acetyl-D-glucosamine + phosphate
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?
N-[6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine + H2O
N-acetyl-D-glucosamine + N-[6-phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine
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?
N-[6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine + H2O
N-acetyl-D-glucosamine + N-[6-phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine
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the enzyme is also active on alpha-L-iduronidase that is recombinantly expressed in transgenic Arabidopsis thaliana seeds
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?
UDP-N-acetyl-alpha-D-glucosamine + H2O
N-acetyl-D-glucosamine + UDP
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?
additional information
?
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catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal enzyme oligosaccharides
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?
additional information
?
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removal of the GlcNAc moiety in the trans Golgi network to generate a phosphomonoester, second step of the post-translational modification of lysosomal enzymes with Man-6-P
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?
additional information
?
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D-mannose 6-phosphate phosphodiesters are converted to phosphomonoester
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?
additional information
?
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acts on a variety of compounds with N-acetyl-D-glucosamine alpha-linked to phosphate group, including biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes
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?
additional information
?
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acts on a variety of compounds with N-acetyl-D-glucosamine alpha-linked to phosphate group, including biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes
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?
