3.1.4.45: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, go to the full flat file.

Word Map on EC 3.1.4.45

3.1.4.45

mucopolysaccharidosis

sanfilippo

heparan

mpsiiib

hgsnat

man-6-p

phosphomannosyl

n-acetylglucosamine-1-phosphotransferase

biotechnology

Reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose

Synonyms

2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester acetamidodeoxyglucohydrolase, alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, alpha-N-acetylglucosaminylphosphodiesterase, BACOVA_00430, GH89, GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase, GlcNAc-1-phosphodiester-N-acetylglucosaminidase, lysosomal alpha-N-acetyl-glucosaminidase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate uncovering enzyme, mannose 6-phosphate-uncovering enzyme, N-acetylglucosamine-1-phosphodiester N-acetylglucosaminidase, NAGLU, phosphodiester alpha-GlcNAcase, phosphodiester glycosidase, UCE, uncovering enzyme

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.45 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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Results	in table
1	Activating Compound
48	AA Sequence
1	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
241	Disease/ Diagnostics
10	General Information
1	General Stability
70	Inhibitors
2	Ki Value [mM]
16	KM Value [mM]
14	Localization
1	Metals/Ions
26	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
28	Organism
9	pH Optimum
4	pH Range
1	pH Stability
11	Posttranslational Modification
37	Protein Variants
11	Purification (Commentary)
1	Reaction
1	Reaction Type
28	Reference
14	Source Tissue
3	Specific Activity [micromol/min/mg]
5	Storage Stability
42	Substrates and Products (Substrate)
8	Subunits
28	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.1.4.45 - N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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2-acetamido-1,2-dideoxynojirimycin

Clostridium perfringens

competitive inhibitor

694897

6-acetamido-6-deoxycastanospermine

Clostridium perfringens

competitive inhibitor

694897

acetoamino-deoxycastanospermine

CdSO4

Cu2+

reduces activity by 30-40%

135491

CuSO4

Homo sapiens

135492

D-glucosamine 6-phosphate