3.1.4.45: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, go to the full flat file.

Reaction

Synonyms

2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, alpha-N-acetylglucosaminylphosphodiesterase, BACOVA_00430, GH89, GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase, GlcNAc-1-phosphodiester-N-acetylglucosaminidase, lysosomal alpha-N-acetyl-glucosaminidase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate uncovering enzyme, mannose 6-phosphate-uncovering enzyme, N-acetylglucosamine-1-phosphodiester N-acetylglucosaminidase, NAGLU, phosphodiester alpha-GlcNAcase, phosphodiester glycosidase, UCE, uncovering enzyme

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.4 Phosphoric-diester hydrolases

                3.1.4.45 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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Results	in table
1	Activating Compound
48	AA Sequence
1	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
241	Disease/ Diagnostics
10	General Information
1	General Stability
70	Inhibitors
2	Ki Value [mM]
16	KM Value [mM]
14	Localization
1	Metals/Ions
26	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
28	Organism
9	pH Optimum
4	pH Range
1	pH Stability
11	Posttranslational Modification
37	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
28	Reference
14	Source Tissue
3	Specific Activity [micromol/min/mg]
5	Storage Stability
42	Substrates and Products (Substrate)
8	Subunits
28	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.1.4.45 - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O

N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

3 entries

N-[6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine + H2O

N-acetyl-D-glucosamine + N-[6-phospho-alpha-D-mannosyl]-[alpha-L-iduronidase]-L-asparagine

Homo sapiens

-

-

730579

-

-

?

additional information

?

-

5 entries

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O

N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Homo sapiens

-

removes a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal acid hydrolases

652287

-

652287

?

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O

N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Homo sapiens

-

catalyzes a crucial step in lysosomal biogenesis, removes a covering N-acetylglucosamine from the mannose 6-phosphate recognition marker on lysosomal hydrolases

653178

-

653178

?

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O

N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

Rattus sp.

-

-

135498

-

-

?

additional information

?

-

Homo sapiens

-

catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal enzyme oligosaccharides

652305

-

652305

?

additional information

?

-

Homo sapiens

-

removal of the GlcNAc moiety in the trans Golgi network to generate a phosphomonoester, second step of the post-translational modification of lysosomal enzymes with Man-6-P

678230

-

-

?

additional information

?

-

Homo sapiens

-

D-mannose 6-phosphate phosphodiesters are converted to phosphomonoester

715644

-

-

?

additional information

?

-

Rattus sp.

-

acts on a variety of compounds with N-acetyl-D-glucosamine alpha-linked to phosphate group, including biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes

135496

-

-

?

additional information

?

-

Rattus sp.

-

acts on a variety of compounds with N-acetyl-D-glucosamine alpha-linked to phosphate group, including biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes

135498

-

-

?