3.1.4.45: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, go to the full flat file.

Word Map on EC 3.1.4.45

Reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose
+
H2O
=
N-acetyl-D-glucosamine
+
glycoprotein phospho-D-mannose

Synonyms

alpha-N-acetylglucosaminylphosphodiesterase, phosphodiester glycosidase, lysosomal alpha-N-acetyl-glucosaminidase, alpha-N-acetyl-D-glucosamine-1-phosphodiester acetamidodeoxyglucohydrolase, phosphodiester alpha-GlcNAcase, N-acetylglucosamine-1-phosphodiester N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase, 2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase, UCE, mannose 6-phosphate-uncovering enzyme, NAGLU, mannose 6-phosphate uncovering enzyme, GH89, GlcNAc-1-phosphodiester-N-acetylglucosaminidase, uncovering enzyme, BACOVA_00430, GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.45 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

Reference

Reference on EC 3.1.4.45 - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kornfeld, R.; Bao, M.; Brewer, K.; Noll, C.; Canfield, W.
Molecular cloning and functional expression of two splice forms of human N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
J. Biol. Chem.
274
32778-32785
1999
Homo sapiens (Q9UK23), Homo sapiens
Manually annotated by BRENDA team
Kornfeld, R.; Bao, M.; Brewer, K.; Noll, C.; Canfield, W.
Purification and multimeric structure of bovine N-acetylglucosamine-phosphodiester alpha-N-acetylglucosaminidase
J. Biol. Chem.
273
23203-23210
1998
Bos taurus
Manually annotated by BRENDA team
Page, T.; Zhao, K.W.; Tao, l.; Miller, A.L.
Purification and characterization of human lymphoblast N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Glycobiology
6
619-626
1996
Homo sapiens
Manually annotated by BRENDA team
Lee, J.K.; Pierce, M.
Purification and characterization of human serum N-acetylgluosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Arch. Biochem. Biophys.
319
413-425
1995
Cricetulus griseus, Homo sapiens
Manually annotated by BRENDA team
Gheesling Mullis, K.; Huynh, M.; Kornfeld, R.H.
Purification and kinetic parameters of bovine liver N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
J. Biol. Chem.
269
1718-1726
1994
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Gheesling Mullis, K.; Kornfeld, R.H.
Characterization and immunolocalisation of bovine N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
J. Biol. Chem.
269
1727-1733
1994
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Ben-Yoseph, Y.; Potier, M.; Pack, B.A.; Mitchell, D.A.; Melancon, S.B.; Nadler, H.L.
Molecular size of N-acetylglucosaminylphosphotransferase and alpha-N-acetylglucosaminyl phosphodiesterase as determined in situ in Golgi membranes by radiation inactivation
Biochem. J.
235
883-886
1986
Homo sapiens
Manually annotated by BRENDA team
Varki, A.; Sherman.W.; Kornfeld, S.
Demonstration of the enzymatic mechanisms of alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase (formerly called alpha-N-acetylglucosaminylphosphodiesterase) and lysosomal alpha-N-acetylglucosaminidase
Arch. Biochem. Biophys.
222
145-149
1983
Rattus sp.
Manually annotated by BRENDA team
Pohlmann, R.; Waheed, A.; Hasilik, A.; von Figura, K.
Synthesis of phosphorylated recognition marker in lysosomal enzymes is located in the cis part of Golgi apparatus
J. Biol. Chem.
257
5323-5325
1982
Rattus sp.
Manually annotated by BRENDA team
Varki, A.; Kornfeld, S.
Purification and characterization of rat liver alpha-N-acetylglucosaminyl phosphodiesterase
J. Biol. Chem.
256
9937-9943
1981
Rattus sp.
Manually annotated by BRENDA team
Waheed, A.; Pohlmann, R.; Hasilik, A.; von Figura, K.
Subcellular location of two enzymes involved in the synthesis of phosphorylated recognition markers in lysosomal enzymes
J. Biol. Chem.
256
4150-4152
1981
Rattus sp.
Manually annotated by BRENDA team
Waheed, A.; Hasilik, A.; von Figura, K.
Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase
J. Biol. Chem.
256
5717-5721
1981
Homo sapiens
Manually annotated by BRENDA team
Varki, A.; Kornfeld, S.
Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing blocking alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes
J. Biol. Chem.
255
8398-8401
1980
Rattus sp.
Manually annotated by BRENDA team
Do, H.; Lee, W.S.; Ghosh, P.; Hollowell, T.; Canfield, W.; Kornfeld, S.
Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin
J. Biol. Chem.
277
29737-29744
2002
Homo sapiens
Manually annotated by BRENDA team
Lee, W.S.; Rohrer, J.; Kornfeld, R.; Kornfeld, S.
Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme
J. Biol. Chem.
277
3544-3551
2002
Homo sapiens
Manually annotated by BRENDA team
Rohrer, J.; Kornfeld, R.
Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network
Mol. Biol. Cell
12
1623-1631
2001
Homo sapiens
Manually annotated by BRENDA team
Wei, Y.; Yen, T.Y.; Cai, J.; Trent, J.O.; Pierce, W.M.; Young, W.W., Jr.
Structural features of the lysosomal hydrolase mannose 6-phosphate uncovering enzyme
Glycoconj. J.
22
13-19
2005
Homo sapiens
Manually annotated by BRENDA team
Nair, P.; Schaub, B.E.; Huang, K.; Chen, X.; Murphy, R.F.; Griffith, J.M.; Geuze, H.J.; Rohrer, J.
Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme
J. Cell Sci.
118
2949-2956
2005
Homo sapiens
Manually annotated by BRENDA team
Chavez, C.A.; Bohnsack, R.N.; Kudo, M.; Gotschall, R.R.; Canfield, W.M.; Dahms, N.M.
Domain 5 of the cation-independent mannose 6-phosphate receptor preferentially binds phosphodiesters (mannose 6-phosphate N-acetylglucosamine ester)
Biochemistry
46
12604-12617
2007
Homo sapiens
Manually annotated by BRENDA team
Ficko-Blean, E.; Stubbs, K.A.; Nemirovsky, O.; Vocadlo, D.J.; Boraston, A.B.
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
Proc. Natl. Acad. Sci. USA
105
6560-6565
2008
Clostridium perfringens
Manually annotated by BRENDA team
Lee, W.S.; Kang, C.; Drayna, D.; Kornfeld, S.
Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering
J. Biol. Chem.
286
39786-39793
2011
Homo sapiens
Manually annotated by BRENDA team
Das, D.; Lee, W.S.; Grant, J.C.; Chiu, H.J.; Farr, C.L.; Vance, J.; Klock, H.E.; Knuth, M.W.; Miller, M.D.; Elsliger, M.A.; Deacon, A.M.; Godzik, A.; Lesley, S.A.; Kornfeld, S.; Wilson, I.A.
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme
J. Biol. Chem.
288
16789-16799
2013
Homo sapiens, Bacteroides ovatus (A7LRK2), Bacteroides ovatus, Bacteroides ovatus ATCC 8483 (A7LRK2)
Manually annotated by BRENDA team
He, X.; Pierce, O.; Haselhorst, T.; von Itzstein, M.; Kolarich, D.; Packer, N.H.; Gloster, T.M.; Vocadlo, D.J.; Qian, Y.; Brooks, D.; Kermode, A.R.
Characterization and downstream mannose phosphorylation of human recombinant alpha-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds
Plant Biotechnol. J.
11
1034-1043
2013
Homo sapiens
Manually annotated by BRENDA team